PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15585641-8	2004	Cotreatment with the mTOR inhibitor rapamycin in vitro, or the ester of rapamycin, CCI-779 (Wyeth) in vivo, inhibited mTOR activity and restored sensitivity to tamoxifen, suggesting that Akt-induced tamoxifen resistance is mediated in part by signaling through the mTOR pathway.	Esters	63-68	mechanistic target of rapamycin kinase	Homo sapiens	118-122	
15585641-8	2004	Cotreatment with the mTOR inhibitor rapamycin in vitro, or the ester of rapamycin, CCI-779 (Wyeth) in vivo, inhibited mTOR activity and restored sensitivity to tamoxifen, suggesting that Akt-induced tamoxifen resistance is mediated in part by signaling through the mTOR pathway.	Esters	63-68	mechanistic target of rapamycin kinase	Homo sapiens	118-122	
15367412-9	2004	These findings indicate that inhibitors of mTOR, some of which are already in clinical development (CCI-779, an ester of rapamycin), have the potential to be effective in the treatment of breast cancer patients with PTEN-negative tumors and should be evaluated in this setting.	Esters	112-117	mechanistic target of rapamycin kinase	Homo sapiens	43-47	
30380865-0	2018	Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.	Esters	164-169	mechanistic target of rapamycin kinase	Homo sapiens	94-98	
24756806-1	2014	Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin (mTOR) and consequently blocks the translation of cell cycle regulatory proteins and prevents overexpression of angiogenic growth factors.	Esters	17-22	mechanistic target of rapamycin kinase	Homo sapiens	81-110	
24756806-1	2014	Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin (mTOR) and consequently blocks the translation of cell cycle regulatory proteins and prevents overexpression of angiogenic growth factors.	Esters	17-22	mechanistic target of rapamycin kinase	Homo sapiens	112-116	
20072839-1	2010	Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin and consequently blocks the translation of cell cycle regulatory proteins and prevents overexpression of angiogenic growth factors.	Esters	17-22	mechanistic target of rapamycin kinase	Homo sapiens	81-110	
18370442-1	2008	Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin and consequently blocks the translation of cell cycle regulatory proteins and prevents the over expression of angiogenic growth factors.	Esters	17-22	mechanistic target of rapamycin kinase	Homo sapiens	81-110