PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14511273-6	2003	Eletriptan is metabolized primarily by the CYP3A4 enzyme.	eletriptan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49	
16506353-7	2006	Eletriptan is metabolized through the cytochrome P450 3A4 system; therefore, it does have the potential for clinically significant drug interactions.	eletriptan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-57	
12814962-6	2003	The metabolism of ETT to DETT in human liver microsomes was markedly inhibited by troleandomycin, erythromycin, miconazole, and an inhibitory antibody to CYP3A4, but not by inhibitors of other major P450 enzymes.	eletriptan	18-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-160	
12814962-11	2003	ETT metabolism to DETT is therefore catalyzed primarily by CYP3A4, and plasma concentrations are expected to be increased when coadministered with inhibitors of CYP3A4 and P-gp activity.	eletriptan	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65	
12814962-11	2003	ETT metabolism to DETT is therefore catalyzed primarily by CYP3A4, and plasma concentrations are expected to be increased when coadministered with inhibitors of CYP3A4 and P-gp activity.	eletriptan	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	161-167	
10611140-3	2000	Eletriptan was a weak inducer of CYP3A4 protein and cyclosporin A oxidation in four of the six cultures used, whereas rifampicin was a potent inducer in all cultures.	eletriptan	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39	
10611140-5	2000	The amplitude of the increase in CYP3A4 protein and activity by 25 microM eletriptan was significantly lower, with a mean of 19 (P =.0015) and 26% (P =.0002), respectively, of that observed in response to 25 microM rifampicin.	eletriptan	74-84	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39