PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31237151-7 2019 Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes. GPR39-C3 23-32 sirtuin 1 Homo sapiens 83-88 31237151-7 2019 Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes. GPR39-C3 142-151 sirtuin 1 Homo sapiens 110-115 31237151-7 2019 Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes. GPR39-C3 142-151 sirtuin 1 Homo sapiens 110-115