PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17679938-11 2007 In Rac1-GTP pull-down assays, treatment of TM cells with 100 nM of JWH015 decreased the activity of Rac1 GTPase activity in a time-dependent manner. JHW 015 67-73 Rac family small GTPase 1 Homo sapiens 3-7 17679938-11 2007 In Rac1-GTP pull-down assays, treatment of TM cells with 100 nM of JWH015 decreased the activity of Rac1 GTPase activity in a time-dependent manner. JHW 015 67-73 Rac family small GTPase 1 Homo sapiens 100-104 17679938-12 2007 Pretreatment with 1 microM SR144528, but not with SR141716A, blocked the effect of JWH015 on Rac1 activity. JHW 015 83-89 Rac family small GTPase 1 Homo sapiens 93-97 17679938-15 2007 This study also shows that JWH015 modulates the activities of Rac1-GTPase and cofilin, which are important signaling molecules for the cytoskeletal and migratory properties of TM cells. JHW 015 27-33 Rac family small GTPase 1 Homo sapiens 62-73