PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30381640-6	2018	Interestingly, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, an AMP-activated protein kinase activator, suppresses TNF-alpha-induced IRS-1 serine phosphorylation at 636/639 and the phosphorylation of ERK by enhancing interactions between ERK and dual-specificity phosphatase-9.	acadesine	15-69	tumor necrosis factor	Homo sapiens	125-134	
16636195-7	2006	A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), dose-dependently inhibited TNF-alpha- and interleukin-1beta-induced NF-kappaB reporter gene expression.	acadesine	79-84	tumor necrosis factor	Homo sapiens	114-123	
29247196-3	2017	The goal of this study was to evaluate the role of an AMP-dependent kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide riboside (AICAR), on tumor necrosis factor alpha (TNF-alpha) induction of complement factor B (CFB) in RPE cells.	acadesine	93-132	tumor necrosis factor	Homo sapiens	145-172	
29247196-3	2017	The goal of this study was to evaluate the role of an AMP-dependent kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide riboside (AICAR), on tumor necrosis factor alpha (TNF-alpha) induction of complement factor B (CFB) in RPE cells.	acadesine	93-132	tumor necrosis factor	Homo sapiens	174-183	
24669186-11	2014	In addition, we also found that pretreatment with the adenosine monophosphate-activated protein kinase (AMPK) agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside obviously inhibited TNF-alpha-induced proinflammatory cytokine production.	acadesine	118-172	tumor necrosis factor	Homo sapiens	193-202	
17513605-0	2007	5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.	acadesine	0-39	tumor necrosis factor	Homo sapiens	62-71	
28719670-4	2017	5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a potent activator of AMPK, significantly suppressed TNF-alpha and TGF-beta2-induced cellular aggregate formation (p < 0.01).	acadesine	0-54	tumor necrosis factor	Homo sapiens	117-126	
27170207-2	2016	The aim of this study was to determine whether 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an adenosine monophosphate-activated protein kinase (AMPK) activator, modulates these adipocytokine productions in tumor necrosis factor-alpha (TNFalpha)-treated adipocytes.	acadesine	47-101	tumor necrosis factor	Homo sapiens	226-253	
27170207-2	2016	The aim of this study was to determine whether 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an adenosine monophosphate-activated protein kinase (AMPK) activator, modulates these adipocytokine productions in tumor necrosis factor-alpha (TNFalpha)-treated adipocytes.	acadesine	47-101	tumor necrosis factor	Homo sapiens	255-263	
16636195-9	2006	The small interfering RNA for AMPKalpha1 attenuated metformin or AICAR-induced inhibition of NF-kappaB activation by TNF-alpha, suggesting a possible role of AMPK in the regulation of cell inflammation.	acadesine	65-70	tumor necrosis factor	Homo sapiens	117-126	
33362238-0	2020	Acadesine suppresses TNF-alpha induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.	acadesine	0-9	tumor necrosis factor	Homo sapiens	21-30	
33362238-4	2020	The purpose of this study was to evaluate if acadesine is able to suppress TNF-alpha induced C3 in RPE cells.	acadesine	45-54	tumor necrosis factor	Homo sapiens	75-84	
33362238-13	2020	CONCLUSIONS: Our results suggest that acadesine suppresses TNF-alpha induced C3, likely through an AMPK-independent pathway, and could have potential use in complement over activation diseases.	acadesine	38-47	tumor necrosis factor	Homo sapiens	59-68	
33362238-9	2020	RESULTS: Acadesine suppresses TNF-alpha induced C3 in a dose dependent manner.	acadesine	9-18	tumor necrosis factor	Homo sapiens	30-39