PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24689792-3	2014	However, saccharin, a cyclic secondary sulfonamide, has unusually good inhibition of CA IX (Ki = 103 nM).	Saccharin	9-18	carbonic anhydrase 9	Homo sapiens	85-90	
31972093-0	2020	1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.	Saccharin	74-83	carbonic anhydrase 9	Homo sapiens	145-166	
31972093-0	2020	1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.	Saccharin	98-107	carbonic anhydrase 9	Homo sapiens	145-166	
29266943-3	2018	Previously, saccharin, a commonly used artificial sweetener, has been observed to selectively inhibit CA IX over other CA isoforms.	Saccharin	12-21	carbonic anhydrase 9	Homo sapiens	102-107	
30921738-2	2019	Simple cyclic sulfonamides, like saccharin (SAC), have shown up to a 60-fold selectivity towards CA IX over other ubiquitous CA isoforms, with greater selectivity obtained applying the "tail-approach" to derivatize SAC with a methylene triazole linker that connected to a "tail" beta glucoside.	Saccharin	33-42	carbonic anhydrase 9	Homo sapiens	97-102	
30034596-2	2018	Recent studies have demonstrated the selectivity of sucrose, saccharin, and acesulfame potassium for CA IX over other CA isoforms.	Saccharin	61-70	carbonic anhydrase 9	Homo sapiens	101-106	
18479784-2	2009	Various derivatizations of the ester moiety in the parent compound led to a small library of derivatives (2R,3R and 2S,3S) which displayed interesting inhibitory activities towards the human tumor-associated isoform CA IX.	Saccharin	116-121	carbonic anhydrase 9	Homo sapiens	216-221