PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8983343-8 1996 Therefore, the possible role of the copolymer in inhibition of non-P-gp drug resistance is hypothesized, which may also explain the sensitization of MDR cells with respect to non-MDR type drugs as well as sensitization of parental cells. copolymer 36-45 phosphoglycolate phosphatase Homo sapiens 67-71 15648254-8 2004 CONCLUSIONS: These data suggest that there are unifying pathways for the inhibition of Pgp and MRPs by the block copolymer. copolymer 113-122 phosphoglycolate phosphatase Homo sapiens 87-90 26952460-0 2016 Comb-like amphiphilic polypeptide-based copolymer nanomicelles for co-delivery of doxorubicin and P-gp siRNA into MCF-7 cells. copolymer 40-49 phosphoglycolate phosphatase Homo sapiens 98-102 32418316-6 2021 Moreover, the copolymer was able to induce lysosome membrane permeation (LMP) and increase Rh123 accumulation inside cells indicating inhibition of the P-gp efflux pumps. copolymer 14-23 phosphoglycolate phosphatase Homo sapiens 152-156 30408674-12 2019 It was also revealed that higher toxicity of the PTX-NPs could be due to ability of copolymer to inhibit P-gp pumps and induce lysosomal membrane permeabilization (LMP). copolymer 84-93 phosphoglycolate phosphatase Homo sapiens 105-109 29618203-3 2018 The MPEG-PLH-VES copolymer exerts no obvious effect on the P-gp expression level of MCF-7/ADR but exhibited a significant influence on the loss of mitochondrial membrane potential, the reduction of intracellular ATP level, and the inhibition of P-gp ATPase activity of MCF-7/ADR cells. copolymer 17-26 phosphoglycolate phosphatase Homo sapiens 245-249 18242899-1 2008 The aim of this work was to investigate the effects of pluronic F68 block copolymer on the P-gp-mediated transport of celiprolol (CEL) and CYP3A4-mediated formation of midazolam (MDZ) metabolite 1"-hydroxymidazolam. copolymer 74-83 phosphoglycolate phosphatase Homo sapiens 91-95 18393290-7 2008 In conclusion, this study provides evidence that a block-copolymer, Pluronic P85, effectively inhibits the interaction of P-gp with nelfinavir and saquinavir. copolymer 57-66 phosphoglycolate phosphatase Homo sapiens 122-126