PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26389812-1 2015 By means of introgressing a loss-of-function mutation in the p22phox gene from the Matsumoto Eosinophilia Shinshu (MES) rat to stroke-prone spontaneously hypertensive rats (SHRSP), we constructed the SHRSP-based congenic strain lacking the P22PHOX expression (i.e., lacking NADPH oxidases [NOX] activities) (SHRSP.MES-Cyba(mes)/Izm; hereafter referred to as SP.MES). 2-(N-morpholino)ethanesulfonic acid 115-118 cytochrome b-245 alpha chain Rattus norvegicus 61-68 27824157-3 2016 The P22PHOX-depleted congenic SHRSP (called SP.MES) was constructed by introducing the mutated p22phox gene of Matsumoto Eosinophilic Shinshu rat. 2-(N-morpholino)ethanesulfonic acid 47-50 cytochrome b-245 alpha chain Rattus norvegicus 4-11 26389812-1 2015 By means of introgressing a loss-of-function mutation in the p22phox gene from the Matsumoto Eosinophilia Shinshu (MES) rat to stroke-prone spontaneously hypertensive rats (SHRSP), we constructed the SHRSP-based congenic strain lacking the P22PHOX expression (i.e., lacking NADPH oxidases [NOX] activities) (SHRSP.MES-Cyba(mes)/Izm; hereafter referred to as SP.MES). 2-(N-morpholino)ethanesulfonic acid 323-326 cytochrome b-245 alpha chain Rattus norvegicus 61-68 26389812-1 2015 By means of introgressing a loss-of-function mutation in the p22phox gene from the Matsumoto Eosinophilia Shinshu (MES) rat to stroke-prone spontaneously hypertensive rats (SHRSP), we constructed the SHRSP-based congenic strain lacking the P22PHOX expression (i.e., lacking NADPH oxidases [NOX] activities) (SHRSP.MES-Cyba(mes)/Izm; hereafter referred to as SP.MES). 2-(N-morpholino)ethanesulfonic acid 314-317 cytochrome b-245 alpha chain Rattus norvegicus 61-68 26389812-9 2015 Elimination of the P22PHOX expression induced complex distal MCA, which would suggest the presence of "loss of complexity" induced by enhanced oxidative stress in SHRSP; infarct size in SP.MES--when adjusted for distal MCA complexity--was significantly attenuated compared with that in PM0/SHRSP. 2-(N-morpholino)ethanesulfonic acid 189-192 cytochrome b-245 alpha chain Rattus norvegicus 19-26 21512270-0 2011 Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. 2-(N-morpholino)ethanesulfonic acid 55-58 cytochrome b-245 alpha chain Rattus norvegicus 70-74 21512270-0 2011 Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. 2-(N-morpholino)ethanesulfonic acid 66-69 cytochrome b-245 alpha chain Rattus norvegicus 70-74 21512270-0 2011 Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. 2-(N-morpholino)ethanesulfonic acid 75-78 cytochrome b-245 alpha chain Rattus norvegicus 70-74 21512270-2 2011 In contrast, BN.MES-Cyba(mes) congenic rats, in which the mutant Cyba(mes) gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. 2-(N-morpholino)ethanesulfonic acid 16-19 cytochrome b-245 alpha chain Rattus norvegicus 20-24 21512270-2 2011 In contrast, BN.MES-Cyba(mes) congenic rats, in which the mutant Cyba(mes) gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. 2-(N-morpholino)ethanesulfonic acid 25-28 cytochrome b-245 alpha chain Rattus norvegicus 65-69 21512270-2 2011 In contrast, BN.MES-Cyba(mes) congenic rats, in which the mutant Cyba(mes) gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. 2-(N-morpholino)ethanesulfonic acid 70-73 cytochrome b-245 alpha chain Rattus norvegicus 65-69 21512270-8 2011 These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba(mes) on these chromosomes, and form the basis for positional cloning studies of the genes. 2-(N-morpholino)ethanesulfonic acid 103-106 cytochrome b-245 alpha chain Rattus norvegicus 118-122 21512270-8 2011 These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba(mes) on these chromosomes, and form the basis for positional cloning studies of the genes. 2-(N-morpholino)ethanesulfonic acid 123-126 cytochrome b-245 alpha chain Rattus norvegicus 118-122 19406829-0 2009 Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). 2-(N-morpholino)ethanesulfonic acid 37-40 cytochrome b-245 alpha chain Rattus norvegicus 148-152 19406829-2 2009 Herein, we report that eosinophilia in MES rats is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba; also known as p22(phox)), which is an essential component of the superoxide-generating NADPH oxidase complex. 2-(N-morpholino)ethanesulfonic acid 39-42 cytochrome b-245 alpha chain Rattus norvegicus 144-148 19406829-9 2009 Eosinophilia of the MES rat was normalized by introduction of a normal Cyba transgene. 2-(N-morpholino)ethanesulfonic acid 20-23 cytochrome b-245 alpha chain Rattus norvegicus 71-75 20660993-0 2010 BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. 2-(N-morpholino)ethanesulfonic acid 3-6 cytochrome b-245 alpha chain Rattus norvegicus 7-11 20660993-0 2010 BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. 2-(N-morpholino)ethanesulfonic acid 12-15 cytochrome b-245 alpha chain Rattus norvegicus 7-11 20660993-3 2010 We bred and characterized a congenic strain, in which the mutant Cyba(mes) gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). 2-(N-morpholino)ethanesulfonic acid 134-137 cytochrome b-245 alpha chain Rattus norvegicus 65-69 20660993-3 2010 We bred and characterized a congenic strain, in which the mutant Cyba(mes) gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). 2-(N-morpholino)ethanesulfonic acid 134-137 cytochrome b-245 alpha chain Rattus norvegicus 138-142 20660993-3 2010 We bred and characterized a congenic strain, in which the mutant Cyba(mes) gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). 2-(N-morpholino)ethanesulfonic acid 70-73 cytochrome b-245 alpha chain Rattus norvegicus 65-69 20660993-3 2010 We bred and characterized a congenic strain, in which the mutant Cyba(mes) gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). 2-(N-morpholino)ethanesulfonic acid 70-73 cytochrome b-245 alpha chain Rattus norvegicus 138-142 20660993-8 2010 The newly established BN.MES-Cyba(mes) congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils. 2-(N-morpholino)ethanesulfonic acid 25-28 cytochrome b-245 alpha chain Rattus norvegicus 29-33 20660993-8 2010 The newly established BN.MES-Cyba(mes) congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils. 2-(N-morpholino)ethanesulfonic acid 34-37 cytochrome b-245 alpha chain Rattus norvegicus 29-33