PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25594043-5 2014 Using the paired PC3 and PC3M cells to model progressive androgen-independent PC, treatment with either 5-aminoimidazole-4-carboxamide riboside (AICAR) or A-769662 suppressed proliferation, migration and invasion in both cell lines, and down-regulated mTOR and P70S6Ki levels regardless of the Akt status. acadesine 104-143 AKT serine/threonine kinase 1 Homo sapiens 294-297 25594043-5 2014 Using the paired PC3 and PC3M cells to model progressive androgen-independent PC, treatment with either 5-aminoimidazole-4-carboxamide riboside (AICAR) or A-769662 suppressed proliferation, migration and invasion in both cell lines, and down-regulated mTOR and P70S6Ki levels regardless of the Akt status. acadesine 145-150 AKT serine/threonine kinase 1 Homo sapiens 294-297 20167101-4 2010 Our results showed that 5-aminoimidazole-4-carboxamide-1 ribonucleoside (AICAR) greatly enhanced the ability of insulin to stimulate the insulin receptor substrate-1 (IRS1)-associated PI3K activity in differentiated 3T3-F442a adipocytes, leading to increased Akt phosphorylation at S473, whereas insulin-stimulated activation of mTOR was diminished. acadesine 73-78 AKT serine/threonine kinase 1 Homo sapiens 259-262 20185792-8 2010 CONCLUSION: Acadesine inhibits TF expression and thrombus formation by activating the phosphoinositide 3-kinase/Akt pathway. acadesine 12-21 AKT serine/threonine kinase 1 Homo sapiens 112-115 21867676-3 2011 An AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR), was observed to suppress the expression of the AQP9 gene in HepG2 cells by promoting the phosphorylation of AMPK and AKT/PKB. acadesine 75-80 AKT serine/threonine kinase 1 Homo sapiens 200-207 20185792-0 2010 Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. acadesine 0-9 AKT serine/threonine kinase 1 Homo sapiens 110-113 20185792-6 2010 In endothelial cells and macrophages, acadesine activated the phosphoinositide 3-kinase/Akt signaling pathway, reduced the activity of mitogen-activated protein kinases, and consequently suppressed TF expression by inhibiting the activator protein-1 and NF-kappaB pathways. acadesine 38-47 AKT serine/threonine kinase 1 Homo sapiens 88-91 17623090-10 2007 Additionally, AICAR treatment resulted in phosphorylation of Akt suggesting that activation of the PI3K/Akt pathway may represent a compensatory survival mechanism in response to apoptosis and/or cell cycle arrest. acadesine 14-19 AKT serine/threonine kinase 1 Homo sapiens 61-64 19639604-7 2009 Intriguingly, though activation of AMPK by 0.3 and 1.0 mM AICAR synergized IGF-1-induced Akt activation, the expression of UL was not attenuated, but strengthened by AMPK activation. acadesine 58-63 AKT serine/threonine kinase 1 Homo sapiens 89-92 17623090-10 2007 Additionally, AICAR treatment resulted in phosphorylation of Akt suggesting that activation of the PI3K/Akt pathway may represent a compensatory survival mechanism in response to apoptosis and/or cell cycle arrest. acadesine 14-19 AKT serine/threonine kinase 1 Homo sapiens 104-107 16620785-9 2006 These findings show that Akt dephosphorylation often occurs concomitantly with AMPK activation when cells are treated with phenformin or AICAR, indicating that these drugs do not only affect AMPK but also cause a coordinated inverse regulation of AMPK and Akt. acadesine 137-142 AKT serine/threonine kinase 1 Homo sapiens 25-28 16620785-9 2006 These findings show that Akt dephosphorylation often occurs concomitantly with AMPK activation when cells are treated with phenformin or AICAR, indicating that these drugs do not only affect AMPK but also cause a coordinated inverse regulation of AMPK and Akt. acadesine 137-142 AKT serine/threonine kinase 1 Homo sapiens 256-259 15806154-2 2005 Here we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reverses the sensitivity of Akt-expressing glioblastoma cells to glucose deprivation. acadesine 18-63 AKT serine/threonine kinase 1 Homo sapiens 100-103 15806154-2 2005 Here we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reverses the sensitivity of Akt-expressing glioblastoma cells to glucose deprivation. acadesine 65-70 AKT serine/threonine kinase 1 Homo sapiens 100-103 33329515-2 2020 In the current study, we found that both aspirin and 5-aminoimidazole-4-carboxamide-1-beta-riboside (AICAR) siginificantly attenuated virus replication by inhibiting BEFV-induced autophagy via suppressing the BEFV-activated PI3K/Akt/NF-kappaB and Src/JNK pathways as well as inducing reversion of the BEFV-suppressed PI3K-Akt-mTORC1 pathway. acadesine 101-106 AKT serine/threonine kinase 1 Homo sapiens 229-232 33329515-2 2020 In the current study, we found that both aspirin and 5-aminoimidazole-4-carboxamide-1-beta-riboside (AICAR) siginificantly attenuated virus replication by inhibiting BEFV-induced autophagy via suppressing the BEFV-activated PI3K/Akt/NF-kappaB and Src/JNK pathways as well as inducing reversion of the BEFV-suppressed PI3K-Akt-mTORC1 pathway. acadesine 101-106 AKT serine/threonine kinase 1 Homo sapiens 322-325 33329515-3 2020 AICAR reversed the BEFV-activated PI3K/Akt/NF-kappaB and Src/JNK pathways at the early to late stages of infection and induced reversion of the BEFV-suppressed PI3K-AKt-mTORC1 pathway at the late stage of infection. acadesine 0-5 AKT serine/threonine kinase 1 Homo sapiens 39-42 33329515-3 2020 AICAR reversed the BEFV-activated PI3K/Akt/NF-kappaB and Src/JNK pathways at the early to late stages of infection and induced reversion of the BEFV-suppressed PI3K-AKt-mTORC1 pathway at the late stage of infection. acadesine 0-5 AKT serine/threonine kinase 1 Homo sapiens 165-168