PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34727932-13 2021 However, this effect was mitigated by the AMPK agonist acadesine. acadesine 55-64 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 42-46 34727932-15 2021 C14 supplementation associated lipid accumulation by inhibiting the AMPK/ACC/CPT1 signaling pathway, aggravated myocardial lipotoxicity, increased apoptosis apart from cardiomyocyte hypertrophy and fibrosis were alleviated by the acadesine. acadesine 230-239 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 68-72 31431503-2 2019 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthesis and a well-established activator of AMP-activated protein kinase (AMPK), induces widespread metabolic alterations and is commonly used for dissecting the role of metabolism in cancer. acadesine 0-45 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 126-154 32986917-7 2020 Finally, the detection of proteins associated with the NF-kappaB/AMPK signaling pathway by western blot suggested that CCAL1 exerts its role on HC-OA cells by activating the NF-kappaB signaling pathway and inhibiting the AMPK signaling pathway, which was verified through the addition of NF-kappaB inhibitor caffeic acid phenethyl ester (CAPE) and AMPK activator 5-aminoimidazole-4carboxamide riboside (AICAR). acadesine 363-401 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 65-69 32986917-7 2020 Finally, the detection of proteins associated with the NF-kappaB/AMPK signaling pathway by western blot suggested that CCAL1 exerts its role on HC-OA cells by activating the NF-kappaB signaling pathway and inhibiting the AMPK signaling pathway, which was verified through the addition of NF-kappaB inhibitor caffeic acid phenethyl ester (CAPE) and AMPK activator 5-aminoimidazole-4carboxamide riboside (AICAR). acadesine 403-408 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 65-69 33002460-8 2020 Moreover, pretreatment of these cell lines with Acadesine or Dorsomorphin to activate or inhibit the AMPK-mTOR-ULK1 pathway, respectively, also resulting in promotion or suppression in both autophagy and apoptosis. acadesine 48-57 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 101-105 32898618-5 2020 After that, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), exercise mimic chemical that stimulates AMPK level, was also administered to Caco2 cells. acadesine 12-66 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 116-120 32898618-5 2020 After that, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), exercise mimic chemical that stimulates AMPK level, was also administered to Caco2 cells. acadesine 68-73 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 116-120 31431503-2 2019 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthesis and a well-established activator of AMP-activated protein kinase (AMPK), induces widespread metabolic alterations and is commonly used for dissecting the role of metabolism in cancer. acadesine 0-45 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 156-160 30251691-9 2018 The protective effect of NaHS or ALA was attenuated by rapamycin (an autophagy activator), 5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide (an AMPK activator) or PPG. acadesine 91-145 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 150-154 30468782-8 2019 Similarly, we demonstrated that a commonly used AMPK agonist 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) and fetal bovine serum (FBS) starvation, as a common model for energy stress, both led to Ampkalpha-independent metabolism alterations in MEF cells. acadesine 108-113 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 29688769-2 2018 The AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) interferes with inflammatory pathways in skeletal muscle, but the mechanisms are undefined. acadesine 75-80 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 4-8 27657826-3 2016 5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide (AICAR) is an agonist of AMPK. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 80-84 30002135-2 2018 Surprisingly, we found that, in beta-cells, the AMPK activator 5-amino-4-imidazolecarboxamide ribofuranoside (AICAR) inhibited, rather than stimulated, autophagy. acadesine 63-108 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 30002135-2 2018 Surprisingly, we found that, in beta-cells, the AMPK activator 5-amino-4-imidazolecarboxamide ribofuranoside (AICAR) inhibited, rather than stimulated, autophagy. acadesine 110-115 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 29546577-1 2018 AIMS: 5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. acadesine 6-45 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 84-88 29546577-1 2018 AIMS: 5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. acadesine 47-52 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 84-88 29773845-1 2018 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 110-138 29773845-1 2018 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 140-144 28174693-4 2017 Among the treatments tested, AMPK-activating 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) induced monoubiquitination and nuclear foci formation of FANCD2, which are biomarkers of FANCD2 activation. acadesine 45-90 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 29-33 28174693-4 2017 Among the treatments tested, AMPK-activating 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) induced monoubiquitination and nuclear foci formation of FANCD2, which are biomarkers of FANCD2 activation. acadesine 92-97 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 29-33 28556920-0 2017 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. acadesine 15-24 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 28445821-4 2017 Several derivatives of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. acadesine 23-77 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 90-118 28445821-4 2017 Several derivatives of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. acadesine 23-77 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 120-124 28445821-4 2017 Several derivatives of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. acadesine 79-84 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 90-118 28445821-4 2017 Several derivatives of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. acadesine 79-84 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 120-124 28978086-6 2017 In contrast, either autophagy activator rapamycin or AMPK activator acadesine (AICAR) compromised OA-induced anti-cancer effect. acadesine 68-77 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 53-57 27657826-3 2016 5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide (AICAR) is an agonist of AMPK. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 80-84 27657826-10 2016 These data suggested that fenoterol inhibited AICAR-induced AMPK activation and TNF-alpha release through beta-arrestin-2 in THP-1 cells. acadesine 46-51 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 60-64 27562249-5 2016 In a setting of hypoxia-potentiated inflammation induced by SFA palmitate, we found that the AMP-mimetic AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) potently suppressed upregulation of ER stress marker mRNAs and pro-inflammatory cytokines. acadesine 120-174 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 105-109 27062501-4 2016 AMPK activation by 5-aminoimidazole-4-carboxamide riboside, A769662 or C13 attenuated Kv 1.5 currents in pulmonary arterial myocytes, and this effect was non-additive with respect to Kv 1.5 inhibition by hypoxia and mitochondrial poisons. acadesine 19-58 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 27062501-10 2016 Myocyte Kv currents were also markedly inhibited upon AMPK activation by A769662, 5-aminoimidazole-4-carboxamide riboside and C13 and by intracellular dialysis from a patch-pipette of activated (thiophosphorylated) recombinant AMPK heterotrimers (alpha2beta2gamma1 or alpha1beta1gamma1). acadesine 82-121 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 54-58 25360075-0 2014 5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways. acadesine 0-39 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 66-94 26194078-8 2015 In cells treated with the AMPK activator 5-aminoidazole-4-carboxamide ribonucleotide (AICAR), the expression of hepatic SEPP1 and fetuin-A were negatively related by AMPK, which is the target of exendin-4. acadesine 86-91 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 26-30 26194078-8 2015 In cells treated with the AMPK activator 5-aminoidazole-4-carboxamide ribonucleotide (AICAR), the expression of hepatic SEPP1 and fetuin-A were negatively related by AMPK, which is the target of exendin-4. acadesine 86-91 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 166-170 25428125-4 2015 Activation of AMPK by 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) inhibited high glucose-induced and TGF-beta stimulation of nuclear Smad4. acadesine 22-76 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 25428125-4 2015 Activation of AMPK by 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) inhibited high glucose-induced and TGF-beta stimulation of nuclear Smad4. acadesine 78-83 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 25354528-7 2015 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR)-mediated activation of AMPK phosphorylated acetyl-CoA carboxylase, but treatment with AICAR or other AMPK activators (A769662, phenformin) did not restore ULK1 phosphorylation or autophagosome formation. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 86-90 25354528-7 2015 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR)-mediated activation of AMPK phosphorylated acetyl-CoA carboxylase, but treatment with AICAR or other AMPK activators (A769662, phenformin) did not restore ULK1 phosphorylation or autophagosome formation. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 86-90 25354528-7 2015 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR)-mediated activation of AMPK phosphorylated acetyl-CoA carboxylase, but treatment with AICAR or other AMPK activators (A769662, phenformin) did not restore ULK1 phosphorylation or autophagosome formation. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 164-168 25315694-4 2014 Here we show that AMP-activated protein kinase (AMPK) activation by AICAR (5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide) or phenformin induced the ubiquitination of FSP27 and promoted its degradation in 3T3-L1 adipocytes. acadesine 68-73 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 18-46 25315694-4 2014 Here we show that AMP-activated protein kinase (AMPK) activation by AICAR (5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide) or phenformin induced the ubiquitination of FSP27 and promoted its degradation in 3T3-L1 adipocytes. acadesine 68-73 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 25315694-4 2014 Here we show that AMP-activated protein kinase (AMPK) activation by AICAR (5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide) or phenformin induced the ubiquitination of FSP27 and promoted its degradation in 3T3-L1 adipocytes. acadesine 75-129 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 18-46 25315694-4 2014 Here we show that AMP-activated protein kinase (AMPK) activation by AICAR (5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide) or phenformin induced the ubiquitination of FSP27 and promoted its degradation in 3T3-L1 adipocytes. acadesine 75-129 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 26614120-11 2016 Consistently, pharmacological AMPK activation with 5-aminoimidazole-4-carboxamide riboside (AICAR) in mouse muscle did not affect the LC3-II/LC3-I ratio. acadesine 51-90 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 30-34 26614120-11 2016 Consistently, pharmacological AMPK activation with 5-aminoimidazole-4-carboxamide riboside (AICAR) in mouse muscle did not affect the LC3-II/LC3-I ratio. acadesine 92-97 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 30-34 24555415-4 2014 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, was used to determine the regulatory role of AMPK on HCC adhesion to the endothelium in regard to the resistin effects. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 67-95 24555415-4 2014 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, was used to determine the regulatory role of AMPK on HCC adhesion to the endothelium in regard to the resistin effects. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 97-101 24555415-4 2014 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, was used to determine the regulatory role of AMPK on HCC adhesion to the endothelium in regard to the resistin effects. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 97-101 24555415-4 2014 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, was used to determine the regulatory role of AMPK on HCC adhesion to the endothelium in regard to the resistin effects. acadesine 56-61 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 67-95 23863464-3 2013 Here, we demonstrate that treatment of rabbit isolated, perfused collecting ducts with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibited V-ATPase-dependent H(+) secretion from intercalated cells after an acid load. acadesine 106-160 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 91-95 23863464-3 2013 Here, we demonstrate that treatment of rabbit isolated, perfused collecting ducts with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibited V-ATPase-dependent H(+) secretion from intercalated cells after an acid load. acadesine 162-167 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 91-95 23625915-5 2013 Activation of AMPK using 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) resulted in STIM1 phosphorylation on serine residues and prevented protease-activated receptor-1 (PAR-1)-induced Ca(2+) entry. acadesine 81-86 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 23625915-5 2013 Activation of AMPK using 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) resulted in STIM1 phosphorylation on serine residues and prevented protease-activated receptor-1 (PAR-1)-induced Ca(2+) entry. acadesine 25-79 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 23525626-6 2013 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, an AMPK activator, also induced HO-1 expression. acadesine 0-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 59-63 23019413-5 2012 Phosphorylation of adenosine monophosphate (AMP)-activated protein kinase alpha1 (AMPKalpha1) was increased by both drugs, which promoted cell survival, as indicated by results obtained using AMPK inhibitor compound C and AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside. acadesine 237-291 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 82-92 22704782-5 2013 CLA isomers showed synergistic effects with the AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR). acadesine 120-125 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-52 23019413-5 2012 Phosphorylation of adenosine monophosphate (AMP)-activated protein kinase alpha1 (AMPKalpha1) was increased by both drugs, which promoted cell survival, as indicated by results obtained using AMPK inhibitor compound C and AMPK activator 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside. acadesine 237-291 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 82-86 21217782-6 2011 Thus, we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of AMPK, increases the abundance of LITAF and TNFSF15 in LNCaP and C4-2 prostate cancer cells, which is abrogated by small hairpin RNA (shRNA) or the dominant-negative mutant of AMPK alpha1 subunit. acadesine 19-64 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 105-109 21217782-6 2011 Thus, we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of AMPK, increases the abundance of LITAF and TNFSF15 in LNCaP and C4-2 prostate cancer cells, which is abrogated by small hairpin RNA (shRNA) or the dominant-negative mutant of AMPK alpha1 subunit. acadesine 19-64 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 280-291 21217782-6 2011 Thus, we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of AMPK, increases the abundance of LITAF and TNFSF15 in LNCaP and C4-2 prostate cancer cells, which is abrogated by small hairpin RNA (shRNA) or the dominant-negative mutant of AMPK alpha1 subunit. acadesine 66-71 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 105-109 21217782-6 2011 Thus, we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of AMPK, increases the abundance of LITAF and TNFSF15 in LNCaP and C4-2 prostate cancer cells, which is abrogated by small hairpin RNA (shRNA) or the dominant-negative mutant of AMPK alpha1 subunit. acadesine 66-71 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 280-291 21037234-2 2011 Treatment of human ECs with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) stimulated a concentration- and time-dependent increase in HO-1 protein and mRNA expression that was associated with a prominent increase in nuclear factor-erythroid 2-related factor 2 (Nrf2) protein. acadesine 47-101 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 32-36 21037234-4 2011 Induction of HO-1 by AICAR was blocked by the AMPK inhibitor compound C, the adenosine kinase inhibitor 5"-iodotubercidin, and by silencing AMPK-alpha(1/2) and was mimicked by the AMPK activator A-769662 and by infecting ECs with an adenovirus expressing constitutively active AMPK-alpha(1). acadesine 21-26 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 140-144 21037234-2 2011 Treatment of human ECs with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) stimulated a concentration- and time-dependent increase in HO-1 protein and mRNA expression that was associated with a prominent increase in nuclear factor-erythroid 2-related factor 2 (Nrf2) protein. acadesine 103-108 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 32-36 21037234-4 2011 Induction of HO-1 by AICAR was blocked by the AMPK inhibitor compound C, the adenosine kinase inhibitor 5"-iodotubercidin, and by silencing AMPK-alpha(1/2) and was mimicked by the AMPK activator A-769662 and by infecting ECs with an adenovirus expressing constitutively active AMPK-alpha(1). acadesine 21-26 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 46-50 21037234-4 2011 Induction of HO-1 by AICAR was blocked by the AMPK inhibitor compound C, the adenosine kinase inhibitor 5"-iodotubercidin, and by silencing AMPK-alpha(1/2) and was mimicked by the AMPK activator A-769662 and by infecting ECs with an adenovirus expressing constitutively active AMPK-alpha(1). acadesine 21-26 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 140-144 21037234-4 2011 Induction of HO-1 by AICAR was blocked by the AMPK inhibitor compound C, the adenosine kinase inhibitor 5"-iodotubercidin, and by silencing AMPK-alpha(1/2) and was mimicked by the AMPK activator A-769662 and by infecting ECs with an adenovirus expressing constitutively active AMPK-alpha(1). acadesine 21-26 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 140-144 19347029-7 2009 Conversely, treatment of the C4-2 cells with 5-aminoimidazole-4-carboxamide 1-D-ribonucleoside (AICAR), a prototypical AMPK activator, caused opposite changes. acadesine 96-101 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 119-123 20686348-4 2010 Treatment of the cells with AICAR (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside), an AMPK activator, reduced the methylmercury toxicity. acadesine 28-33 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 95-99 20686348-4 2010 Treatment of the cells with AICAR (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside), an AMPK activator, reduced the methylmercury toxicity. acadesine 35-89 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 95-99 20133456-9 2010 An in vivo study showed that prolonged 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced AMPK activation increases uncoupling protein 1 expression and induces an accumulation of brown adipocytes in white adipose tissue (WAT), as revealed by immunohistology. acadesine 39-84 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 101-105 20133456-9 2010 An in vivo study showed that prolonged 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced AMPK activation increases uncoupling protein 1 expression and induces an accumulation of brown adipocytes in white adipose tissue (WAT), as revealed by immunohistology. acadesine 86-91 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 101-105 19639604-7 2009 Intriguingly, though activation of AMPK by 0.3 and 1.0 mM AICAR synergized IGF-1-induced Akt activation, the expression of UL was not attenuated, but strengthened by AMPK activation. acadesine 58-63 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 35-39 19262472-3 2009 Although the chemical reagent 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) has been used to stimulate AMPK activity, AICAR has been associated with several nonspecific reactions. acadesine 30-84 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 120-124 19261894-6 2009 Interestingly, pharmacological activation of AMPK with AICAR (5-aminoimidazole-4-carboxamide riboside) alone also increased GLUT3 surface expression, with a hyperpolarization of Delta psi(m) evident in many neurons. acadesine 55-60 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 45-49 19261894-6 2009 Interestingly, pharmacological activation of AMPK with AICAR (5-aminoimidazole-4-carboxamide riboside) alone also increased GLUT3 surface expression, with a hyperpolarization of Delta psi(m) evident in many neurons. acadesine 62-101 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 45-49 19052260-9 2009 Finally, treating NuLi monolayers with the membrane permeant AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) caused a significant decrease of the KCa3.1-mediated short-circuit currents, an effect reversible by coincubation with the AMPK inhibitor Compound C. These observations argue for a regulation of KCa3.1 by AMPK in a functional epithelium through protein/protein interactions involving the gamma1-subunit of AMPK. acadesine 132-137 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 61-65 19052260-9 2009 Finally, treating NuLi monolayers with the membrane permeant AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) caused a significant decrease of the KCa3.1-mediated short-circuit currents, an effect reversible by coincubation with the AMPK inhibitor Compound C. These observations argue for a regulation of KCa3.1 by AMPK in a functional epithelium through protein/protein interactions involving the gamma1-subunit of AMPK. acadesine 132-137 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 262-266 19052260-9 2009 Finally, treating NuLi monolayers with the membrane permeant AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) caused a significant decrease of the KCa3.1-mediated short-circuit currents, an effect reversible by coincubation with the AMPK inhibitor Compound C. These observations argue for a regulation of KCa3.1 by AMPK in a functional epithelium through protein/protein interactions involving the gamma1-subunit of AMPK. acadesine 132-137 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 262-266 19052260-9 2009 Finally, treating NuLi monolayers with the membrane permeant AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) caused a significant decrease of the KCa3.1-mediated short-circuit currents, an effect reversible by coincubation with the AMPK inhibitor Compound C. These observations argue for a regulation of KCa3.1 by AMPK in a functional epithelium through protein/protein interactions involving the gamma1-subunit of AMPK. acadesine 132-137 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 262-266 19262472-3 2009 Although the chemical reagent 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) has been used to stimulate AMPK activity, AICAR has been associated with several nonspecific reactions. acadesine 86-91 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 120-124 17603555-1 2007 BACKGROUND AND PURPOSE: AMP-activated protein kinase (AMPK) is activated by metformin, phenformin, and the AMP mimetic, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). acadesine 120-174 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 54-58 17513706-1 2007 Activation of AMP-activated protein kinase (AMPK) in rodent muscle by exercise, metformin, 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), and adiponectin increases glucose uptake. acadesine 91-145 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 44-48 16636195-7 2006 A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), dose-dependently inhibited TNF-alpha- and interleukin-1beta-induced NF-kappaB reporter gene expression. acadesine 79-84 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 31-35 16870829-5 2007 Exposure of cells to 5-aminoimidazole-4-carboxamide-1beta-D-ribofuranoside (an AMPK activator) increased insulin action in uninfected myotubes and myotubes transduced with green fluorescent protein but not in Ad-AMPK-DN-infected myotubes. acadesine 21-74 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 79-83 17617726-3 2007 The present study was designed to examine the effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR)-induced AMPK signaling on effector mechanisms of myofibrillar protein degradation and the expression of atrophy-related genes (atrogin-1/MAFbx, MuRF1, proteasome C2 subunit, calpains, cathepsin B, and caspase-3) in C2C12 myotubes. acadesine 112-117 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 127-131 16636195-9 2006 The small interfering RNA for AMPKalpha1 attenuated metformin or AICAR-induced inhibition of NF-kappaB activation by TNF-alpha, suggesting a possible role of AMPK in the regulation of cell inflammation. acadesine 65-70 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 30-40 16636195-9 2006 The small interfering RNA for AMPKalpha1 attenuated metformin or AICAR-induced inhibition of NF-kappaB activation by TNF-alpha, suggesting a possible role of AMPK in the regulation of cell inflammation. acadesine 65-70 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 30-34 15928020-3 2005 It was revealed that the stimulation with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and 2,4-dinitrophenol (DNP), known activators of AMPK, promptly accelerates its translocation within 4 min, as was found in the case of insulin stimulation. acadesine 98-103 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 154-158 15928020-3 2005 It was revealed that the stimulation with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and 2,4-dinitrophenol (DNP), known activators of AMPK, promptly accelerates its translocation within 4 min, as was found in the case of insulin stimulation. acadesine 42-96 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 154-158 15033479-1 2004 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) can be used as an experimental tool to activate 5"-AMP-activated protein kinase (AMPK) and has been shown to improve insulin sensitivity. acadesine 0-45 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 135-139 15919715-0 2005 Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. acadesine 15-69 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 92-120 15919715-0 2005 Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. acadesine 71-76 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 92-120 15919715-7 2005 The AMP mimetic drug 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) also activates AMPK in intact cells. acadesine 21-75 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 99-103 15919715-7 2005 The AMP mimetic drug 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) also activates AMPK in intact cells. acadesine 77-82 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 99-103 15769985-5 2005 In lean myotubes, gAD activates AMPKalpha1 and -alpha2 by increasing Thr172 phosphorylation, an effect associated with increased acetyl-coenzyme A carboxylase (ACCbeta) Ser221 phosphorylation and enhanced rates of fatty acid oxidation, effects similar to those observed after pharmacological AMPK activation by 5-aminoimidazole-4-carboxamide riboside. acadesine 311-350 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 32-54 15294043-6 2004 Activating AMPK using 5-aminoimidizole-4-carboxamide-1-beta-D-riboside (AICAR) and increasing cytoplasmic Ca(2+) using caffeine, W7 or ionomycin in L6 myotubes increases the concentration of mitochondrial enzymes and GLUT4 and enhances the binding of NRF-1 and NRF-2 to DNA. acadesine 72-77 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 11-15 14573616-1 2004 We investigated the importance of the two catalytic alpha-isoforms of the 5"-AMP-activated protein kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) and contraction-induced glucose uptake in skeletal muscle. acadesine 172-177 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 74-105 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 0-39 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 77-105 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 0-39 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 107-111 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 41-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 77-105 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 41-54 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 107-111 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 56-65 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 77-105 15009683-1 2004 5-Aminoimidazole-4-carboxamide riboside (AICA riboside; Acadesine) activates AMP-activated protein kinase (AMPK) in intact cells, and is reported to exert protective effects in the mammalian CNS. acadesine 56-65 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 107-111 15009683-6 2004 We conclude that metabolic stress and AICA riboside both stimulate AMPK activity in mammalian brain, but that AICA riboside has an additional effect, i.e. competition with adenosine for uptake by the nucleoside transporter. acadesine 38-51 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 67-71 14573616-1 2004 We investigated the importance of the two catalytic alpha-isoforms of the 5"-AMP-activated protein kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) and contraction-induced glucose uptake in skeletal muscle. acadesine 172-177 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 107-111 14573616-11 2004 The results show that alpha2-AMPK is the main donor of basal and AICAR-stimulated AMPK activity and is responsible for AICAR-induced glucose uptake. acadesine 65-70 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 29-33 14573616-11 2004 The results show that alpha2-AMPK is the main donor of basal and AICAR-stimulated AMPK activity and is responsible for AICAR-induced glucose uptake. acadesine 65-70 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 82-86 14500570-7 2003 Recent studies suggest that the ability of leptin, adiponectin, 5"-aminoimidazole 4-carboxamide riboside (AICAR), adrenergic agonists, and metformin to diminish adiposity may be mediated, at least in part, by AMPK activation in peripheral tissues. acadesine 64-104 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 209-213 14500570-7 2003 Recent studies suggest that the ability of leptin, adiponectin, 5"-aminoimidazole 4-carboxamide riboside (AICAR), adrenergic agonists, and metformin to diminish adiposity may be mediated, at least in part, by AMPK activation in peripheral tissues. acadesine 106-111 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 209-213 12519745-6 2003 Activation of endogenous AMPK with the cell-permeant adenosine analog 5-amino-4-imidazolecarboxamide-1-beta-d-ribofuranoside (AICAR) inhibited forskolin-stimulated CFTR-dependent I(sc) in nonpermeabilized monolayers and monolayers with nystatin permeabilization of the basolateral membrane. acadesine 126-131 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 25-29 12051742-8 2002 In an insulinoma cell line, either low glucose or 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) treatment leads to activation and T172 phosphorylation of endogenous AMPK. acadesine 50-95 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 173-177 12051742-8 2002 In an insulinoma cell line, either low glucose or 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) treatment leads to activation and T172 phosphorylation of endogenous AMPK. acadesine 97-102 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 173-177 12502487-7 2003 Activation of AMPK by either 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) or hydrogen peroxide was also associated with a decrease in the activity ratio of GS. acadesine 29-83 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18 12502487-7 2003 Activation of AMPK by either 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) or hydrogen peroxide was also associated with a decrease in the activity ratio of GS. acadesine 85-90 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 14-18