PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14506281-4 2003 Spermidine/sperm-ine N1-acetyltransferase (SSAT) gene, which encodes a polyamine catabolic enzyme, was induced by clinically relevant sulindac sulfone concentrations. sulindac sulfone 134-150 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 0-41 14506281-4 2003 Spermidine/sperm-ine N1-acetyltransferase (SSAT) gene, which encodes a polyamine catabolic enzyme, was induced by clinically relevant sulindac sulfone concentrations. sulindac sulfone 134-150 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 43-47 14506281-8 2003 PPRE-2, at +48 bases relative to the transcription start site, is required for the induction of SSAT by sulindac sulfone and is specifically bound by PPAR gamma in the Caco-2 cells as shown by transfection and gel shift experiments. sulindac sulfone 104-120 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 96-100 14506281-12 2003 These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells. sulindac sulfone 45-61 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 153-157