PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16140882-10	2005	PFE inhibited the IL-1beta-induced proteoglycan breakdown in cartilage explants in vitro.	Coconut Oil	0-3	interleukin 1 beta	Homo sapiens	18-26	
16140882-11	2005	At the cellular level, PFE (6.25-25 mg/L) inhibited the IL-1beta-induced expression of MMP-1, -3, and -13 protein in the medium (P < 0.05) and this was associated with the inhibition of mRNA expression.	Coconut Oil	23-26	interleukin 1 beta	Homo sapiens	56-64	
16140882-12	2005	IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay.	Coconut Oil	172-175	interleukin 1 beta	Homo sapiens	0-8	
16140882-12	2005	IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay.	Coconut Oil	197-200	interleukin 1 beta	Homo sapiens	0-8	
16140882-13	2005	PFE also inhibited the IL-1beta-induced phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor NF-kappaB in OA chondrocytes.	Coconut Oil	0-3	interleukin 1 beta	Homo sapiens	23-31