PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26032855-5 2015 Based on the results of the pharmacological evaluation, we identified compound 8b with a saccharine moiety as the most potent and selective human acetylcholinesterase inhibitor (IC50 = 33 nM) and beta amyloid aggregation inhibitor. Saccharin 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Saccharin 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Saccharin 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215