PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28728106-3	2017	And the introduce of connecting amide bonds, enables the target molecules provide sufficient hydrogen bond donors and acceptors to interact with the catalytic site of BACE-1.	Amides	32-37	beta-secretase 1	Homo sapiens	167-173	
21621412-0	2011	Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer"s BACE1 inhibitors.	Amides	24-29	beta-secretase 1	Homo sapiens	111-116	
23837729-4	2013	To gain access to the S3 and S3 subpocket of the BACE1 active site, various linkers are described including nitrogen- and oxygen-based, aryl, and amide-based linkers.	Amides	146-151	beta-secretase 1	Homo sapiens	49-54	
23735744-0	2013	BACE1 inhibitors: a head group scan on a series of amides.	Amides	51-57	beta-secretase 1	Homo sapiens	0-5	
23735744-1	2013	A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based assay.	Amides	12-18	beta-secretase 1	Homo sapiens	80-85	
21319811-7	2011	Finally, EPR and electron spin echo modulation (ESEEM) applied to a suite of mutant and truncated alpha-syn constructs reveal a coordination sphere arising from the N-terminal amine, the Asp2 amide backbone and side chain carboxyl group, and the His50 imidazole.	Amides	192-197	beta-secretase 1	Homo sapiens	187-191	
21388807-1	2011	This Letter describes the de novo design of non-peptidic hydroxyethylamine (HEA) inhibitors of BACE-1 by elimination of P-gp contributing amide attachments.	Amides	138-143	beta-secretase 1	Homo sapiens	95-101	
19169270-9	2009	CONCLUSION: This study yielded several high activity compounds bearing fewer amino acids and amide bonds than previous compounds, providing insight into the further development of potent BACE-1 inhibitors for the treatment of Alzheimer"s disease.	Amides	93-98	beta-secretase 1	Homo sapiens	187-193	
16690314-0	2006	BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.	Amides	52-57	beta-secretase 1	Homo sapiens	0-6	
16690314-1	2006	A series of beta-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors containing a psi(CH2NH) reduced amide bond were synthesized.	Amides	116-121	beta-secretase 1	Homo sapiens	65-71	
29966870-3	2018	Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site.	Amides	142-147	beta-secretase 1	Homo sapiens	78-84	
30053756-5	2018	These newly-proposed tools were applied to determine the most probable protonation state of the aspartic dyad of BACE1, Asp93 and Asp289, in the presence of three types of transition state inhibitors namely: reduced amides, tertiary carbinamines and hydroxyethylamines.	Amides	216-222	beta-secretase 1	Homo sapiens	113-118