PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15037661-5 2004 Here we extend the functional characterization of CtBP by demonstrating that amino acid substitutions at Gly189 in the conserved NAD+-binding fold both abrogate the ability of CtBP2 to homodimerize and are associated with a dramatic loss of co-repressor activity. ctbp 50-54 C-terminal binding protein 2 Homo sapiens 176-181 23264848-8 2012 An analysis of the Tiam1 promoter revealed binding sites for the CtBP-interacting Kruppel-like factor 8 (KLF8), and a Tiam1 promoter luciferase reporter was induced in the presence of both KLF8 and CtBP2, consistent with KLF8-dependent CtBP transactivation of Tiam1. ctbp 65-69 C-terminal binding protein 2 Homo sapiens 198-203