PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26064311-0 2015 Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and colorectal cancer (CRC) risk. pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 25182148-0 2015 The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-81 25182148-0 2015 The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 83-88 25182148-2 2015 Although the association of a common single nucleotide polymorphism (SNP), rs1801282 (Pro12Ala), in the peroxisome proliferator-activated receptor gamma (PPARG) gene with obesity has been reported in various populations, these data are not conclusive. pro12ala 86-94 peroxisome proliferator activated receptor gamma Homo sapiens 104-152 25182148-2 2015 Although the association of a common single nucleotide polymorphism (SNP), rs1801282 (Pro12Ala), in the peroxisome proliferator-activated receptor gamma (PPARG) gene with obesity has been reported in various populations, these data are not conclusive. pro12ala 86-94 peroxisome proliferator activated receptor gamma Homo sapiens 154-159 26355313-0 2015 PRO12ALA POLYMORPHISM ASSOCIATION OF PPAR-gamma GENE WITH BIOCHEMICAL PARAMETERS OF THE BLOOD IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 37-47 26355313-1 2015 The connection of Pro12Ala polymorphism of PPAR-gamma gene with blood biochemical parameters in patients with nonalcoholic fatty liver disease (NAFLD) and nonviral chronic hepatitis (CH) were analyzed. pro12ala 18-26 peroxisome proliferator activated receptor gamma Homo sapiens 43-53 25974167-0 2015 Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes. pro12ala 21-29 peroxisome proliferator activated receptor gamma Homo sapiens 14-20 25974167-14 2015 CONCLUSION: The association of MVPA with Matsuda-ISI was modified by PPARG2 Pro12Ala genotype with significant associations only observed in the 18% of the population who carried the Ala12 allele, whereas associations with sedentary time were unaffected. pro12ala 76-84 peroxisome proliferator activated receptor gamma Homo sapiens 69-75 26064311-0 2015 Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and colorectal cancer (CRC) risk. pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 26064311-2 2015 We conducted a meta-analysis to evaluate the association between PPARgamma Pro12Ala polymorphism and CRC risk. pro12ala 75-83 peroxisome proliferator activated receptor gamma Homo sapiens 65-74 26064311-10 2015 CONCLUSIONS: In conclusion, this meta-analysis suggested that PPARgamma Pro12Ala polymorphism was significant associated with CRC risk. pro12ala 72-80 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 25161890-2 2014 We previously demonstrated lower insulin secretion in minor allele carriers of PPARG Pro12Ala in high-NEFA environment, but the mode of action could not been revealed. pro12ala 85-93 peroxisome proliferator activated receptor gamma Homo sapiens 79-84 26361038-0 2015 Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis. pro12ala 12-20 peroxisome proliferator activated receptor gamma Homo sapiens 37-85 26361038-1 2015 BACKGROUND: The aim of this systematic review was to evaluate the relationship between obesity and peroxisome proliferator-activated receptor-gamma (PPARx03B3;) Pro12Ala polymorphism in healthy adults. pro12ala 161-169 peroxisome proliferator activated receptor gamma Homo sapiens 99-147 25161890-4 2014 Subjects with increased risk of diabetes who underwent oral glucose tolerance tests were genotyped for 7 tagging SNPs in FFAR1 and PPARG Pro12Ala. pro12ala 137-145 peroxisome proliferator activated receptor gamma Homo sapiens 131-136 24477323-0 2014 COMT Val158Met and PPARgamma Pro12Ala polymorphisms and susceptibility to Alzheimer"s disease: a meta-analysis. pro12ala 29-37 peroxisome proliferator activated receptor gamma Homo sapiens 19-28 24464185-0 2014 Associations between C1431T and Pro12Ala variants of PPARgamma gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population. pro12ala 32-40 peroxisome proliferator activated receptor gamma Homo sapiens 53-62 24464185-2 2014 The aim of this study was to investigate the association of C1431T and Pro12Ala polymorphisms of PPARgamma gene and their haplotypes and diplotypes with risk of metabolic syndrome (MetS) in an Iranian population. pro12ala 71-79 peroxisome proliferator activated receptor gamma Homo sapiens 97-106 24464185-12 2014 This study suggests that the PPARgamma C1431T polymorphism is related to an increased risk of MetS in an Iranian population and interacts with the Pro12Ala polymorphism, further increasing the risk of MetS. pro12ala 147-155 peroxisome proliferator activated receptor gamma Homo sapiens 29-38 23633103-0 2014 Association of Pro12Ala (rs1801282) variant of PPAR gamma with rheumatoid arthritis in a Pakistani population. pro12ala 15-23 peroxisome proliferator activated receptor gamma Homo sapiens 47-57 23633103-3 2014 In the present study, we aimed to investigate the association of PPARG (Pro12Ala; rs1801282) in clinically definite Pakistani Rheumatoid Arthritis (RA) patients and matching controls. pro12ala 72-80 peroxisome proliferator activated receptor gamma Homo sapiens 65-70 23633103-4 2014 The genotypes of the Pro12Ala variant in the PPARG were determined in a sample of 300 Pakistanis, including 150 RA cases and 150 controls. pro12ala 21-29 peroxisome proliferator activated receptor gamma Homo sapiens 45-50 23633103-10 2014 These observations suggest that Pro12Ala (rs1801282), a coding variant in the PPARG gene, is associated with Rheumatoid Arthritis in Pakistanis. pro12ala 32-40 peroxisome proliferator activated receptor gamma Homo sapiens 78-83 24477323-1 2014 The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met or the peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphisms are associated with susceptibility to Alzheimer"s disease (AD). pro12ala 163-171 peroxisome proliferator activated receptor gamma Homo sapiens 152-161 24477323-2 2014 We conducted a meta-analysis of the associations between the COMT Val158Met and the PPARgamma Pro12Ala polymorphisms and AD in subjects. pro12ala 94-102 peroxisome proliferator activated receptor gamma Homo sapiens 84-93 25371663-0 2014 The Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor Gamma Gene Modifies the Association of Physical Activity and Body Mass Changes in Polish Women. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-81 24649096-0 2014 Association of PPARG Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome. pro12ala 21-29 peroxisome proliferator activated receptor gamma Homo sapiens 15-20 24649096-3 2014 The aim of the present study was to establish a possible association of the PPARG Pro12Ala polymorphism with PCOS and its effect on family and personal history, as well as on the metabolic and endocrine parameters in PCOS patients. pro12ala 82-90 peroxisome proliferator activated receptor gamma Homo sapiens 76-81 25371663-2 2014 Studies on the functional importance of the PPARG Pro12Ala polymorphic variants indicated that the observed alleles may influence body mass measurements; however, obtained results were inconsistent. pro12ala 50-58 peroxisome proliferator activated receptor gamma Homo sapiens 44-49 24497707-0 2013 Distribution and genotype frequency of the C1431T and pro12ala polymorphisms of the peroxisome proliferator activator receptor gamma gene in an Iranian population. pro12ala 54-62 peroxisome proliferator activated receptor gamma Homo sapiens 84-132 23891824-4 2013 The objective of this study was to analyze the polymorphisms Leu162Val of PPARalpha and Pro12Ala of PPARgamma as genetic risk factors for the development and progression of NAFLD. pro12ala 88-96 peroxisome proliferator activated receptor gamma Homo sapiens 100-109 24040456-0 2013 The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome. pro12ala 19-27 peroxisome proliferator activated receptor gamma Homo sapiens 48-97 23866026-4 2013 Phthalate metabolites were determined by HPLC-MS. PPARgamma Pro12Ala (rs1801281) and PPARGC1B Ala203Pro (rs7732671) and Val279Ile (rs17572019) were genotyped. pro12ala 60-68 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 24040456-1 2013 BACKGROUND: The Pro12Ala polymorphism in the peroxisome Proliferator-activated receptor-gamma2 PPARgamma2) gene that account for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain elusive. pro12ala 16-24 peroxisome proliferator activated receptor gamma Homo sapiens 45-94 24040456-8 2013 However, in PCOS patients, the PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of serum fasting TG levels and fat-deposition in abdomen, respectively. pro12ala 42-50 peroxisome proliferator activated receptor gamma Homo sapiens 31-41 22653647-2 2012 Whether PPARg2 Pro12Ala polymorphism affects myocardial infarction is not clearly understood. pro12ala 15-23 peroxisome proliferator activated receptor gamma Homo sapiens 8-14 23799144-0 2013 Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 53-101 23799144-1 2013 BACKGROUND: The 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARgamma2 protein, resulting in low activation of the target genes. pro12ala 98-106 peroxisome proliferator activated receptor gamma Homo sapiens 36-84 23799144-1 2013 BACKGROUND: The 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARgamma2 protein, resulting in low activation of the target genes. pro12ala 98-106 peroxisome proliferator activated receptor gamma Homo sapiens 91-96 22528626-3 2013 Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction with lifestyle factors in an elderly population. pro12ala 37-45 peroxisome proliferator activated receptor gamma Homo sapiens 61-67 22729915-0 2012 Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: a meta-analysis. pro12ala 15-23 peroxisome proliferator activated receptor gamma Homo sapiens 40-88 22729915-1 2012 The association between Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma (PPAR) and polycystic ovary syndrome (PCOS) has been investigated in several studies, whereas results were often incompatible. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 49-97 22729915-1 2012 The association between Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma (PPAR) and polycystic ovary syndrome (PCOS) has been investigated in several studies, whereas results were often incompatible. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 99-103 22729915-2 2012 We conducted a meta-analysis to evaluate the association of Pro12Ala polymorphism in PPAR with PCOS susceptibility. pro12ala 60-68 peroxisome proliferator activated receptor gamma Homo sapiens 85-89 22515931-0 2012 Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population. pro12ala 25-33 peroxisome proliferator activated receptor gamma Homo sapiens 19-24 22653647-3 2012 We investigated a possible association of PPARg2 Pro12Ala polymorphism with obesity and myocardial infarction in Han Chinese in Hohhot, Inner Mongolia, China. pro12ala 49-57 peroxisome proliferator activated receptor gamma Homo sapiens 42-48 22653647-12 2012 We conclude that PPARg2 Pro12Ala polymorphisms are associated with increased risk for myocardial infarction in Han Chinese in Hohhot. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 17-23 21861709-0 2012 Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients. pro12ala 137-145 peroxisome proliferator activated receptor gamma Homo sapiens 88-136 22800638-0 2012 [Relationship between PPARgamma2 Pro12Ala polymorphism and type 2 diabetes mellitus in Chinese Han population: a Meta-analysis]. pro12ala 33-41 peroxisome proliferator activated receptor gamma Homo sapiens 22-32 22800638-1 2012 OBJECTIVE: To evaluate the relationship between peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) Pro12Ala polymorphism and type 2 diabetes mellitus (T2DM) in Chinese Han population. pro12ala 111-119 peroxisome proliferator activated receptor gamma Homo sapiens 48-97 22800638-1 2012 OBJECTIVE: To evaluate the relationship between peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) Pro12Ala polymorphism and type 2 diabetes mellitus (T2DM) in Chinese Han population. pro12ala 111-119 peroxisome proliferator activated receptor gamma Homo sapiens 99-109 22800638-12 2012 CONCLUSION: PPARgamma2 Pro12Ala polymorphism was not associated with type 2 diabetes mellitus in Chinese Han population. pro12ala 23-31 peroxisome proliferator activated receptor gamma Homo sapiens 12-22 21939732-0 2012 PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population. pro12ala 11-19 peroxisome proliferator activated receptor gamma Homo sapiens 0-5 23006958-0 2012 Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population. pro12ala 21-29 peroxisome proliferator activated receptor gamma Homo sapiens 14-20 23006958-11 2012 CONCLUSIONS: Although PPARG2 Pro12Ala polymorphism might attenuate associations between known risk factors and HbA1c level, it had a small effect on high-normal HbA1c, as compared with clinical risk factors, in the general population. pro12ala 29-37 peroxisome proliferator activated receptor gamma Homo sapiens 22-28 23300871-0 2012 The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARgamma2) is associated with increased risk of coronary artery disease: a meta-analysis. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-83 22619290-0 2012 Peroxisome proliferator-activated receptor gamma polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies. pro12ala 62-70 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 22619290-2 2012 The association between the peroxisome proliferator-activated receptor gamma Pro to Ala alteration at codon 12 (Pro12Ala) polymorphism and the risk of insulin resistance has been confirmed. pro12ala 112-120 peroxisome proliferator activated receptor gamma Homo sapiens 28-76 21861709-1 2012 AIM: The aim of the present study was to investigate the individual and combined effects of receptor for advanced glycation end products (RAGE) -374T/A, RAGE Gly82Ser, and peroxisome proliferator-activated receptor gamma (PPAR-gamma) Pro12Ala polymorphisms on the development of coronary artery disease (CAD). pro12ala 234-242 peroxisome proliferator activated receptor gamma Homo sapiens 172-220 20580778-0 2011 An age-dependent diet-modified effect of the PPARgamma Pro12Ala polymorphism in children. pro12ala 55-63 peroxisome proliferator activated receptor gamma Homo sapiens 45-54 22102511-0 2011 PPARgamma Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. pro12ala 10-18 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 22102511-1 2011 SCOPE: The goal of this study was to examine whether the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPARgamma) is associated with insulin resistance, obesity and weight loss and to analyze potential interactions between fat intake and PPARgamma polymorphism in a Spanish overweight/obese population. pro12ala 57-65 peroxisome proliferator activated receptor gamma Homo sapiens 82-130 22102511-1 2011 SCOPE: The goal of this study was to examine whether the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPARgamma) is associated with insulin resistance, obesity and weight loss and to analyze potential interactions between fat intake and PPARgamma polymorphism in a Spanish overweight/obese population. pro12ala 57-65 peroxisome proliferator activated receptor gamma Homo sapiens 132-141 22102511-1 2011 SCOPE: The goal of this study was to examine whether the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPARgamma) is associated with insulin resistance, obesity and weight loss and to analyze potential interactions between fat intake and PPARgamma polymorphism in a Spanish overweight/obese population. pro12ala 57-65 peroxisome proliferator activated receptor gamma Homo sapiens 267-276 22102511-6 2011 Furthermore, we detected an interaction between the PPARgamma Pro12Ala polymorphism and fat intake for total weight loss (p<0.001). pro12ala 62-70 peroxisome proliferator activated receptor gamma Homo sapiens 52-61 20045142-0 2010 Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus. pro12ala 78-86 peroxisome proliferator activated receptor gamma Homo sapiens 28-76 20045142-8 2010 Only the PPAR-gamma Pro12Ala polymorphism was found to be associated with the response of pioglitazone by multiple logistic regression analysis. pro12ala 20-28 peroxisome proliferator activated receptor gamma Homo sapiens 9-19 20406760-4 2010 The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes. pro12ala 123-131 peroxisome proliferator activated receptor gamma Homo sapiens 147-195 20406760-4 2010 The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes. pro12ala 123-131 peroxisome proliferator activated receptor gamma Homo sapiens 197-206 21206011-2 2010 The Pro12Ala polymorphism in the gene encoding PPARgamma (PPARgamma2 gene) influences the risk for type 2 diabetes. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 47-56 20045799-0 2009 The Pro12Ala polymorphism of the PPAR-gamma gene is not associated with the polycystic ovary syndrome. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-43 19733160-0 2009 Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. pro12ala 26-34 peroxisome proliferator activated receptor gamma Homo sapiens 51-101 19733160-1 2009 OBJECTIVES: This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population. pro12ala 71-79 peroxisome proliferator activated receptor gamma Homo sapiens 112-162 19733160-1 2009 OBJECTIVES: This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population. pro12ala 71-79 peroxisome proliferator activated receptor gamma Homo sapiens 164-175 20079163-7 2009 Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala. pro12ala 142-150 peroxisome proliferator activated receptor gamma Homo sapiens 136-141 20079163-7 2009 Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala. pro12ala 142-150 peroxisome proliferator activated receptor gamma Homo sapiens 401-406 20079163-7 2009 Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala. pro12ala 407-415 peroxisome proliferator activated receptor gamma Homo sapiens 136-141 19733160-10 2009 CONCLUSION: The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin. pro12ala 57-65 peroxisome proliferator activated receptor gamma Homo sapiens 86-97 20045799-3 2009 The aim of the study was to investigate the possible involvement of the Pro12Ala polymorphism of the PPAR-gamma gene in the pathogenesis of PCOS. pro12ala 72-80 peroxisome proliferator activated receptor gamma Homo sapiens 101-111 20112822-6 2009 All the participants were homozygous for Pro allele of Pro12Ala polymorph of PPAR-gamma gene. pro12ala 55-63 peroxisome proliferator activated receptor gamma Homo sapiens 77-87 18645733-2 2009 METHODS: Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 73-122 19199260-1 2009 OBJECTIVE: To investigate the association of the Pro12Ala variant in peroxisome proliferators-activated receptor gamma (PPAR gamma) gene with rheumatoid arthritis. pro12ala 49-57 peroxisome proliferator activated receptor gamma Homo sapiens 69-118 19199260-1 2009 OBJECTIVE: To investigate the association of the Pro12Ala variant in peroxisome proliferators-activated receptor gamma (PPAR gamma) gene with rheumatoid arthritis. pro12ala 49-57 peroxisome proliferator activated receptor gamma Homo sapiens 120-130 19199260-2 2009 METHODS: The genotypes of the Pro12Ala variant in the PPAR gamma gene were determined by polymerase chain reaction-restriction fragment length polymorphism in 421 unrelated subjects of the Han population in the Sichuan Province of China, including 207 subjects with rheumatoid arthritis and 214 subjects without the disease. pro12ala 30-38 peroxisome proliferator activated receptor gamma Homo sapiens 54-64 19199260-8 2009 The Pro12Ala polymorphism in the PPAR gamma gene in Sichuan Han population is similar to that in other populations in China, but different from that in European and American populations. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-43 18645733-0 2009 Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. pro12ala 26-34 peroxisome proliferator activated receptor gamma Homo sapiens 20-25 18645733-2 2009 METHODS: Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 124-129 18538667-0 2008 The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma2 gene is associated with plasma levels of soluble RAGE (Receptor for Advanced Glycation Endproducts) and the presence of peripheral arterial disease. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 29-78 17890503-5 2007 Among them, the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma, alone or in interaction with fat intake, significantly modulated waist circumference (p = 0.0005 for both effects). pro12ala 16-24 peroxisome proliferator activated receptor gamma Homo sapiens 41-89 18388889-1 2008 Conflicting results have been reported regarding the effect of the peroxisome proliferator-activated receptor-gamma-2 (PPARgamma2) Pro12Ala polymorphism, (singly or in combination with the silent C1431T polymorphism) on BMI. pro12ala 131-139 peroxisome proliferator activated receptor gamma Homo sapiens 67-117 18388889-1 2008 Conflicting results have been reported regarding the effect of the peroxisome proliferator-activated receptor-gamma-2 (PPARgamma2) Pro12Ala polymorphism, (singly or in combination with the silent C1431T polymorphism) on BMI. pro12ala 131-139 peroxisome proliferator activated receptor gamma Homo sapiens 119-129 18160840-0 2007 The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women. pro12ala 19-27 peroxisome proliferator activated receptor gamma Homo sapiens 44-92 18160840-5 2007 DNAs were extracted from the samples and the genotyping of the Pro12Ala polymorphism (rs1801282) in the PPAR-gamma gene was performed via an allelic discrimination assay using a TaqMan probe. pro12ala 63-71 peroxisome proliferator activated receptor gamma Homo sapiens 104-114 18160840-6 2007 In addition, we examined the haplotype analysis between two polymorphisms of PPAR-gamma gene, Pro12Ala in exon B and C161T in exon 6 (rs3856806). pro12ala 94-102 peroxisome proliferator activated receptor gamma Homo sapiens 77-87 17653445-6 2007 The gene variant PPARG Pro12Ala was studied by a PCR-based method and the association between this genetic polymorphism and obesity-related phenotypes was evaluated by analysis of covariance. pro12ala 23-31 peroxisome proliferator activated receptor gamma Homo sapiens 17-22 17653445-9 2007 In the male sample, an association between the PPARG Pro12Ala variant and body mass index was detected, with male carriers of the Ala variant presenting a higher mean body mass index than wild-type homozygotes (28.3 vs 26.2 kg/m2, P = 0.037). pro12ala 53-61 peroxisome proliferator activated receptor gamma Homo sapiens 47-52 17624182-11 2007 CONCLUSIONS: Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding. pro12ala 45-53 peroxisome proliferator activated receptor gamma Homo sapiens 34-44 17415545-0 2007 The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 29-35 17270153-0 2007 The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer"s disease in octogenarians. pro12ala 67-75 peroxisome proliferator activated receptor gamma Homo sapiens 4-52 17270153-2 2007 Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is involved in such processes, so we thought it interesting to study the Pro12Ala polymorphism in exon 2 of the gene in a sample of late-onset AD patients. pro12ala 135-143 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 17270153-2 2007 Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is involved in such processes, so we thought it interesting to study the Pro12Ala polymorphism in exon 2 of the gene in a sample of late-onset AD patients. pro12ala 135-143 peroxisome proliferator activated receptor gamma Homo sapiens 50-60 17493550-0 2007 Peroxisome proliferator-activated receptor gamma polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes. pro12ala 62-70 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 17493550-1 2007 AIM: One putative determinant of diabetic nephropathy is the Pro12Ala (P12A) polymorphism in the gene encoding peroxisome proliferator-activated receptor gamma (PPARgamma). pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 111-159 17493550-1 2007 AIM: One putative determinant of diabetic nephropathy is the Pro12Ala (P12A) polymorphism in the gene encoding peroxisome proliferator-activated receptor gamma (PPARgamma). pro12ala 61-69 peroxisome proliferator activated receptor gamma Homo sapiens 161-170 17624182-9 2007 For PPARgamma2 Pro12Ala most traits of twin pairs sharing 2 alleles of IBS had greater correlations and statistic significance in body mass index (BMI), WHR, percent of body fat (PBF) and GLU, but there were low correlations of either insulin or HOMA-IR of twin pairs sharing 1 or 2 alleles of IBS. pro12ala 15-23 peroxisome proliferator activated receptor gamma Homo sapiens 4-14 17292728-1 2007 The objective of the study was to test for an association between type 2 diabetes mellitus (T2DM) and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPAR-gamma) in families from Colorado. pro12ala 106-114 peroxisome proliferator activated receptor gamma Homo sapiens 135-183 17292728-1 2007 The objective of the study was to test for an association between type 2 diabetes mellitus (T2DM) and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPAR-gamma) in families from Colorado. pro12ala 106-114 peroxisome proliferator activated receptor gamma Homo sapiens 190-200 17292728-3 2007 We studied 216 Hispanic pedigrees (1850 nuclear families) and 236 non-Hispanic white (NHW) pedigrees (1240 families) from the San Luis Valley and Denver, CO. We genotyped the Pro12Ala polymorphism of the PPAR-gamma gene. pro12ala 175-183 peroxisome proliferator activated receptor gamma Homo sapiens 204-214 17187763-5 2007 Reporter gene assays in HepG2 cells with wildtype and mutant proteins of both PGC1alpha and PPARgamma2 (Pro12Ala, rs1801282) using the acyl-CoA-binding protein (ACBP) promoter showed no difference in coactivator activity. pro12ala 104-112 peroxisome proliferator activated receptor gamma Homo sapiens 92-102 17187763-6 2007 This is the first study implicating that the Gly482Ser and Thr612Met polymorphisms in PGC-1alpha and Pro12Ala polymorphism in PPARgamma2 do not affect the functional integrity of these proteins. pro12ala 101-109 peroxisome proliferator activated receptor gamma Homo sapiens 126-136 17985660-0 2007 Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. pro12ala 22-30 peroxisome proliferator activated receptor gamma Homo sapiens 15-21 17985660-1 2007 Previous studies have sought to associate the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 (PPARG2) gene with type 2 diabetes, insulin resistance, and obesity, with controversial results. pro12ala 46-54 peroxisome proliferator activated receptor gamma Homo sapiens 70-119 17985660-1 2007 Previous studies have sought to associate the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 (PPARG2) gene with type 2 diabetes, insulin resistance, and obesity, with controversial results. pro12ala 46-54 peroxisome proliferator activated receptor gamma Homo sapiens 121-127 17348446-6 2007 A marginally significant increased risk of breast cancer was observed among women homozygous for the Ala allele of PPARgamma Pro12Ala. pro12ala 125-133 peroxisome proliferator activated receptor gamma Homo sapiens 115-124 18159845-0 2007 [The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma and immunological processes in patients with type 2 diabetes and insulin resistance]. pro12ala 5-13 peroxisome proliferator activated receptor gamma Homo sapiens 34-82 17359638-0 2007 Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism is associated with the susceptibility to ischemic stroke in Taeeumin classified by Sasang medicine. pro12ala 49-57 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 17359638-4 2007 The constitutional type of each patient and control subject (n = 129) was classified and genotyped for PPAR-gamma polymorphism Pro12Ala by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) methods. pro12ala 127-135 peroxisome proliferator activated receptor gamma Homo sapiens 103-113 16965392-0 2006 Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. pro12ala 39-47 peroxisome proliferator activated receptor gamma Homo sapiens 79-88 16625233-0 2006 Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 48-97 16916989-0 2006 Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 33-38 17322577-4 2006 Therefore, we investigated the effect of the Pro12Ala polymorphism of PPARgamma2 on SHBG levels in 202 young Finnish men. pro12ala 45-53 peroxisome proliferator activated receptor gamma Homo sapiens 70-80 17322577-7 2006 SHBG levels tended to be higher among the subjects with the Ala12Ala genotype compared to subjects with the Pro12Pro or Pro12Ala genotypes of the PPARgamma gene (27.7 vs 21.7 and 22.7 nmol/L). pro12ala 120-128 peroxisome proliferator activated receptor gamma Homo sapiens 146-155 16804087-0 2006 Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. pro12ala 106-114 peroxisome proliferator activated receptor gamma Homo sapiens 131-137 16644635-1 2006 OBJECTIVE: To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians. pro12ala 92-100 peroxisome proliferator activated receptor gamma Homo sapiens 36-91 16777151-6 2006 Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat. pro12ala 54-62 peroxisome proliferator activated receptor gamma Homo sapiens 195-200 16777151-7 2006 Moreover, our evidence suggests that PPARG C-681G and pro12ala polymorphisms display opposing effects in terms of growth phenotype, with pro12Ala associated with deficient energy utilisation, leading to reduced growth and the G-681 variant associated with accelerated growth compared with wildtypes. pro12ala 137-145 peroxisome proliferator activated receptor gamma Homo sapiens 37-42 16108843-2 2005 METHODS: We genotyped two common PPARgamma polymorphisms (Pro12Ala and 161C > T) and examined their association with the clinical phenotypes found in 684 patients with Type 2 diabetes mellitus and 291 non-diabetic control subjects. pro12ala 58-66 peroxisome proliferator activated receptor gamma Homo sapiens 33-42 16763406-2 2006 In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer. pro12ala 57-65 peroxisome proliferator activated receptor gamma Homo sapiens 82-92 16763406-9 2006 CONCLUSIONS: Our results suggest a novel gene-environment interaction between the PPAR-gamma Pro12Ala polymorphism and body mass in prostate cancer. pro12ala 93-101 peroxisome proliferator activated receptor gamma Homo sapiens 82-92 16420563-3 2006 RESULTS: Of the 92 polymorphisms tested, three that we previously reported on were associated with risk of MI, [pro12ala in the peroxisome proliferator activated-receptor gamma gene (odds ratio, OR = 0.75, P = 0.02); thr164ile in the beta-2 adrenergic receptor gene (OR = 0.14, P = 0.007); and ala23thr polymorphism in the eotaxin gene (OR = 1.87, P = 0.01)]. pro12ala 112-120 peroxisome proliferator activated receptor gamma Homo sapiens 128-176 16789503-0 2005 [Influence of polymorphism pro12Ala of PPARgamma gene on endothelium destruction in patients with diabetes mellitus t. 2]. pro12ala 27-35 peroxisome proliferator activated receptor gamma Homo sapiens 39-48 16050954-0 2005 Association between Pro12Ala polymorphism of the PPAR-gamma2 gene and insulin sensitivity in Brazilian patients with type-2 diabetes mellitus. pro12ala 20-28 peroxisome proliferator activated receptor gamma Homo sapiens 49-60 16050954-2 2005 The purpose of this study is to investigate the association of Pro12Ala polymorphism at the PPAR-gamma2 gene in Brazilian patients with type-2 diabetes mellitus (T2Dm) and controls (CG). pro12ala 63-71 peroxisome proliferator activated receptor gamma Homo sapiens 92-103 12161548-0 2002 Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. pro12ala 24-32 peroxisome proliferator activated receptor gamma Homo sapiens 53-63 15715885-5 2005 Mutation analyses of selected "candidate" susceptibility genes in various populations have also identified the widespread Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma and the common Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11). pro12ala 122-130 peroxisome proliferator activated receptor gamma Homo sapiens 146-194 12354130-0 2002 Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals. pro12ala 50-58 peroxisome proliferator activated receptor gamma Homo sapiens 79-135 12354130-1 2002 BACKGROUND: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma gene has been associated in some, but not all, studies with lower body mass index (BMI) and improved insulin sensitivity; how an altered transcriptional activity of PPARgamma2 could influence insulin sensitivity is currently unclear. pro12ala 16-24 peroxisome proliferator activated receptor gamma Homo sapiens 45-100 15860437-2 2005 In this study we evaluated the association between the Pro12Ala (P12A) PPARgamma polymorphism and body mass index (BMI), waist-to-hip ratio (WHR), physical activity level, and energy intake and risk of colorectal cancer using data from a population-based, case-control study of colon cancer (1,577 cases and 1,971 controls) and rectal cancer (794 cases and 1,001 controls). pro12ala 55-63 peroxisome proliferator activated receptor gamma Homo sapiens 71-80 15562398-0 2004 Pro12Ala substitution in peroxisome proliferator-activated receptor gamma 2 is associated with low adiponectin concentrations in young Japanese men. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 25-75 12161548-1 2002 The Pro12Ala polymorphism of PPAR-gamma 2 has been shown to influence insulin sensitivity and the risk of type 2 diabetes in various ethnic populations. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 29-39 11862322-1 2002 The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene is associated with a reduced risk of type 2 diabetes. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-89 11928067-0 2002 Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 29-78 12218380-0 2002 Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 29-77 11692187-0 2001 Mutations of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene in a Japanese population : the Pro12Ala mutation in PPAR gamma 2 is associated with lower concentrations of serum total and non-HDL cholesterol. pro12ala 115-123 peroxisome proliferator activated receptor gamma Homo sapiens 17-65 11692187-0 2001 Mutations of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene in a Japanese population : the Pro12Ala mutation in PPAR gamma 2 is associated with lower concentrations of serum total and non-HDL cholesterol. pro12ala 115-123 peroxisome proliferator activated receptor gamma Homo sapiens 67-77 11692187-0 2001 Mutations of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene in a Japanese population : the Pro12Ala mutation in PPAR gamma 2 is associated with lower concentrations of serum total and non-HDL cholesterol. pro12ala 115-123 peroxisome proliferator activated receptor gamma Homo sapiens 136-146 11402923-0 2001 [Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity]. pro12ala 17-25 peroxisome proliferator activated receptor gamma Homo sapiens 29-79 11402923-0 2001 [Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity]. pro12ala 17-25 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 10973253-0 2000 The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. pro12ala 21-29 peroxisome proliferator activated receptor gamma Homo sapiens 11-20 11289055-0 2001 Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity. pro12ala 0-8 peroxisome proliferator activated receptor gamma Homo sapiens 29-78 11289055-1 2001 The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma2 is associated with reduced transcriptional activity in vitro and increased insulin sensitivity in humans in vivo. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-89 10973253-4 2000 We were able to confirm only one association, that of the common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma(PPARgamma) with type 2 diabetes. pro12ala 65-73 peroxisome proliferator activated receptor gamma Homo sapiens 90-138 10973253-4 2000 We were able to confirm only one association, that of the common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma(PPARgamma) with type 2 diabetes. pro12ala 65-73 peroxisome proliferator activated receptor gamma Homo sapiens 139-148 9792554-0 1998 Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. pro12ala 19-27 peroxisome proliferator activated receptor gamma Homo sapiens 43-92 10440134-0 1999 Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men. pro12ala 20-28 peroxisome proliferator activated receptor gamma Homo sapiens 96-107 10440134-1 1999 AIMS/HYPOTHESIS: The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) whether the relation of a Pro12Ala polymorphism in PPAR-gamma2 with BMI and long-term weight regulation differ between lean and obese subjects within the same cohort. pro12ala 281-289 peroxisome proliferator activated receptor gamma Homo sapiens 116-165 10440134-1 1999 AIMS/HYPOTHESIS: The objectives of the present investigation were to examine: 1) whether a Pro115Gln variant in the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with juvenile-onset obesity among Danish Caucasianmen and 2) whether the relation of a Pro12Ala polymorphism in PPAR-gamma2 with BMI and long-term weight regulation differ between lean and obese subjects within the same cohort. pro12ala 281-289 peroxisome proliferator activated receptor gamma Homo sapiens 167-178 11001532-0 2000 The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II. pro12ala 4-12 peroxisome proliferator activated receptor gamma Homo sapiens 33-82 11001532-1 2000 This study investigated whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene is associated with glucose and lipid metabolism in young healthy subjects participating in the European Atherosclerosis Research Study II. pro12ala 36-44 peroxisome proliferator activated receptor gamma Homo sapiens 65-114 11001532-1 2000 This study investigated whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene is associated with glucose and lipid metabolism in young healthy subjects participating in the European Atherosclerosis Research Study II. pro12ala 36-44 peroxisome proliferator activated receptor gamma Homo sapiens 116-126 34459761-1 2021 OBJECTIVE: The aim: To study the association between the effectiveness of treatment with pioglitazone non-alcoholic fatty liver disease (NAFLD) in patients with obesity and PPARG rs1801282 (Pro12Ala)-polymorphism in Ukrainians. pro12ala 190-198 peroxisome proliferator activated receptor gamma Homo sapiens 173-178 35560467-0 2022 A Personalized Diet Approach Study: Interaction between PPAR-gamma Pro12Ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients. pro12ala 67-75 peroxisome proliferator activated receptor gamma Homo sapiens 56-66 35560467-1 2022 BACKGROUND: The objectives were to investigate the effect of the interaction between peroxisome proliferator-activated receptor gamma (PPAR-gamma) Pro12Ala polymorphisms and dietary insulin load and insulin index (DIL and DII) on Cardio-metabolic Markers among diabetic patients. pro12ala 147-155 peroxisome proliferator activated receptor gamma Homo sapiens 85-133 35560467-4 2022 PPAR-gamma Pro12Ala was genotyped by the PCR-RFLP method. pro12ala 11-19 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 35560467-10 2022 CONCLUSION: We revealed PPAR-gamma Pro12Ala polymorphism was able to intensify the effect of DIL and DII on CVD risk factors; risk-allele carriers who consumed a diet with high DIL and DII score have more likely to be obese and have higher inflammatory markers. pro12ala 35-43 peroxisome proliferator activated receptor gamma Homo sapiens 24-34 35265101-3 2022 Previous studies have examined one important exon polymorphism, Pro12Ala, in PPARG with respect to mortality of CKD patients, but the results were inconsistent and current evidence is insufficient to support a strong conclusion. pro12ala 64-72 peroxisome proliferator activated receptor gamma Homo sapiens 77-82 35265101-11 2022 Conclusion: We found that PPARG Pro12Ala gene polymorphism was not related to mortality in CKD Asians patients, and validated our conclusion using TSA after adding our sample. pro12ala 32-40 peroxisome proliferator activated receptor gamma Homo sapiens 26-31 29970681-1 2018 Aims: Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARgamma) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC). pro12ala 118-126 peroxisome proliferator activated receptor gamma Homo sapiens 56-105 29970681-1 2018 Aims: Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARgamma) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC). pro12ala 118-126 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 29970681-5 2018 Results: A significantly decreased CRC risk was found for PPARgamma Pro12Ala polymorphism (OR = 0.88, 95% CI 0.83-0.94, P < 0.0001). pro12ala 68-76 peroxisome proliferator activated receptor gamma Homo sapiens 58-67 29970681-10 2018 Conclusions: PPARgamma Pro12Ala and His477His polymorphisms might be associated with susceptibility of CRC. pro12ala 23-31 peroxisome proliferator activated receptor gamma Homo sapiens 13-22 29610599-1 2018 BACKGROUND: Pro12Ala (rs1801282) is a common polymorphism of the human PPAR-gamma gene. pro12ala 12-20 peroxisome proliferator activated receptor gamma Homo sapiens 71-81 28698741-1 2017 AIM: To investigate the association of peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women. pro12ala 96-104 peroxisome proliferator activated receptor gamma Homo sapiens 39-87 28698741-1 2017 AIM: To investigate the association of peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women. pro12ala 96-104 peroxisome proliferator activated receptor gamma Homo sapiens 89-94 28698741-2 2017 METHODS: The study used PCR to identify the presence of the PPARG Pro12Ala polymorphism in 100 PCOS women and 120 age-matched healthy women. pro12ala 66-74 peroxisome proliferator activated receptor gamma Homo sapiens 60-65 28698741-4 2017 RESULTS: Significant difference in the genotypes distributions of PPARG Pro12Ala polymorphism was observed among PCOS women and controls (p = 0.03). pro12ala 72-80 peroxisome proliferator activated receptor gamma Homo sapiens 66-71 28698741-7 2017 CONCLUSION: The PPARG Pro12Ala polymorphism might contribute to the risk of PCOS and abnormal metabolic parameters and could be considered as a biomarker for early diagnosis and clinic prediction of metabolic complications. pro12ala 22-30 peroxisome proliferator activated receptor gamma Homo sapiens 16-21 29402778-0 2017 Interaction of Vitamin E Intake and Pro12Ala Polymorphism of PPARG with Adiponectin Levels. pro12ala 36-44 peroxisome proliferator activated receptor gamma Homo sapiens 61-66 29402778-2 2017 The aim of this study was to analyze the adiponectin levels in subjects with the Pro12Ala polymorphism of PPARG according to vitamin E intake. pro12ala 81-89 peroxisome proliferator activated receptor gamma Homo sapiens 106-111