PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23576171-7 2013 The antilipolytic effects of vanadium compounds were further evidenced by a decrease of the levels of phosphorylated HSL at Ser660 and phosphorylated perilipin, which were counteracted by inhibitors of PI3K or Akt but not by an MEK inhibitor. Vanadium 29-37 AKT serine/threonine kinase 1 Homo sapiens 210-213 27614430-3 2016 Moreover, the two vanadium compounds induced the activation of both PI3K/AKT and MAPK/ERK signaling pathways dose- and time-dependently, which could be counteracted with the antioxidant N-acetylcysteine. Vanadium 18-26 AKT serine/threonine kinase 1 Homo sapiens 73-76 27614430-9 2016 Therefore, vanadium compounds can be regarded as a novel type of anticancer drugs through the prolonged activation of MAPK/ERK pathway but retained AKT activity. Vanadium 11-19 AKT serine/threonine kinase 1 Homo sapiens 148-151 23576171-8 2013 This indicates that though both Akt and ERK pathways are activated by the vanadium compounds, only Akt activation contributes to the antilipolytic effect of the vanadium compounds, without the involvement of ERK activation. Vanadium 161-169 AKT serine/threonine kinase 1 Homo sapiens 99-102 23576171-8 2013 This indicates that though both Akt and ERK pathways are activated by the vanadium compounds, only Akt activation contributes to the antilipolytic effect of the vanadium compounds, without the involvement of ERK activation. Vanadium 74-82 AKT serine/threonine kinase 1 Homo sapiens 32-35 17922021-6 2007 Two vanadium derivative inhibitors targeting PTEN significantly elevated the level of phosphorylated Akt (protein kinase B) and nearly doubled the wound healing rate in monolayer cultures of lung and airway epithelial cells. Vanadium 4-12 AKT serine/threonine kinase 1 Homo sapiens 101-104 19607982-6 2009 We found that intraperitoneal administration of vanadium compounds, a stimulator of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) pathways markedly enhances the brain ischemia-induced neurogenesis and promotes the migration of newborn cells. Vanadium 48-56 AKT serine/threonine kinase 1 Homo sapiens 121-124 19607982-7 2009 Thus, vanadium compounds are potential therapeutic agents to enhance the ischemia-induced neurogenesis through PI3K/Akt and ERK activation. Vanadium 6-14 AKT serine/threonine kinase 1 Homo sapiens 116-119 18781821-3 2008 OBJECTIVES: Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia/reperfusion-induced injury along with cardiac functional recovery. Vanadium 12-20 AKT serine/threonine kinase 1 Homo sapiens 40-43 18781821-5 2008 RESULTS/CONCLUSION: The ability of vanadium compounds to activate Akt signaling pathways are responsible for their ability to modulate cardiovascular functions and is probably beneficial as a cardioprotective drug in subjects undergoing reperfusion therapy following myocardial infarction. Vanadium 35-43 AKT serine/threonine kinase 1 Homo sapiens 66-69 18311061-6 2008 Here we found that intraperitoneal administrations of vanadium compounds, a stimulator of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal regulated kinase (ERK) pathways markedly enhances brain ischemia-induced neurogenesis. Vanadium 54-62 AKT serine/threonine kinase 1 Homo sapiens 127-130 18311061-7 2008 Thus, vanadium compounds are potential therapeutic agent to enhance ischemia-induced neurogenesis through PI3K/Akt and ERK activation. Vanadium 6-14 AKT serine/threonine kinase 1 Homo sapiens 111-114 14971662-4 2004 Exposure of mouse epidermal JB6 cells to vanadium led to phosphorylation of Akt and p70S6K in a time- and dose-dependent manner. Vanadium 41-49 AKT serine/threonine kinase 1 Homo sapiens 76-79 14971662-7 2004 Furthermore, vanadium-induced p70S6k phosphorylation at Thr389 and Thr421/Ser424 and Akt phosphorylation at Thr308 occurred through a PI-3K-dependent pathway because a PI-3K dominant negative mutant inhibited induction as compared with vector control cells. Vanadium 13-21 AKT serine/threonine kinase 1 Homo sapiens 85-88