PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18801339-7 2008 A central role for AMP-dependent kinase as a mediator of leptin"s action is demonstrated by the ability of 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR) to decrease tau phosphorylation, and by blocking leptin in the presence of Compound C. Thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for Alzheimer"s disease. acadesine 155-160 amyloid beta precursor protein Homo sapiens 286-298