PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18311061-6	2008	Here we found that intraperitoneal administrations of vanadium compounds, a stimulator of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal regulated kinase (ERK) pathways markedly enhances brain ischemia-induced neurogenesis.	Vanadium	54-62	AKT serine/threonine kinase 1	Homo sapiens	127-130	
19607982-6	2009	We found that intraperitoneal administration of vanadium compounds, a stimulator of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) pathways markedly enhances the brain ischemia-induced neurogenesis and promotes the migration of newborn cells.	Vanadium	48-56	AKT serine/threonine kinase 1	Homo sapiens	121-124	
19607982-7	2009	Thus, vanadium compounds are potential therapeutic agents to enhance the ischemia-induced neurogenesis through PI3K/Akt and ERK activation.	Vanadium	6-14	AKT serine/threonine kinase 1	Homo sapiens	116-119	
18781821-3	2008	OBJECTIVES: Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia/reperfusion-induced injury along with cardiac functional recovery.	Vanadium	12-20	AKT serine/threonine kinase 1	Homo sapiens	40-43	
18781821-5	2008	RESULTS/CONCLUSION: The ability of vanadium compounds to activate Akt signaling pathways are responsible for their ability to modulate cardiovascular functions and is probably beneficial as a cardioprotective drug in subjects undergoing reperfusion therapy following myocardial infarction.	Vanadium	35-43	AKT serine/threonine kinase 1	Homo sapiens	66-69	
18311061-7	2008	Thus, vanadium compounds are potential therapeutic agent to enhance ischemia-induced neurogenesis through PI3K/Akt and ERK activation.	Vanadium	6-14	AKT serine/threonine kinase 1	Homo sapiens	111-114	
27614430-3	2016	Moreover, the two vanadium compounds induced the activation of both PI3K/AKT and MAPK/ERK signaling pathways dose- and time-dependently, which could be counteracted with the antioxidant N-acetylcysteine.	Vanadium	18-26	AKT serine/threonine kinase 1	Homo sapiens	73-76	
17922021-6	2007	Two vanadium derivative inhibitors targeting PTEN significantly elevated the level of phosphorylated Akt (protein kinase B) and nearly doubled the wound healing rate in monolayer cultures of lung and airway epithelial cells.	Vanadium	4-12	AKT serine/threonine kinase 1	Homo sapiens	101-104	
14971662-4	2004	Exposure of mouse epidermal JB6 cells to vanadium led to phosphorylation of Akt and p70S6K in a time- and dose-dependent manner.	Vanadium	41-49	AKT serine/threonine kinase 1	Homo sapiens	76-79	
14971662-7	2004	Furthermore, vanadium-induced p70S6k phosphorylation at Thr389 and Thr421/Ser424 and Akt phosphorylation at Thr308 occurred through a PI-3K-dependent pathway because a PI-3K dominant negative mutant inhibited induction as compared with vector control cells.	Vanadium	13-21	AKT serine/threonine kinase 1	Homo sapiens	85-88	
27614430-9	2016	Therefore, vanadium compounds can be regarded as a novel type of anticancer drugs through the prolonged activation of MAPK/ERK pathway but retained AKT activity.	Vanadium	11-19	AKT serine/threonine kinase 1	Homo sapiens	148-151	
23576171-8	2013	This indicates that though both Akt and ERK pathways are activated by the vanadium compounds, only Akt activation contributes to the antilipolytic effect of the vanadium compounds, without the involvement of ERK activation.	Vanadium	161-169	AKT serine/threonine kinase 1	Homo sapiens	99-102	
23576171-7	2013	The antilipolytic effects of vanadium compounds were further evidenced by a decrease of the levels of phosphorylated HSL at Ser660 and phosphorylated perilipin, which were counteracted by inhibitors of PI3K or Akt but not by an MEK inhibitor.	Vanadium	29-37	AKT serine/threonine kinase 1	Homo sapiens	210-213	
23576171-8	2013	This indicates that though both Akt and ERK pathways are activated by the vanadium compounds, only Akt activation contributes to the antilipolytic effect of the vanadium compounds, without the involvement of ERK activation.	Vanadium	74-82	AKT serine/threonine kinase 1	Homo sapiens	32-35