PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12433824-0	2002	Pharmacokinetics of midazolam and 1"-hydroxymidazolam in Chinese with different CYP3A5 genotypes.	1-hydroxymethylmidazolam	34-53	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	80-86	
15289787-8	2004	The 1"-hydroxymidazolam-to-midazolam area under the plasma concentration-time curve ratio was also significantly lower in the CYP3A5*3/*3 group (0.58 +/- 0.35 versus 1.09 +/- 0.37 for the homozygous wild-type group, P =.026).	1-hydroxymethylmidazolam	4-23	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	126-132	
15289787-10	2004	However, during cytochrome P450 (CYP) 3A inhibition by itraconazole, individuals carrying the CYP3A5*1 allele were found to be less susceptible to changes in systemic clearance and showed higher 1"-hydroxymidazolam-to-midazolam area under the plasma concentration-time curve ratios, probably resulting from the relatively CYP3A4-specific inhibition caused by itraconazole.	1-hydroxymethylmidazolam	195-214	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	94-100	
12433824-12	2002	The average AUC (0-8 h) of 1"-hydroxymidazolam was 3748 +/- 427 ng-min/ml in homozygous CYP3A5*3 subjects and 3920 +/- 402 ng-min/ml in heterozygous CYP3A5*1/*3 subjects.	1-hydroxymethylmidazolam	27-46	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	88-94	
12433824-12	2002	The average AUC (0-8 h) of 1"-hydroxymidazolam was 3748 +/- 427 ng-min/ml in homozygous CYP3A5*3 subjects and 3920 +/- 402 ng-min/ml in heterozygous CYP3A5*1/*3 subjects.	1-hydroxymethylmidazolam	27-46	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	149-155	
8185679-8	1994	Microsomal samples containing CYP3A5 in addition to CYP3A4 exhibited a significantly greater ratio of 1"-hydroxymidazolam to 4-hydroxymidazolam compared with samples containing only CYP3A4 or CYP3A7 (P < 0.001).	1-hydroxymethylmidazolam	102-121	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	30-36	
12124305-8	2002	The clearance for 1"-hydroxy midazolam formation at low substrate concentrations was similar for CYP3A4 and CYP3A5.	1-hydroxymethylmidazolam	18-38	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	108-114	
22415932-5	2012	The formation of 1"-hydroxymidazolam was studied in pooled human liver microsomes (HLM) and recombinant human CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) in the presence of efavirenz (0.5, 1, and 5 muM).	1-hydroxymethylmidazolam	17-36	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	121-127