PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16364253-3	2006	Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR-stimulated increase in fatty acid oxidation.	acadesine	37-82	PPARG coactivator 1 alpha	Sus scrofa	147-152	
16364253-3	2006	Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR-stimulated increase in fatty acid oxidation.	acadesine	84-89	PPARG coactivator 1 alpha	Sus scrofa	147-152	
19005163-10	2009	The activation of AMPK using 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside increased PGC-1alpha promoter activity and mRNA levels but reduced ROS production.	acadesine	29-83	PPARG coactivator 1 alpha	Sus scrofa	94-104	
28556920-5	2017	In this study, we showed that AMPK activator acadesine (AICAR) alleviated INH-caused impairment of mitochondrial biogenesis by activation of silent information regulator two ortholog 1 (SIRT1)-peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1 alpha) pathway in HepG2 cells.	acadesine	45-54	PPARG coactivator 1 alpha	Sus scrofa	262-272