PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11051267-4	2000	Other compounds that increase cellular levels of cGMP also activated JNK1, and an inhibitor of protein kinase G (PKG), Rp-8-pCPT-cGMPS, inhibited JNK1 activation by the sulindac sulfone derivatives.	sulindac sulfone	169-185	mitogen-activated protein kinase 8	Homo sapiens	69-73	
11278263-1	2001	We recently obtained evidence that treatment of human colon cancer cells with exisulind (sulindac sulfone) and related compounds induces apoptosis by activation of protein kinase G (PKG) and c-Jun kinase (JNK1).	sulindac sulfone	89-105	mitogen-activated protein kinase 8	Homo sapiens	205-209	
11051267-2	2000	We found that sulindac sulfone and two potent derivatives, CP248 and CP461, inhibited the cyclic GMP (cGMP) phosphodiesterases (PDE) 2 and 5 in human colon cells, and these compounds caused rapid and sustained activation of the c-Jun NH2-terminal kinase 1 (JNK1).	sulindac sulfone	14-30	mitogen-activated protein kinase 8	Homo sapiens	228-255	
11051267-2	2000	We found that sulindac sulfone and two potent derivatives, CP248 and CP461, inhibited the cyclic GMP (cGMP) phosphodiesterases (PDE) 2 and 5 in human colon cells, and these compounds caused rapid and sustained activation of the c-Jun NH2-terminal kinase 1 (JNK1).	sulindac sulfone	14-30	mitogen-activated protein kinase 8	Homo sapiens	257-261	
11051267-2	2000	We found that sulindac sulfone and two potent derivatives, CP248 and CP461, inhibited the cyclic GMP (cGMP) phosphodiesterases (PDE) 2 and 5 in human colon cells, and these compounds caused rapid and sustained activation of the c-Jun NH2-terminal kinase 1 (JNK1).	sulindac sulfone	59-64	mitogen-activated protein kinase 8	Homo sapiens	228-255	
11051267-2	2000	We found that sulindac sulfone and two potent derivatives, CP248 and CP461, inhibited the cyclic GMP (cGMP) phosphodiesterases (PDE) 2 and 5 in human colon cells, and these compounds caused rapid and sustained activation of the c-Jun NH2-terminal kinase 1 (JNK1).	sulindac sulfone	59-64	mitogen-activated protein kinase 8	Homo sapiens	257-261	
11051267-4	2000	Other compounds that increase cellular levels of cGMP also activated JNK1, and an inhibitor of protein kinase G (PKG), Rp-8-pCPT-cGMPS, inhibited JNK1 activation by the sulindac sulfone derivatives.	sulindac sulfone	169-185	mitogen-activated protein kinase 8	Homo sapiens	146-150	
11051267-5	2000	Expression of a dominant-negative JNK1 protein inhibited CP248-induced cleavage of poly(ADP-ribose) polymerase, a marker of apoptosis.	sulindac sulfone	57-62	mitogen-activated protein kinase 8	Homo sapiens	34-38	
11051267-6	2000	Thus, it appears that sulindac sulfone and related compounds induce apoptosis, at least in part, through activation of PKG, which then activates the MEKK1-SEK1-JNK1 cascade.	sulindac sulfone	22-38	mitogen-activated protein kinase 8	Homo sapiens	160-164