PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19723101-4	2009	The low-dose H(2)O(2) stimulated COX-2 expression, and treating cells with synthetic AMPK activator AICAR (5-aminoimiazole-4-carboxamide-1-beta-d-ribofuranoside) resulted in greater suppression of COX-2 expression and PGE(2).	acadesine	100-105	prostaglandin-endoperoxide synthase 2	Homo sapiens	197-202	
17615555-2	2008	In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level.	acadesine	41-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-236	
17615555-2	2008	In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level.	acadesine	41-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	238-243	
17615555-2	2008	In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level.	acadesine	82-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-236	
17615555-2	2008	In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, inhibited lipopolysaccharide (LPS)-induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level.	acadesine	82-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	238-243	
17615555-5	2008	Regardless of the ability of AICAR to activate AMPK, the inhibitory effects of AICAR on iNOS and COX-2 expression were not associated with AMPK.	acadesine	79-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102	
34930349-6	2021	The expression of cyclooxygenase-2 (COX-2) induced by IL-1beta and suppressed by AICAR.	acadesine	81-86	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34	
34930349-6	2021	The expression of cyclooxygenase-2 (COX-2) induced by IL-1beta and suppressed by AICAR.	acadesine	81-86	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41	
17615555-0	2008	Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase.	acadesine	113-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-93