PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22997752-5 2012 It is revealed that CYP1A1 Ile462Val polymorphism associates with pinguecula/pterygium, raising risk of their development almost in 3 times, unlike CYP 2E1 -1293G/C polymorphism. ile462val 27-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 21270613-1 2011 INTRODUCTION: This meta-analysis aims to examine whether the genotype status of Msp1, Ile462Val, and Thr461Asn polymorphisms in cytochrome P450 1A1 (CYP1A1) is associated with endometrial cancer risk. ile462val 86-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-147 20559649-7 2011 CONCLUSION: We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma. ile462val 53-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 23056546-2 2012 Increasing reports have focused on the association of CYP1A1 Ile462Val polymorphisms with susceptibility to acute leukemia and have generated controversial results. ile462val 61-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 23056546-12 2012 CONCLUSION: The results of the present study suggest that CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia. ile462val 65-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 22952673-0 2012 CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22952673-7 2012 This meta-analysis suggests that the Ile462Val polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility in Asian and Caucasian populations and there is an interaction with smoking status, but these associations vary in different histological types of lung caner. ile462val 37-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-70 21687948-5 2011 A similar occurrence has been observed with CYP1A1 Ile462Val and ercc1 C118T polymorphisms while patients who were carriers of MTHFR C677T polymorphism had a better response to methotrexate therapy, but an elevated risk of toxicity. ile462val 51-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 21270613-1 2011 INTRODUCTION: This meta-analysis aims to examine whether the genotype status of Msp1, Ile462Val, and Thr461Asn polymorphisms in cytochrome P450 1A1 (CYP1A1) is associated with endometrial cancer risk. ile462val 86-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 21246002-0 2011 CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 21246002-8 2011 CONCLUSION: CYP1A1 Ile462Val may be an increased risk factor for colorectal cancer. ile462val 19-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 18577398-0 2008 CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 20883830-2 2011 Previously we demonstrated that metabolic activation of estrogens by CYP1A1 is a genotype-dependent reaction with the CYP1A1.2 (Ile462Val) variant being the most efficient catalyst (Kisselev et al.). ile462val 128-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 69-75 20883830-2 2011 Previously we demonstrated that metabolic activation of estrogens by CYP1A1 is a genotype-dependent reaction with the CYP1A1.2 (Ile462Val) variant being the most efficient catalyst (Kisselev et al.). ile462val 128-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-124 20883830-7 2011 Whereas (wild-type) CYP1A1.1 was most inhibited by the whole crude extract, the variant CYP1A1.2 (Ile462Val) was significantly stronger inhibited by the constituents in its pure form: IC50 values for 2-hydroxylation was more than two times lower compared with the wild-type enzyme and the variant CYP1A1.4 (Thr461Asn). ile462val 98-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 20883830-7 2011 Whereas (wild-type) CYP1A1.1 was most inhibited by the whole crude extract, the variant CYP1A1.2 (Ile462Val) was significantly stronger inhibited by the constituents in its pure form: IC50 values for 2-hydroxylation was more than two times lower compared with the wild-type enzyme and the variant CYP1A1.4 (Thr461Asn). ile462val 98-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 20664892-4 2010 The MspI and Ile462Val polymorphisms in CYP1A1 gene were analysed using the Amplification Refractory Mutation System (ARMS) method. ile462val 13-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 20664892-6 2010 Genetic variations of CYP1A1 Ile462Val contribute to susceptibility to smoking-induced VTE in the Chinese populations. ile462val 29-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 18990008-8 2008 The occurrence of the combined variant genotypes of CYP1A1 Ile462Val and GSTM1 (37.8% vs. 8.3%) or CYP1A1 Ile462Val and TP53 Arg72Pro (24.3% vs. 0%) was significantly higher in the cases than in the controls. ile462val 59-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58 18990008-8 2008 The occurrence of the combined variant genotypes of CYP1A1 Ile462Val and GSTM1 (37.8% vs. 8.3%) or CYP1A1 Ile462Val and TP53 Arg72Pro (24.3% vs. 0%) was significantly higher in the cases than in the controls. ile462val 106-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 29595663-1 2018 OBJECTIVE: This meta-analysis aims to examine whether the MspI and Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) are associated with cervical cancer risk. ile462val 67-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-113 17063266-1 2007 We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk. ile462val 67-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 17531965-3 2007 RESULTS: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. ile462val 79-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-78 17531965-5 2007 CONCLUSION: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively. ile462val 64-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 16195240-0 2006 CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16195240-5 2006 Then we analysed gene-gene interactions, also incorporating our published data on the Ile462Val SNP in the phase I enzyme, cytochrome P450 CYP1A1. ile462val 86-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-145 11698341-2 2001 We have carried out a population based case-control study of the Thr461Asn and Ile462Val polymorphisms in CYP1A1 to clarify their importance in determining breast cancer susceptibility. ile462val 79-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-112 9610791-2 1998 We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based case-control study of lung cancer patients (247 cases and 185 controls) in Okinawa to ascertain the association of this variant with lung cancer. ile462val 15-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 16235998-5 2005 Among the subjects, the genotype frequency of CYP1A1 Ile462Val was 56.8% for Ile/Ile, 38.1% for Ile/Val and 5.1% for Val/Val. ile462val 53-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 15986113-0 2005 Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism. ile462val 62-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-61 15986113-1 2005 OBJECTIVE: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. ile462val 15-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-64 15986113-1 2005 OBJECTIVE: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. ile462val 15-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 71-77 15986113-7 2005 CONCLUSIONS: These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of developing non-small cell lung cancer, especially among women. ile462val 72-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 29595663-1 2018 OBJECTIVE: This meta-analysis aims to examine whether the MspI and Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) are associated with cervical cancer risk. ile462val 67-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 115-121 29595663-7 2018 CONCLUSION: This meta-analysis demonstrated that polymorphisms in MspI and Ile462Val of CYP1A1 were risk factors for developing cervical cancer. ile462val 75-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 27525656-3 2016 METHODS: PubMed, Embase, and CNKI databases were searched to identify the eligible studies focusing on the associations between CYP1A1 MspI and Ile462Val polymorphisms and susceptibility to endometriosis. ile462val 144-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 27525656-11 2016 CONCLUSIONS: This meta-analysis suggested that CYP1A1 Ile462Val polymorphism was associated with an increased risk of endometriosis, particularly in Asians. ile462val 54-63 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 47-53 29326607-0 2017 CYP1A1 Ile462Val Polymorphism Is Associated with Cervical Cancer Risk in Caucasians Not Asians: A Meta-Analysis. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29326607-1 2017 Objective: Previous studies have reported that Ile462Val polymorphism in the gene Cytochrome P450 1A1 (CYP1A1) is associated with the risk of cervical cancer, but inconsistent results have emerged. ile462val 47-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-101 29326607-1 2017 Objective: Previous studies have reported that Ile462Val polymorphism in the gene Cytochrome P450 1A1 (CYP1A1) is associated with the risk of cervical cancer, but inconsistent results have emerged. ile462val 47-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 103-109 29326607-3 2017 Methods: Studies involving the CYP1A1 Ile462Val polymorphism associated with cervical cancer risk were searched from the databases of PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI). ile462val 38-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 29326607-9 2017 Conclusion: The CYP1A1 Ile462Val polymorphism may enhance the susceptibility to cervical cancer in Caucasian females. ile462val 23-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 28425245-6 2017 The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39-26.04, P = 0.016). ile462val 151-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 27525656-7 2016 For CYP1A1 Ile462Val polymorphism, eight studies were available (878 cases and 1991 controls). ile462val 11-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 27525656-8 2016 In the overall analysis, CYP1A1 Ile462Val polymorphism had a statistically significant association with increased endometriosis risk in allele contrast and all genetic models except the model of Val/Ile vs. Ile/Ile. ile462val 32-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 26064254-3 2015 We did this meta-analysis to determine the association between CYP1A1 MspI and Ile462Val polymorphisms and UL risk. ile462val 79-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 27061602-2 2016 Many studies have investigated the association between the CYP1A1 MspI and Ile462Val polymorphisms and digestive tract cancer (DTC) risk in different groups of populations, but their results were inconsistent. ile462val 75-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 27333216-4 2016 Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. ile462val 0-9 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 27333216-8 2016 Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT/AG genotypes and TG haplotype could increase the UL risk. ile462val 20-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 26838244-2 2016 PURPOSE: The objective of this study was to assess the association between M2 (A2455G, Ile462Val) and M4 (C2453A, Thr461Asn) polymorphisms in CYP1A1 and breast cancer risk among Jordanian women and in subgroups stratified by menopausal status and smoking history. ile462val 87-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 142-148 27274286-0 2016 The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis. ile462val 30-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 23-29 27274286-1 2016 OBJECTIVE: The aim of this study was to address the association between the Ile462Val polymorphism in the gene encoding cytochrome P450 1A1 (CYP1A1) and the risk of head and neck cancer (HNC). ile462val 76-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 120-139 27274286-1 2016 OBJECTIVE: The aim of this study was to address the association between the Ile462Val polymorphism in the gene encoding cytochrome P450 1A1 (CYP1A1) and the risk of head and neck cancer (HNC). ile462val 76-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 141-147 27274286-6 2016 CONCLUSION: This cumulative meta-analysis suggests that the CYP1A1 Ile462Val polymorphism might contribute to the risk of HNC, particularly for pharyngeal cancer and laryngeal cancer. ile462val 67-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-66 26464823-0 2015 Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy. ile462val 45-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 26064254-7 2015 CYP1A1 Ile462Val polymorphism was significantly associated with UL risk (OR = 2.29, 95% CI 1.75-2.99, P < 0.00001). ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 26064254-11 2015 CONCLUSION: In summary, the results of the meta-analysis suggested that CYP1A1 Ile462Val polymorphism was significantly associated with UL risk. ile462val 79-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-78 24939416-0 2014 CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 25767599-0 2015 Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations. ile462val 27-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 25767599-2 2015 Many case-control studies have investigated the association between CYP1A1 Ile462Val polymorphism and OSCC susceptibility. ile462val 75-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 25343551-0 2014 CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 25343551-8 2014 CONCLUSIONS: The CYP1A1 Ile462Val variant was associated with a low risk of developing non-small cell lung cancer in a Chinese population. ile462val 24-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 17-23 24626963-0 2014 CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish population. ile462val 7-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 24939416-8 2014 Only CYP1A1 Ile462Val was statistically significant in CRC patients over 50 years old: OR 2.05 (1.29-3.28); p = 1.25E-02 and this association was more pronounced in the female group of CRC patients after the age of 50: OR 2.72 (1.43-5.14); p = 1.14E-02. ile462val 12-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 5-11 22948778-8 2012 In conclusion, this meta-analysis suggests that CYP1A1 Ile462Val polymorphism plays an important role in susceptibility to cervical cancer. ile462val 55-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 24320736-7 2014 CONCLUSION: The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci in CYP1A1 and Ala119Ser loci in CYP1B1 were risk factors for uterine leiomyoma development, and Leu432Val locus in CYB1B1 may be a protective factor. ile462val 85-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 116-122 23381648-7 2013 Subgroup analyses by ethnicity suggested that CYP1A1 Ile462Val polymorphism was associated with prostate cancer risk in Asians but not in Caucasians. ile462val 53-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 24964616-0 2014 [Association of CYP1A1 Ile462Val polymorphisms with susceptibility to small cell lung cancer]. ile462val 23-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 24964616-1 2014 OBJECTIVE: To investigate the association of Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) gene with small cell lung cancer susceptibility. ile462val 45-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-91 24964616-1 2014 OBJECTIVE: To investigate the association of Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) gene with small cell lung cancer susceptibility. ile462val 45-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 24964616-8 2014 CONCLUSION: CYP1A1 Ile462Val polymorphisms may contribute to the decreased susceptibility of small cell lung cancer. ile462val 19-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 24391993-0 2013 MspI and Ile462Val polymorphisms in CYP1A1 and overall cancer risk: a meta-analysis. ile462val 9-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 24391993-2 2013 To date, many studies have examined the association between CYP1A1 MspI and Ile462Val polymorphisms and cancer risk in various populations, but their results have been conflicting rather than consistent. ile462val 76-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-66 22359202-1 2012 A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published. ile462val 69-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 22426923-7 2012 Only one SNP, CYP1A1 rs1048943 A>G (Ile462Val), was significantly associated with PFS (P = 0.0003). ile462val 39-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 22426923-9 2012 CONCLUSION: CYP1A1 rs1048943 A>G (Ile462Val) polymorphism is a potential prognostic marker for survival outcome after docetaxel plus capecitabine chemotherapy in MBC patients. ile462val 37-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18