PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31071567-9	2019	More importantly, AICAR administration led to the significant enhancement of energy metabolism, elevation of AMPK as well as the decreased IL-6 and TNF-alpha in VAT of PM2.5-exposed mice, which suggesting that AMPK activation might attenuate the inflammatory responses in VAT via the inhibition of MAPKs and NFkappaB.	acadesine	18-23	interleukin 6	Mus musculus	139-143	
25711693-4	2015	Treatment with AICAR also inhibited the increase of myeloperoxidase (MPO), the induction of TNF-alpha, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide and the upregulation of matrix metalloproteinase 2 (MMP-2), MMP-3 and MMP-9 in mice exposed to CCl4.	acadesine	15-20	interleukin 6	Mus musculus	103-107	
16229818-6	2005	Pretreatment with p38 mitogen-activated protein kinase (MAPK) inhibitor blocked AICAR-induced IL-6 production; furthermore, AICAR-activated p38 MAPK phosphorylation by Western blot.	acadesine	80-85	interleukin 6	Mus musculus	94-98	
18818284-2	2009	Using 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR), a pharmacological activator of 5"-AMP-activated protein kinase (AMPK), we tested the hypothesis that AMPK modulates IL-6 release from isolated muscle.	acadesine	62-67	interleukin 6	Mus musculus	186-190	
18586954-5	2008	Exposure of LPS-stimulated neutrophils to AICAR or barberine inhibited release of TNF-alpha and IL-6, as well as degradation of IkappaBalpha and nuclear translocation of NF-kappaB, compared with findings in neutrophil cultures that contained LPS without AICAR or barberine.	acadesine	42-47	interleukin 6	Mus musculus	96-100