PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15173009-1	2004	The activation of protein kinase G (PKG) by cGMP has become of considerable interest as a novel molecular mechanism for the induction of apoptosis in cancer cells, because sulindac sulfone (exisulind, Aptosyn) and certain derivatives that inhibit cGMP-phosphodiesterases and thereby increase cellular levels of cGMP appear to induce apoptosis via this mechanism.	sulindac sulfone	172-188	protein kinase cGMP-dependent 1	Homo sapiens	18-34	
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	82-98	protein kinase cGMP-dependent 1	Homo sapiens	318-334	
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	82-98	protein kinase cGMP-dependent 1	Homo sapiens	336-339	
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	111-118	protein kinase cGMP-dependent 1	Homo sapiens	318-334	
16166323-3	2005	There is extensive evidence that treatment of SW480 human colon cancer cells with sulindac sulfone (Exisulind, Aptosyn) or the related derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activity, causes an increase in intracellular levels of cGMP, thus activating protein kinase G (PKG), which then activates pathways that lead to apoptosis.	sulindac sulfone	111-118	protein kinase cGMP-dependent 1	Homo sapiens	336-339	
15173009-1	2004	The activation of protein kinase G (PKG) by cGMP has become of considerable interest as a novel molecular mechanism for the induction of apoptosis in cancer cells, because sulindac sulfone (exisulind, Aptosyn) and certain derivatives that inhibit cGMP-phosphodiesterases and thereby increase cellular levels of cGMP appear to induce apoptosis via this mechanism.	sulindac sulfone	172-188	protein kinase cGMP-dependent 1	Homo sapiens	36-39	
12492113-5	2002	CP248-induced VASP phosphorylation was inhibited by a specific PKG inhibitor but not by a protein kinase A inhibitor.	sulindac sulfone	0-5	protein kinase cGMP-dependent 1	Homo sapiens	63-66	
11051267-4	2000	Other compounds that increase cellular levels of cGMP also activated JNK1, and an inhibitor of protein kinase G (PKG), Rp-8-pCPT-cGMPS, inhibited JNK1 activation by the sulindac sulfone derivatives.	sulindac sulfone	169-185	protein kinase cGMP-dependent 1	Homo sapiens	95-111	
11051267-4	2000	Other compounds that increase cellular levels of cGMP also activated JNK1, and an inhibitor of protein kinase G (PKG), Rp-8-pCPT-cGMPS, inhibited JNK1 activation by the sulindac sulfone derivatives.	sulindac sulfone	169-185	protein kinase cGMP-dependent 1	Homo sapiens	113-116	
11051267-6	2000	Thus, it appears that sulindac sulfone and related compounds induce apoptosis, at least in part, through activation of PKG, which then activates the MEKK1-SEK1-JNK1 cascade.	sulindac sulfone	22-38	protein kinase cGMP-dependent 1	Homo sapiens	119-122	
11278263-1	2001	We recently obtained evidence that treatment of human colon cancer cells with exisulind (sulindac sulfone) and related compounds induces apoptosis by activation of protein kinase G (PKG) and c-Jun kinase (JNK1).	sulindac sulfone	89-105	protein kinase cGMP-dependent 1	Homo sapiens	164-180	
11278263-1	2001	We recently obtained evidence that treatment of human colon cancer cells with exisulind (sulindac sulfone) and related compounds induces apoptosis by activation of protein kinase G (PKG) and c-Jun kinase (JNK1).	sulindac sulfone	89-105	protein kinase cGMP-dependent 1	Homo sapiens	182-185