PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17997161-6	2008	Interestingly, PGN-induced IL-8 expression was inhibited by nystatin, a specific inhibitor for lipid rafts, but not by chlorpromazine, a specific inhibitor for clathrin-coated pits.	Nystatin	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	27-31	
19786303-3	2009	IL-8 expression was inhibited by nystatin (a lipid rafts inhibitor) but not by chlorpromazine (a clathrin-coated pits inhibitor).	Nystatin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
16048981-0	2005	Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.	Nystatin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	54-58	
16048981-2	2005	Herein, we demonstrate that nystatin induces interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2.	Nystatin	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	69-73	
34438042-4	2021	The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8.	Nystatin	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	147-151	
29145158-6	2018	rOmpU-induced IL-8 expression was inhibited by interference of lipid raft formation with nystatin, but not by blocking the formation of clathrin-coated pits with chlorpromazine.	Nystatin	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	14-18	
23831464-0	2013	Differential regulation of CC chemokine ligand 2 and CXCL8 by antifungal agent nystatin in macrophages.	Nystatin	79-87	C-X-C motif chemokine ligand 8	Homo sapiens	53-58	
23831464-4	2013	However, nystatin dose-dependently increased CCL2 and CXCL8 expression at the mRNA and protein levels.	Nystatin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	54-59	
23831464-5	2013	To understand the molecular mechanisms of the antifungal agent, we identified cellular factors activated by nystatin and those involved in nystatin-induced upregulation of CCL2 and CXCL8.	Nystatin	139-147	C-X-C motif chemokine ligand 8	Homo sapiens	181-186	
23831464-8	2013	Nystatin-mediated CXCL8 expression was attenuated in the presence of Akt inhibitor IV and SP6001250.	Nystatin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-23	
23831464-9	2013	These results indicate that exposure of human macrophages to nystatin can lead to differential regulation of CCL2 and CXCL8 via the activation of multiple cellular kinases.	Nystatin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	118-123	
23831464-10	2013	We propose that upregulation of CCL2 and CXCL8 contributes to pharmacological effects of nystatin.	Nystatin	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	41-46