PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12118336-0	2002	Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression.	anthracene	44-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	91-97	
16120791-3	2005	TMS significantly inhibited CYP1-mediated 7-ethoxyresorufin O-deethylation activity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced MCF-7 cells or lung microsomes of Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene.	anthracene	225-235	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-32	
17089626-8	2006	Benzo/a/anthracene induction increases the mRNA expression of all inducible genes (CYP1A1, CYP1B1, AHRR) in the original embryonic cells, in Rausher virus-immortalized cells, and in transformed clone K2.	anthracene	8-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89	
12844379-2	2003	The soyabean isoflavone genistein was demonstrated earlier in our laboratory to be an effective inhibitor of dimethylbenz[a]anthracene (DMBA)-induced DNA damage in MCF-7 cells by curbing cytochrome P450 (CYP) 1 enzymes.	anthracene	124-134	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	187-210	
10496959-6	1999	Resveratrol was also effective in inhibiting CYP1A1 transcription induced by the aryl hydrocarbon dimethylbenz[a]anthracene in human mammary carcinoma MCF-7 cells.	anthracene	113-123	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51	
9622076-1	1998	CYP1B1 and CYP1A1 expression and metabolism of 7,12-dimethylbenz(a)anthracene (DMBA) have been characterized in early-passage human mammary epithelial cells (HMECs) isolated from reduction mammoplasty tissue of seven individual donors.	anthracene	67-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	11-17	
10357772-8	1999	Based on activities of recombinant enzyme and expression levels, differences in 7,2-dimethylbenz [a]anthracene (DMBA) metabolism between the cell lines were consistent with differences in CYP1A1 and CYP1B1 expression.	anthracene	100-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	188-194	
9918136-8	1998	In cultured epithelial cells, IQ-DNA adduct formation and CYP1A1, but not CYP1B1 expression were induced threefold by benz[a]anthracene treatment; IQ-DNA adduct formation was inhibited by alpha-naphthoflavone.	anthracene	125-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64	
19811694-6	2009	Resveratrol ranging from 1 to 5 microm could significantly suppress the expressions of cytochrome P450 (CYP) 1A1, CYP1B1 and UDP-glucuronosyltransferase (UGT) 1A1 induced by 7,12-dimethylbenz[a]anthracene (DMBA).	anthracene	194-204	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-112	
7663528-3	1995	The induced activity of CYP1A1 can be measured in vitro by the ethoxyresorufin-O-deethylase (EROD) activity in lymphocytes after induction by benz(a)anthracene (B(a)A).	anthracene	149-159	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-30	
4019509-2	1985	As is the case for cytochrome P-450c, arene 1,2-oxides have been identified as initial metabolites when naphthalene and anthracene are oxidized by cytochrome P-450b in a highly purified, reconstituted system.	anthracene	120-130	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-36	
4019509-10	1985	The data reported argue against a selective functional coupling mechanism between cytochrome P-450c and epoxide hydrolase in the metabolism of naphthalene and anthracene to the 1,2-dihydrodiols.	anthracene	159-169	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-99	
9662412-8	1998	CYP1A1 inhibition offers a possible explanation for the chemopreventative effect of genistein against, for example, dimethylbenz[a]anthracene genotoxicity reported in animals but the IC50 values negate the relevance of this specific chemopreventative action at the levels likely to be achieved from the human diet.	anthracene	131-141	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
26013842-3	2015	Topical application of the tumor initiator 7,12-dimethylbenz(a)anthracene (DMBA) enhances Pxr, Cyp1a1, Cyp1b1 and Cyp3a11, but not Ahr expression in the skin.	anthracene	63-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101	
7296539-3	1981	Kinetics for expression of benz[a]anthracene-(BA)-induced AHH activity, cyt c activity, and 3H-TdR incorporation were similar in both freshly cultured and cryopreserved cells.	anthracene	34-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-61	
25697376-0	2015	Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.	anthracene	39-49	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	141-159	
19362136-4	2009	In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7.	anthracene	195-205	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146	
19362136-4	2009	In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7.	anthracene	207-210	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146