PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10708429-4	2000	Polyene antibiotics such as amphotericin B have been shown to delay the accumulation of PrP(Sc) and to increase the incubation time of the disease after experimental transmission in laboratory animals.	Amphotericin B	28-42	prion protein	Mus musculus	88-91	
10708429-6	2000	We show here for the first time that amphotericin B can inhibit PrP(Sc) generation in scrapie-infected GT1-7 and N2a cells.	Amphotericin B	37-51	prion protein	Mus musculus	64-67	
7915757-2	1994	Recently it has been reported that amphotericin B (AmB) treatment of hamsters infected with scrapie strain 263K prolongs the incubation period of the disease, and dissociates in vivo replication of the scrapie agent from PrPSc accumulation.	Amphotericin B	35-49	prion protein	Mus musculus	221-226	
10646527-4	2000	Polyene antibiotics, such as amphotericin B, have been shown to delay the accumulation of PrP(Sc) and to increase the incubation time of the disease after experimental transmission in laboratory animals.	Amphotericin B	29-43	prion protein	Mus musculus	90-93	
10646527-5	2000	Unlike agents such as Congo red, the inhibitory effect of amphotericin B on PrP(Sc) generation has not been observed in infected cultures.	Amphotericin B	58-72	prion protein	Mus musculus	76-79	
10646527-6	2000	Using transfected cells expressing wild-type or mutated mouse PrPs, we show here that amphotericin B is able to interfere with the generation of abnormal PrP isoforms in culture.	Amphotericin B	86-100	prion protein	Mus musculus	62-65	
10074211-5	1999	The AmB effect against strain 263K was more prominent in mice whose endogenous PrP gene had been inactivated by homologous recombination.	Amphotericin B	4-7	prion protein	Mus musculus	79-82	
8837228-2	1996	The results show that (i) the treatment prolonged the incubation period of both BSE-infected and scrapie-infected mice, (ii) MS-8209 and AmB were much more efficient in delaying the onset of scrapie than that of BSE, and (iii) a delay in Prp-res (proteinase K-resistant prion protein) and GFAP (glial fibrillary acidic protein) accumulation was observed in the brains of scrapie-infected mice, but was not significant in BSE-infected mice.	Amphotericin B	137-140	prion protein	Mus musculus	238-241	
7915757-2	1994	Recently it has been reported that amphotericin B (AmB) treatment of hamsters infected with scrapie strain 263K prolongs the incubation period of the disease, and dissociates in vivo replication of the scrapie agent from PrPSc accumulation.	Amphotericin B	51-54	prion protein	Mus musculus	221-226	
7915757-6	1994	Results indicate that MS-8209 was as efficient as AmB in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model.	Amphotericin B	50-53	prion protein	Mus musculus	103-108	
7915757-9	1994	In long-term treatment of mice, MS-8209 and AmB markedly reduced PrPSc levels in the preclinical stage of the disease.	Amphotericin B	44-47	prion protein	Mus musculus	65-70