PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9462845-2 1998 With an unequivocal (2S,3S) configuration this new trans-epoxysuccinyl peptide derivative was found to inhibit cathepsin B with an apparent second-order rate constant of 1,520,000 M(-1) s(-1) which represents so far the most potent inhibitor among E-64-derived compounds. Saccharin 21-26 cathepsin B Homo sapiens 111-122