PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35241643-9 2022 AMPK activators metformin and 5-aminoimidazole-4-carboxamide (AICAR) hindered miR-146a expression at the transcriptional level by promoting IkappaB kinase (IKK) phosphorylation to attenuate nuclear factor-kappaB (NF-kappaB) activity. acadesine 62-67 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 34064363-0 2021 AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. acadesine 0-5 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 51-55 34064363-1 2021 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. acadesine 0-45 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 123-127 34064363-1 2021 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. acadesine 47-52 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 123-127 34064363-2 2021 The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer pathogenesis, were based solely on the use of AICAr as an AMPK-activator. acadesine 162-167 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 45-49 34064363-2 2021 The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer pathogenesis, were based solely on the use of AICAr as an AMPK-activator. acadesine 162-167 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 174-178 34064363-5 2021 This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on metabolism, hypoxia, exercise, nucleotide synthesis, and cancer, calling for caution in the interpretation of AICAr-based studies in the context of understanding AMPK signaling pathway. acadesine 112-117 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 65-69 34064363-5 2021 This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on metabolism, hypoxia, exercise, nucleotide synthesis, and cancer, calling for caution in the interpretation of AICAr-based studies in the context of understanding AMPK signaling pathway. acadesine 112-117 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 84-88 35254586-6 2022 Moreover, investigation of the effect of AMPK activity on PRRSV replication showed that PRRSV replication could be suppressed by the pharmacological agonists 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and A769662. acadesine 158-212 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 41-45 34418237-1 2021 This study was carried out with the objective to identify function prediction of novel microRNAs (miRNAs) in immature boar Sertoli cells (SCs) treated with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), which is an agonist of adenosine monophosphate-activated protein kinase (AMPK) for regulating cellular energy homeostasis. acadesine 212-217 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 243-291 34418237-1 2021 This study was carried out with the objective to identify function prediction of novel microRNAs (miRNAs) in immature boar Sertoli cells (SCs) treated with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), which is an agonist of adenosine monophosphate-activated protein kinase (AMPK) for regulating cellular energy homeostasis. acadesine 212-217 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 293-297 35217431-4 2022 We suppressed and increased the activities of AMPK with Dorsomorphin (CC) and Acadesine (AICAR), respectively. acadesine 78-87 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 46-50 34042039-6 2021 More specifically, we review the neuroprotective or neurodegenerative effects of AMPK or AMPK activators like metformin, resveratrol, and 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside on neurological diseases and dementia, which exert through the intracellular molecules involved in neuronal survival or death. acadesine 138-192 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 89-93 35135451-3 2022 5-aminoimidazole-4-carboxamide riboside (AICAR) is an analog of adenosine monophosphate and is a direct activator of AMPK. acadesine 0-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 117-121 35135451-3 2022 5-aminoimidazole-4-carboxamide riboside (AICAR) is an analog of adenosine monophosphate and is a direct activator of AMPK. acadesine 41-46 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 117-121 33362238-3 2020 Acadesine, an analog of AMP and an AMP-activated protein kinase (AMPK) activator, has been shown to have cytoprotective effects in human clinical trials as well as having anti-inflammatory and anti-vascular exudative effects in animals. acadesine 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 35-63 33362238-13 2020 CONCLUSIONS: Our results suggest that acadesine suppresses TNF-alpha induced C3, likely through an AMPK-independent pathway, and could have potential use in complement over activation diseases. acadesine 38-47 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 99-103 33362238-3 2020 Acadesine, an analog of AMP and an AMP-activated protein kinase (AMPK) activator, has been shown to have cytoprotective effects in human clinical trials as well as having anti-inflammatory and anti-vascular exudative effects in animals. acadesine 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 65-69 30847932-8 2019 Moreover, AMPK was activated with aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) or inhibited by AMPKalpha small interfering RNA (siRNA) to explore the role of AMPK in the modulation of connexin 43 (Cx43) and autophagy. acadesine 88-93 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 10-14 32588910-7 2020 Indeed, AMPK is activated during exercise and activation of AMPK by 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) increases skeletal muscle glucose uptake and fat oxidation. acadesine 116-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 8-12 32588910-7 2020 Indeed, AMPK is activated during exercise and activation of AMPK by 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) increases skeletal muscle glucose uptake and fat oxidation. acadesine 116-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 60-64 32561924-2 2020 The activation of 5"-adenosine monophosphate-activated protein kinase (AMPK) by 5-amino-4-imidazole carboxamide riboside-1-beta-d-ribofuranoside (AICAR) inhibits TGF-beta1-induced fibrosis in other cell types. acadesine 146-151 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-69 32561924-2 2020 The activation of 5"-adenosine monophosphate-activated protein kinase (AMPK) by 5-amino-4-imidazole carboxamide riboside-1-beta-d-ribofuranoside (AICAR) inhibits TGF-beta1-induced fibrosis in other cell types. acadesine 146-151 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 71-75 32561924-13 2020 Conclusions: AMPK activation by AICAR suppresses the myofibroblast differentiation and ECM synthesis that occur after alkali injury in corneal fibroblasts. acadesine 32-37 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 13-17 32913552-10 2020 Pretreatment with an AMPK agonist, 5-aminoimidazole-4-carboxamide-1-beta-D ribofuranoside, markedly enhanced autophagic activity and diminished apoptosis. acadesine 35-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 21-25 31008492-3 2019 The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and A-769662. acadesine 89-94 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-22 30724446-8 2019 Furthermore, 5-aminoimidazole-4-carboxamide ribonucleoside-induced AMPK activation improved VEGF expression in NiCl2 -treated H460 cells significantly. acadesine 13-58 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 67-71 30779249-4 2019 To further understand the regulation of miRNAs in the immature boar SC proliferation, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) was added to activate AMPK. acadesine 86-140 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 171-175 30987073-2 2019 AICAR (5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. acadesine 0-5 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 68-96 30987073-2 2019 AICAR (5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. acadesine 0-5 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 98-102 30987073-2 2019 AICAR (5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. acadesine 7-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 68-96 30987073-2 2019 AICAR (5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. acadesine 7-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 98-102 30987073-9 2019 In addition, our results demonstrated that AICAR induces apoptosis, attenuates transforming growth factor (TGF)-beta-induced cell migration, invasion and EMT-related protein expression, and enhances the chemosensitivity to docetaxel in prostate cancer cells through regulating the AMPK/mTOR-dependent pathway. acadesine 43-48 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 281-285 30779249-4 2019 To further understand the regulation of miRNAs in the immature boar SC proliferation, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) was added to activate AMPK. acadesine 142-147 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 171-175 29788824-8 2019 RESULTS: Resveratrol and AICAR increased AMPK phosphorylation in human placental explants. acadesine 25-30 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 41-45 29788824-15 2019 CONCLUSIONS: Activation of AMPK in the human placenta leads to global downregulation of metabolism, with mitotoxicity induced at the doses of resveratrol and AICAR used to activate AMPK. acadesine 158-163 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 27-31 29788824-15 2019 CONCLUSIONS: Activation of AMPK in the human placenta leads to global downregulation of metabolism, with mitotoxicity induced at the doses of resveratrol and AICAR used to activate AMPK. acadesine 158-163 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 181-185 29623826-7 2019 AMP, 5-Aminoimidazole-4-carboxamide riboside (AICA riboside) and A769662 are important activators of AMPK which have potential therapeutic importance in diabetes and diabetic complications. acadesine 46-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 101-105 30230919-2 2018 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an adenosine analog, is a standard positive control for AMPK activation in cell-based assays. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 120-124 30230919-2 2018 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an adenosine analog, is a standard positive control for AMPK activation in cell-based assays. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 120-124 30230919-5 2018 In nucleoside-free media, AICAR stimulated AMPK activation, increased glucose uptake, and suppressed cell proliferation. acadesine 26-31 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 43-47 30230919-8 2018 MEMalpha with nucleosides blocked AICAR-stimulated AMPK activation even in the presence of methotrexate, which normally markedly enhances AICAR action by reducing its intracellular clearance. acadesine 34-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 51-55 30253109-3 2018 Previous studies, which largely employed the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), suggest an antilipolytic role of AMPK in adipocytes. acadesine 60-114 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 157-161 30632675-5 2018 However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4. acadesine 38-91 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 25-29 30632675-5 2018 However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4. acadesine 38-91 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 134-138 30632675-5 2018 However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4. acadesine 93-98 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 25-29 30632675-5 2018 However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4. acadesine 93-98 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 134-138 30253109-3 2018 Previous studies, which largely employed the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), suggest an antilipolytic role of AMPK in adipocytes. acadesine 116-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 157-161 29247196-3 2017 The goal of this study was to evaluate the role of an AMP-dependent kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide riboside (AICAR), on tumor necrosis factor alpha (TNF-alpha) induction of complement factor B (CFB) in RPE cells. acadesine 93-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 54-74 30021848-5 2018 First, heart failure was induced in mice by 4 weeks of pressure overload; AMPK activation was subsequently induced by injecting 5-aminoimidazole-4-carboxamide 1-beta-d-ribonucleotide (AICAR) after the establishment of chronic heart failure. acadesine 184-189 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 74-78 29460119-8 2018 Furthermore, the specific AMPK activator AICAR (5-aminoimidazole-4-carboxamide 1-D-ribofuranoside) mimicked the effects of Curcumin, whereas a selective AMPK inhibitor Compound C (also called dorsomorphin) partially blocked its function. acadesine 41-46 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 26-30 29982462-5 2018 Chronic pharmacological activation of AMPK signaling in DM1 mice with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) has multiple beneficial effects on the DM1 phenotype. acadesine 70-124 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 29982462-5 2018 Chronic pharmacological activation of AMPK signaling in DM1 mice with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) has multiple beneficial effects on the DM1 phenotype. acadesine 126-131 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 29247196-3 2017 The goal of this study was to evaluate the role of an AMP-dependent kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide riboside (AICAR), on tumor necrosis factor alpha (TNF-alpha) induction of complement factor B (CFB) in RPE cells. acadesine 93-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 76-80 27847321-1 2017 AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, its activity in human gallbladder cancer cells was evaluated here. acadesine 7-46 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 67-95 28975042-3 2017 Our previous study demonstrated that AICAR alone induced AMPK-independent expression of differentiation markers in monocytic U937 leukemia cells, and no such effects were observed in response to metformin. acadesine 37-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 57-61 27847321-1 2017 AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, its activity in human gallbladder cancer cells was evaluated here. acadesine 7-46 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 97-101 27847321-1 2017 AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, its activity in human gallbladder cancer cells was evaluated here. acadesine 50-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 67-95 27847321-1 2017 AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) is an AMP-activated protein kinase (AMPK) agonist, its activity in human gallbladder cancer cells was evaluated here. acadesine 50-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 97-101 28683454-9 2017 The negative regulation loop between TLR4 and PPARgamma response to LPS was modulated by AMPK agonist AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) or A769662. acadesine 102-107 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 89-93 28683454-9 2017 The negative regulation loop between TLR4 and PPARgamma response to LPS was modulated by AMPK agonist AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) or A769662. acadesine 109-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 89-93 27521792-4 2016 The results showed that activation of AMPK with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) attenuated cardiomyocyte hypertrophy induced by angiotensin II (Ang II). acadesine 48-93 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 27170207-2 2016 The aim of this study was to determine whether 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an adenosine monophosphate-activated protein kinase (AMPK) activator, modulates these adipocytokine productions in tumor necrosis factor-alpha (TNFalpha)-treated adipocytes. acadesine 47-101 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 114-162 27170207-2 2016 The aim of this study was to determine whether 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an adenosine monophosphate-activated protein kinase (AMPK) activator, modulates these adipocytokine productions in tumor necrosis factor-alpha (TNFalpha)-treated adipocytes. acadesine 47-101 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 164-168 23933835-5 2013 METHODS: We compared protein kinase activities and alterations in lipogenic and gluconeogenic enzyme levels during activity of the AMPK activators metformin and AICAR, relative to those of an aPKC-iota inhibitor, in hepatocytes from non-diabetic and type 2 diabetic human organ donors. acadesine 161-166 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 131-135 26997114-9 2016 Pretreatment of GLP-1 reversed AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR)-induced apoptosis, and suppressed prolonged AMPK activation. acadesine 46-85 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 31-35 26997114-9 2016 Pretreatment of GLP-1 reversed AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR)-induced apoptosis, and suppressed prolonged AMPK activation. acadesine 87-92 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 31-35 26391395-1 2015 The key sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activated by the AMP analog aminoimidazolecarboxamide nucleoside monophosphate (ZMP) generated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synthesis by the antifolate pemetrexed (PTX), a drug used extensively in the treatment of lung cancers. acadesine 210-250 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 52-80 26391395-1 2015 The key sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activated by the AMP analog aminoimidazolecarboxamide nucleoside monophosphate (ZMP) generated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synthesis by the antifolate pemetrexed (PTX), a drug used extensively in the treatment of lung cancers. acadesine 210-250 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 82-86 26391395-1 2015 The key sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activated by the AMP analog aminoimidazolecarboxamide nucleoside monophosphate (ZMP) generated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synthesis by the antifolate pemetrexed (PTX), a drug used extensively in the treatment of lung cancers. acadesine 252-257 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 52-80 26391395-1 2015 The key sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activated by the AMP analog aminoimidazolecarboxamide nucleoside monophosphate (ZMP) generated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synthesis by the antifolate pemetrexed (PTX), a drug used extensively in the treatment of lung cancers. acadesine 252-257 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 82-86 26048992-6 2015 AMPK activators (5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside and metformin) decreased intracellular GlcCer levels and synthase activity in mouse fibroblasts. acadesine 17-71 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 26483453-6 2015 Indeed, activation of AMPK with 5-aminoimidazole-4-carboxamide riboside or salicylate increased nNOS S1412 phosphorylation and was sufficient to enhance NO production in mdx cardiomyocytes. acadesine 32-71 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 22-26 25778901-13 2015 Treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR, an AMPK activator) also provided cytoprotective effects against glucose deprivation. acadesine 15-69 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 25778901-13 2015 Treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR, an AMPK activator) also provided cytoprotective effects against glucose deprivation. acadesine 71-76 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 25842853-5 2014 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and Compound C (CC) were used to regulate AMPK activity. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 25842853-5 2014 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and Compound C (CC) were used to regulate AMPK activity. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 24669186-11 2014 In addition, we also found that pretreatment with the adenosine monophosphate-activated protein kinase (AMPK) agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside obviously inhibited TNF-alpha-induced proinflammatory cytokine production. acadesine 118-172 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 54-102 24669186-11 2014 In addition, we also found that pretreatment with the adenosine monophosphate-activated protein kinase (AMPK) agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside obviously inhibited TNF-alpha-induced proinflammatory cytokine production. acadesine 118-172 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 104-108 23933835-6 2013 RESULTS: Metformin and 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) activated aPKC at concentrations comparable with those required for AMPK activation. acadesine 79-84 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 154-158 23841933-6 2013 Activation of AMPK, which is induced by glucose deprivation, treatment with pharmacological agents such as 2-deoxy-D-glucose, metformin, and 5-aminoimidazole-4-carboxamide ribonucleoside or forced expression of a constitutively active AMPKalpha subunit, counteracts BDNF-induced phosphorylation of p70S6K and enhanced protein synthesis in cortical neurons. acadesine 141-186 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 23698161-4 2013 To determine whether AMP-activated protein kinase (AMPK) signaling may also directly regulate UCP3 expression, 5"-amino-4-imidazolecarboxamide-ribonucleoside (AICAR), an AMP analog that activates AMPK, was treated in C(2)C(12) muscle cells. acadesine 159-164 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 51-55 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 34-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 34-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 34-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 34-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 41-86 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 41-86 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 41-86 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 22751115-7 2013 AMPK activation by its activators AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) and metformin (N",N"-dimethylbiguanide), the most widely used antidiabetic drug, increased the expression of XPC and UVB-induced DNA repair in mouse skin, normal human epidermal keratinocytes, and AMPK wild-type (WT) cells but not in AMPK-deficient cells, indicating an AMPK-dependent mechanism. acadesine 41-86 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 285-289 23225245-7 2013 Meanwhile, compound C at concentrations sufficient to inhibit AMPK blocked this increase of glucose uptake by 2-BFI or AICAR. acadesine 119-124 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 62-66 23225245-5 2013 In the present study, 2-(2-benzofuranyl)-2-imidazoline (2-BFI) is used to stimulate I2R while 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is applied to activate AMPK directly. acadesine 94-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 180-184 23018889-5 2013 Recently, we showed that 8-Cl-cAMP and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibited cancer cell growth through the activation of AMPK and p38 MAPK. acadesine 39-84 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 148-152 23469683-0 2013 Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway. acadesine 25-64 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 128-132 23616923-9 2013 Increased osteoclast size induced by pyruvate (1 mM above basal levels) was prevented in the presence of AMPK activator 5-amino-4-imidazole carboxamide ribonucleotide (AICAR). acadesine 168-173 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 23469683-1 2013 The aim of this study was to demonstrate the effects of the AMP-activated protein kinase (AMPK) activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in combination with arsenic trioxide (ATO) in acute myeloid leukemia cells and determine its mechanism of action. acadesine 106-145 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 60-88 23469683-1 2013 The aim of this study was to demonstrate the effects of the AMP-activated protein kinase (AMPK) activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in combination with arsenic trioxide (ATO) in acute myeloid leukemia cells and determine its mechanism of action. acadesine 106-145 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 90-94 23469683-1 2013 The aim of this study was to demonstrate the effects of the AMP-activated protein kinase (AMPK) activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in combination with arsenic trioxide (ATO) in acute myeloid leukemia cells and determine its mechanism of action. acadesine 147-152 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 60-88 23469683-1 2013 The aim of this study was to demonstrate the effects of the AMP-activated protein kinase (AMPK) activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in combination with arsenic trioxide (ATO) in acute myeloid leukemia cells and determine its mechanism of action. acadesine 147-152 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 90-94 23469683-10 2013 The combination of AICAR and ATO produced a synergistic effect in the treatment of HL-60 cells involving AMPK/TSC2/mTOR pathway, and AICAR reduced ATO-mediated apoptotic death on acute promyelocytic leukemia NB4 cells. acadesine 19-24 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 22120676-6 2012 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a well-known AMPK activator, also inhibited tumor cell adhesion and invasion and reduced the expression of epithelial to mesenchymal transition (EMT)-related genes. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 77-81 21567395-6 2012 Pharmacological activation of AMPK by treatment with 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR), metformin, or adiponectin lowered TGF-beta-induced expression of COL1A and myofibroblast marker alpha-smooth muscle actin (alpha-SMA). acadesine 109-114 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 21567395-10 2012 Moreover, AICAR induced not only physical interaction between AMPK and p300 but also proteasomal degradation of p300 protein. acadesine 10-15 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 62-66 22120676-6 2012 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a well-known AMPK activator, also inhibited tumor cell adhesion and invasion and reduced the expression of epithelial to mesenchymal transition (EMT)-related genes. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 77-81 21956774-3 2012 The adenosine analog, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an AMPK activator used in many studies to assess the effects of AMPK activation on cellular metabolism and function. acadesine 34-88 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 103-107 21956774-3 2012 The adenosine analog, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an AMPK activator used in many studies to assess the effects of AMPK activation on cellular metabolism and function. acadesine 34-88 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 176-180 22740885-4 2012 Activation of AMPK by 5-aminoimidazole carboxamide ribonucleotide (AICAR) and phenformin elicited clear anti-proliferative effects in all breast cancer cell lines, but with differences in sensitivity. acadesine 67-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 20652679-5 2010 Moreover, the repression of AMPK activity by siRNA significantly reversed the inhibition of SAA expression by both AICAR and metformin, indicating that the effect of the agonists is dependent on AMPK. acadesine 115-120 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 28-32 22074809-4 2012 A favorable effect of AMPK activation on intima hyperplasia has been demonstrated in in vivo experimental models by using the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), or by studying the AMPKalpha(-/-) mice. acadesine 141-186 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 22-26 22074809-4 2012 A favorable effect of AMPK activation on intima hyperplasia has been demonstrated in in vivo experimental models by using the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), or by studying the AMPKalpha(-/-) mice. acadesine 188-193 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 22-26 22074809-4 2012 A favorable effect of AMPK activation on intima hyperplasia has been demonstrated in in vivo experimental models by using the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), or by studying the AMPKalpha(-/-) mice. acadesine 188-193 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 126-130 21470048-4 2011 Activation of AMPK by 5-amino-4-imidazolecarboxamide riboside (AICAr) or metformin as well as inactivation of AMPK by compound C (Comp C), siRNA ablation of AMPKalpha2, or exogenous ATP stimulated cardiomyogenesis of ES cells. acadesine 22-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 21470048-4 2011 Activation of AMPK by 5-amino-4-imidazolecarboxamide riboside (AICAr) or metformin as well as inactivation of AMPK by compound C (Comp C), siRNA ablation of AMPKalpha2, or exogenous ATP stimulated cardiomyogenesis of ES cells. acadesine 63-68 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 21228273-5 2011 AMP-activated protein kinase (AMPK) is the main ATP/AMP sensor of mammalian cells, and we mimicked an energy stress by treating human aortic smooth muscle cells (AoSMCs) with the AMPK activators 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin. acadesine 195-249 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 21228273-5 2011 AMP-activated protein kinase (AMPK) is the main ATP/AMP sensor of mammalian cells, and we mimicked an energy stress by treating human aortic smooth muscle cells (AoSMCs) with the AMPK activators 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin. acadesine 195-249 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 21228273-5 2011 AMP-activated protein kinase (AMPK) is the main ATP/AMP sensor of mammalian cells, and we mimicked an energy stress by treating human aortic smooth muscle cells (AoSMCs) with the AMPK activators 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin. acadesine 195-249 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 179-183 21944462-1 2011 PURPOSE: The nucleoside 5-aminoimidazole-4-carboxamide riboside (AICAR) is a low-energy mimetic and adenosine monophosphate (AMP)-activated protein kinase (AMPK) agonist that can affect the phenotype of malignant cells by diminishing their anabolism. acadesine 65-70 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 156-160 21697647-2 2011 AMPK is activated by conditions causing ATP depletion and by different metabolic molecules, such as adiponectin and AMPK agonist, such as 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 138-193 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 21697647-2 2011 AMPK is activated by conditions causing ATP depletion and by different metabolic molecules, such as adiponectin and AMPK agonist, such as 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 138-193 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 116-120 21697647-2 2011 AMPK is activated by conditions causing ATP depletion and by different metabolic molecules, such as adiponectin and AMPK agonist, such as 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 195-200 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 21697647-2 2011 AMPK is activated by conditions causing ATP depletion and by different metabolic molecules, such as adiponectin and AMPK agonist, such as 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 195-200 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 116-120 21464390-2 2011 In cultured human vascular smooth muscle cells, we observed that activation of AMPK by 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside inhibited agonist-induced phosphorylation of myosin light chain (MLC) and myosin phosphatase targeting subunit 1 (MYPT1). acadesine 87-141 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 79-83 21205922-0 2011 Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. acadesine 28-82 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-160 20652679-5 2010 Moreover, the repression of AMPK activity by siRNA significantly reversed the inhibition of SAA expression by both AICAR and metformin, indicating that the effect of the agonists is dependent on AMPK. acadesine 115-120 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 195-199 19656961-4 2009 Treatment with 5-amino-4-imidazolecarboxamide ribose (AICAR), a well-known activator of AMPK, induced phosphorylation of MAPK p38. acadesine 54-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 88-92 19617399-3 2010 AMPK activation after overnight treatment with either metformin (2-5 mM) or AICAR (1 mM) substantially inhibited ENaC-dependent I(sc) in both CF and non-CF airway cultures. acadesine 76-81 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 20615388-2 2010 We utilized 5-aminoimidazole-4-carboxamide riboside (AICAR) as a pharmacological activator of AMPK to unveil the effects of and signaling cascades mediated by AMPK on cyclooxygenase (COX)-2 gene expression in rat aortic vascular smooth muscle cells (VSMCs), murine macrophage cell line (J774), and human umbilical vein endothelial cells (HUVECs). acadesine 12-51 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 94-98 20615388-2 2010 We utilized 5-aminoimidazole-4-carboxamide riboside (AICAR) as a pharmacological activator of AMPK to unveil the effects of and signaling cascades mediated by AMPK on cyclooxygenase (COX)-2 gene expression in rat aortic vascular smooth muscle cells (VSMCs), murine macrophage cell line (J774), and human umbilical vein endothelial cells (HUVECs). acadesine 12-51 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 159-163 20490918-3 2010 In the present study, we report that the effect of AMPK activation induced by pretreatment with 5-aminoimidazole-4-carboxamide-1-b-4-ribofuranoside (AICAR) in neurons using the hypoxic model in vitro. acadesine 149-154 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 51-55 20430871-1 2010 The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [(3)H]-D-Phe-L-Gln was investigated in the human epithelial colon cancer cell line Caco-2. acadesine 14-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 86-114 20430871-1 2010 The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [(3)H]-D-Phe-L-Gln was investigated in the human epithelial colon cancer cell line Caco-2. acadesine 14-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 116-120 20430871-1 2010 The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [(3)H]-D-Phe-L-Gln was investigated in the human epithelial colon cancer cell line Caco-2. acadesine 61-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 86-114 20430871-1 2010 The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [(3)H]-D-Phe-L-Gln was investigated in the human epithelial colon cancer cell line Caco-2. acadesine 61-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 116-120 20177150-7 2010 In addition, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulated the nuclear translocation of GAPDH and prevented serum- and growth factor-induced GAPDH export. acadesine 13-67 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 93-121 20177150-7 2010 In addition, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulated the nuclear translocation of GAPDH and prevented serum- and growth factor-induced GAPDH export. acadesine 13-67 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 123-127 20177150-7 2010 In addition, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulated the nuclear translocation of GAPDH and prevented serum- and growth factor-induced GAPDH export. acadesine 69-74 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 93-121 20177150-7 2010 In addition, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulated the nuclear translocation of GAPDH and prevented serum- and growth factor-induced GAPDH export. acadesine 69-74 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 123-127 18671468-8 2008 AMPK-activating agents with high oral bioavailability have potential application in impaired glucose tolerance, insulin resistance and types 1 and 2 diabetes, however the poor oral bioavailability of acadesine precludes such application. acadesine 200-209 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 19571378-5 2009 The expression of GAPD mRNA decreased on treatment with an activator for AMPK, 5-amino-imidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 136-141 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 73-77 19299524-9 2009 Consistently, 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside, an AMPK activator, also had a cytoprotective and antioxidant effect against AA. acadesine 14-68 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 73-77 18798311-1 2009 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA riboside) has been extensively used in vitro and in vivo to activate the AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 134-162 18798311-1 2009 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA riboside) has been extensively used in vitro and in vivo to activate the AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 164-168 18798311-1 2009 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA riboside) has been extensively used in vitro and in vivo to activate the AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. acadesine 56-69 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 134-162 18798311-1 2009 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICA riboside) has been extensively used in vitro and in vivo to activate the AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. acadesine 56-69 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 164-168 18756496-5 2009 A potent agonist of AMPK, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) could also induce growth inhibition and apoptosis. acadesine 26-71 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 20-24 18756496-5 2009 A potent agonist of AMPK, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) could also induce growth inhibition and apoptosis. acadesine 73-78 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 20-24 23489075-4 2008 CONCLUSION: Evidence obtained using the AMPK-activating compound 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) suggests that AMPK promotes glucose transport into skeletal muscles and that this enzyme inhibits hepatic glucose production. acadesine 65-119 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 23489075-4 2008 CONCLUSION: Evidence obtained using the AMPK-activating compound 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) suggests that AMPK promotes glucose transport into skeletal muscles and that this enzyme inhibits hepatic glucose production. acadesine 65-119 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 142-146 23489075-4 2008 CONCLUSION: Evidence obtained using the AMPK-activating compound 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) suggests that AMPK promotes glucose transport into skeletal muscles and that this enzyme inhibits hepatic glucose production. acadesine 121-126 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 23489075-4 2008 CONCLUSION: Evidence obtained using the AMPK-activating compound 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) suggests that AMPK promotes glucose transport into skeletal muscles and that this enzyme inhibits hepatic glucose production. acadesine 121-126 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 142-146 18405894-4 2008 Activation of AMPK by metformin or 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased the rates of constitutive exocytosis by about 2-fold. acadesine 35-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 18406347-5 2008 Expression of AMPK or treatment with AICAR (5-aminoimidazole-4-carboxy-amide-1-d-ribofuranoside), an AMPK activator, activated the JNK/ATF3 pathways. acadesine 37-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 18406347-5 2008 Expression of AMPK or treatment with AICAR (5-aminoimidazole-4-carboxy-amide-1-d-ribofuranoside), an AMPK activator, activated the JNK/ATF3 pathways. acadesine 37-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 101-105 18405894-4 2008 Activation of AMPK by metformin or 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased the rates of constitutive exocytosis by about 2-fold. acadesine 91-96 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 18405894-5 2008 Stimulation of exocytosis by AMPK occurred within minutes, and persisted after overnight exposure to metformin or AICAR. acadesine 114-119 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 29-33 17615555-2 2008 In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level. acadesine 41-80 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 106-110 18248608-4 2008 Pharmacological activator of AMPK, 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuated the psychosine-mediated down-regulation of AMPK and restored altered biosynthesis of lipids. acadesine 91-96 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 29-33 18248608-4 2008 Pharmacological activator of AMPK, 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuated the psychosine-mediated down-regulation of AMPK and restored altered biosynthesis of lipids. acadesine 91-96 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 152-156 18174285-6 2008 The AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), induced phosphorylation of AMPK and significantly inhibited Pi-induced calcification in HASMC. acadesine 20-65 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 4-8 18174285-6 2008 The AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), induced phosphorylation of AMPK and significantly inhibited Pi-induced calcification in HASMC. acadesine 20-65 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-106 18174285-6 2008 The AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), induced phosphorylation of AMPK and significantly inhibited Pi-induced calcification in HASMC. acadesine 67-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 4-8 18174285-6 2008 The AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), induced phosphorylation of AMPK and significantly inhibited Pi-induced calcification in HASMC. acadesine 67-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-106 18195011-4 2008 Similar to oxidative stress, 5-aminoimidazole-4-carboxamide riboside (AICAR), a pharmacological activator of AMPK, inhibited RPE cell phagocytosis of POS in a dose-dependent manner. acadesine 29-68 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 109-113 18195011-4 2008 Similar to oxidative stress, 5-aminoimidazole-4-carboxamide riboside (AICAR), a pharmacological activator of AMPK, inhibited RPE cell phagocytosis of POS in a dose-dependent manner. acadesine 70-75 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 109-113 18195011-6 2008 In agreement, AICAR-induced activation of AMPK was abolished by preincubation with dipyridamole or 5-iodotubercidin. acadesine 14-19 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 42-46 17615555-2 2008 In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level. acadesine 82-87 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 106-110 17615555-6 2008 An adenosine kinase inhibitor 5"-iodotubercidin, which effectively abolished AMPK activation caused by AICAR, did not reverse the anti-inflammatory effect of AICAR. acadesine 103-108 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 77-81 16731851-7 2006 The AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mmol/l, 16 h) only partially decreased glucose-induced ROS by 22% (P<0.05). acadesine 19-73 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 4-8 17332500-8 2007 We also found that 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, a pharmacological AMPK activator in mammalian cells, mimics mitochondrial disease in impairing Dictyostelium phototaxis and that AMPKalpha antisense-inhibited cells were resistant to this effect. acadesine 19-73 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 93-97 17215282-4 2007 Using the AMPK-activating drug 5-amino-4-imidazolecarboxamide ribose (AICAR), we showed that, by 12 h post-HCMV infection, inhibition of mTOR by AMPK is circumvented. acadesine 70-75 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 145-149 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-130 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-130 17179149-1 2007 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAr), a commonly used indirect activator of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly isolated hepatocytes. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 16985054-4 2006 Methotrexate enhanced the AICA riboside-induced accumulation of ZMP and led to a decrease in the levels of ATP, which functions as an intrasteric inhibitor of AMPK. acadesine 26-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 159-163 17669398-2 2007 In this study, we show that the AMPK activators 5-aminoimidazole-4-carboxamide riboside (AICAr) and D942 inhibit cell growth in MM cell lines. acadesine 48-87 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 32-36 17669398-2 2007 In this study, we show that the AMPK activators 5-aminoimidazole-4-carboxamide riboside (AICAr) and D942 inhibit cell growth in MM cell lines. acadesine 89-94 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 32-36 17669398-3 2007 AICAr also induced an S-phase cell cycle arrest in all four tested cell lines and led to phosphorylation and thus activation of AMPK. acadesine 0-5 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 128-132 17215282-4 2007 Using the AMPK-activating drug 5-amino-4-imidazolecarboxamide ribose (AICAR), we showed that, by 12 h post-HCMV infection, inhibition of mTOR by AMPK is circumvented. acadesine 70-75 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 10-14 17496363-9 2007 These data, along with evidence from studies showing that chemical activation of AMPK in vivo with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) improves blood glucose concentrations and lipid profiles, make this enzyme an attractive pharmacological target for the treatment of type 2 diabetes and other metabolic disorders. acadesine 99-144 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 17496363-9 2007 These data, along with evidence from studies showing that chemical activation of AMPK in vivo with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) improves blood glucose concentrations and lipid profiles, make this enzyme an attractive pharmacological target for the treatment of type 2 diabetes and other metabolic disorders. acadesine 146-151 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 16943194-10 2006 Finally, evidence is provided that ZMP, a compound formed in 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-treated cells to activate AMPK in vivo, allosterically activates purified AMPK in vitro, but compared with AMP, maximal activity is not reached. acadesine 61-115 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 142-146 16943194-10 2006 Finally, evidence is provided that ZMP, a compound formed in 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-treated cells to activate AMPK in vivo, allosterically activates purified AMPK in vitro, but compared with AMP, maximal activity is not reached. acadesine 61-115 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 190-194 16731851-7 2006 The AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR; 1 mmol/l, 16 h) only partially decreased glucose-induced ROS by 22% (P<0.05). acadesine 75-80 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 4-8 17065104-4 2006 The results demonstrate that AICA riboside activates AMP-dependent protein kinase (AMPK), induces release of cytochrome c from mitochondria and activation of caspase 9. acadesine 29-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 53-81 16515522-6 2006 These data, along with evidence from studies showing that chemical activation of AMPK in vivo with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) improves blood glucose concentrations and lipid profiles, make this enzyme an attractive pharmacological target for the treatment of type 2 diabetes and other metabolic disorders. acadesine 99-144 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 16515522-6 2006 These data, along with evidence from studies showing that chemical activation of AMPK in vivo with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) improves blood glucose concentrations and lipid profiles, make this enzyme an attractive pharmacological target for the treatment of type 2 diabetes and other metabolic disorders. acadesine 146-151 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 17065104-4 2006 The results demonstrate that AICA riboside activates AMP-dependent protein kinase (AMPK), induces release of cytochrome c from mitochondria and activation of caspase 9. acadesine 29-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 83-87 16105857-2 2005 We previously reported that stimulation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased GLUT4 expression in muscle. acadesine 84-138 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 43-71 16105857-2 2005 We previously reported that stimulation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased GLUT4 expression in muscle. acadesine 84-138 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 73-77 16105857-2 2005 We previously reported that stimulation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased GLUT4 expression in muscle. acadesine 140-145 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 43-71 16105857-2 2005 We previously reported that stimulation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) increased GLUT4 expression in muscle. acadesine 140-145 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 73-77 15356065-4 2004 We also examined the effect of 5-aminoimidazole-4-carboxamide riboside (AICAR) on AMPK activity and the effects of AICAR and leptin on FA metabolism. acadesine 72-77 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 82-86 15860681-4 2005 Treatment of myotubes with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), followed by a 2-h recovery, augmented the ability of insulin to stimulate glucose transport. acadesine 46-100 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 31-35 15358229-3 2004 Inhibition of cell growth was observed when AMPK was activated by either 5-aminoimidazole-4-carboxamide riboside (AICAR) or the thiazolidinedione rosiglitazone. acadesine 73-112 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 44-48 15328001-2 2004 AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox. acadesine 27-73 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 14597982-8 2003 Insulin-independent activation of the AMPK using 5-aminoimidazole-4-carboxamide ribonucleoside, increased platelet eNOS phosphorylation, increased cyclic GMP levels and attenuated platelet aggregation. acadesine 49-94 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 12869384-8 2003 Inhibition of AMPK restored tissue responsiveness to forskolin, whereas stimulation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) induced tissue hyporesponsivness in wild-type mice. acadesine 97-151 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 87-91 12869384-8 2003 Inhibition of AMPK restored tissue responsiveness to forskolin, whereas stimulation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) induced tissue hyporesponsivness in wild-type mice. acadesine 153-158 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 87-91 12452797-6 2003 AICAriboside, when phosphorylated to AICAribotide (ZMP), is a specific activator of the AMP-activated protein kinase (AMPK) in certain cell types. acadesine 0-12 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 88-116 12522004-0 2003 Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. acadesine 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 20-24 12522004-4 2003 Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indicating that it is activated by acadesine. acadesine 31-40 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 72-120 12522004-4 2003 Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indicating that it is activated by acadesine. acadesine 31-40 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 122-126 12522004-4 2003 Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indicating that it is activated by acadesine. acadesine 164-173 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 72-120 12522004-4 2003 Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indicating that it is activated by acadesine. acadesine 164-173 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 122-126 12791703-3 2003 We therefore determined whether activation of AMPK with 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) stimulated NO production in human aortic endothelial cells. acadesine 56-102 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 46-50 12522004-5 2003 Nitrobenzylthioinosine (NBTI), a nucleoside transport inhibitor, 5-iodotubercidin, an inhibitor of adenosine kinase, and adenosine completely inhibited acadesine-induced apoptosis and AMPK phosphorylation, demonstrating that incorporation of acadesine into the cell and its subsequent phosphorylation to AICA ribotide (ZMP) are necessary to induce apoptosis. acadesine 152-161 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 184-188 12522004-11 2003 Intracellular levels of ZMP were higher in B-CLL cells than in T cells when both were treated with 0.5 mM acadesine, suggesting that ZMP accumulation is necessary to activate AMPK and induce apoptosis. acadesine 106-115 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 175-179 12452797-6 2003 AICAriboside, when phosphorylated to AICAribotide (ZMP), is a specific activator of the AMP-activated protein kinase (AMPK) in certain cell types. acadesine 0-12 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 118-122 11509493-5 2001 AMPK can also be activated chemically in resting muscle with 5-aminoimidazole-4-carboxamide-riboside, which enters the muscle and is phosphorylated to form ZMP, a nucleotide that mimics the effect of 5"-AMP. acadesine 61-100 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 12546682-3 2003 Recent experiments in AMPK transgenic mice suggest that glucose transport induced by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by AMPK. acadesine 85-124 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 22-26 12546682-3 2003 Recent experiments in AMPK transgenic mice suggest that glucose transport induced by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by AMPK. acadesine 85-124 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 159-163 12546682-3 2003 Recent experiments in AMPK transgenic mice suggest that glucose transport induced by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by AMPK. acadesine 126-131 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 22-26 12546682-3 2003 Recent experiments in AMPK transgenic mice suggest that glucose transport induced by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by AMPK. acadesine 126-131 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 159-163 12558800-3 2003 RESULTS: The treatment of SV40-immortalized human corneal epithelial cells (HCE-T cells) with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), widely used as an AMPK activator, inhibits p70 S6k activities. acadesine 94-139 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 167-171 12558800-3 2003 RESULTS: The treatment of SV40-immortalized human corneal epithelial cells (HCE-T cells) with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), widely used as an AMPK activator, inhibits p70 S6k activities. acadesine 141-146 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 167-171 12153572-5 2002 AMPK was activated under anoxic conditions or by incubation with 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAr) or oligomycin, an inhibitor of mitochondrial oxidative phosphorylation. acadesine 113-118 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 12476786-5 2002 Studies done in animal models of type 2 diabetes have shown that pharmacological activation of AMPK with the compound 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) decreases blood glucose and insulin concentrations. acadesine 118-163 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 95-99 12476786-5 2002 Studies done in animal models of type 2 diabetes have shown that pharmacological activation of AMPK with the compound 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) decreases blood glucose and insulin concentrations. acadesine 165-170 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 95-99 12417310-0 2002 Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. acadesine 87-126 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 55-83 12067722-2 2002 We have now found that amino acid-dependent phosphorylation of p70S6 kinase and of S6 in hepatocytes is prevented when AMP-dependent protein kinase (AMPK) is activated by either the purine ribonucleoside analogue AICAriboside, fructose or glycerol. acadesine 213-225 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 119-147 12067722-2 2002 We have now found that amino acid-dependent phosphorylation of p70S6 kinase and of S6 in hepatocytes is prevented when AMP-dependent protein kinase (AMPK) is activated by either the purine ribonucleoside analogue AICAriboside, fructose or glycerol. acadesine 213-225 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 149-153 11756336-6 2002 AMP-activated protein kinase (AMPK) activity was not diminished; however, incubation with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside increased AMPK activity twofold and completely prevented all of these changes. acadesine 109-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 11756336-6 2002 AMP-activated protein kinase (AMPK) activity was not diminished; however, incubation with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside increased AMPK activity twofold and completely prevented all of these changes. acadesine 109-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 11756336-6 2002 AMP-activated protein kinase (AMPK) activity was not diminished; however, incubation with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside increased AMPK activity twofold and completely prevented all of these changes. acadesine 109-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 94-98 11756336-6 2002 AMP-activated protein kinase (AMPK) activity was not diminished; however, incubation with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside increased AMPK activity twofold and completely prevented all of these changes. acadesine 109-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 94-98