PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29855745-8 2018 TUNEL assay showed an increase in apoptotic index (0.14 +- 0.03; 0.15 +- 0.01) in vanadium-quercetin treated groups as compared to the carcinogen control (0.02 +- 0.01) along with upregulation of Bcl-2 and downregulation of Bax and p53. Vanadium 82-90 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 232-235 18539154-6 2008 The immunoexpression of tumor suppressor p53 and downregulation of antiapoptotic protein BCl-2 in subsequent immunofluorescence assay further provide strong evidence for the combinatorial inhibitory actions of vanadium and vitamin D(3) against DMH-induced rat colon carcinogenesis. Vanadium 210-218 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 41-44 15565650-0 2005 Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia. Vanadium 0-8 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 104-107 15565650-6 2005 An increased immunopositivity of p53 protein (1.03 +/- 0.23%; P < 0.02) was found in vanadium-treated rat liver with an elevated apoptotic-labeling index (AI; P < 0.001) as documented by TUNEL assay. Vanadium 88-96 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 33-36 15565650-8 2005 The results thus provide evidence for the first time in support of the potential role of vanadium on induction of p53 and apoptosis with concurrent suppression of MT and Ki-67 in order to have an understanding, in part, of the chemopreventive mechanism of this trace element in limiting neoplastic transformation in a defined model of experimental rat hepatocarcinogenesis. Vanadium 89-97 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 114-117 18155637-9 2008 A significant positive correlation between p53 immunoexpression and AI (P=0.0026, r=0.83, r(2)=0.69) links its association with vanadium-mediated apoptotic induction. Vanadium 128-136 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 43-46