PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11222711-4 2001 Tcf4 is constitutively activated by mutations in the adenomatous polyposis coli and beta-catenin genes in virtually all colon tumors and is constitutively repressed by Groucho and CtBP in normal tissue. ctbp 180-184 transcription factor 4 Homo sapiens 0-4 16547505-0 2006 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. ctbp 93-97 transcription factor 4 Homo sapiens 25-30 16547505-0 2006 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. ctbp 93-97 transcription factor 4 Homo sapiens 25-30 16547505-4 2006 Of interest, we described a frequent TCF-4 frameshift mutation in mismatch-repair deficient colorectal cancers (MSI-H cancers) that leads to the selective loss of TCF-4 isoforms with CtBP binding abilities. ctbp 183-187 transcription factor 4 Homo sapiens 37-42 16547505-4 2006 Of interest, we described a frequent TCF-4 frameshift mutation in mismatch-repair deficient colorectal cancers (MSI-H cancers) that leads to the selective loss of TCF-4 isoforms with CtBP binding abilities. ctbp 183-187 transcription factor 4 Homo sapiens 163-168 16547505-5 2006 We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription. ctbp 64-68 transcription factor 4 Homo sapiens 74-79 16547505-5 2006 We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription. ctbp 100-104 transcription factor 4 Homo sapiens 74-79 16547505-5 2006 We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription. ctbp 100-104 transcription factor 4 Homo sapiens 74-79 16547505-7 2006 Taken together, our results strongly suggest that CtBP would play a role in regulating TCF-4 mediated transcription upon its binding with some TCF-4 isoforms encoded by alternatively spliced mRNA. ctbp 50-54 transcription factor 4 Homo sapiens 87-92 16547505-7 2006 Taken together, our results strongly suggest that CtBP would play a role in regulating TCF-4 mediated transcription upon its binding with some TCF-4 isoforms encoded by alternatively spliced mRNA. ctbp 50-54 transcription factor 4 Homo sapiens 143-148 16547505-0 2006 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. ctbp 93-97 transcription factor 4 Homo sapiens 0-5