PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11708926-3 2001 Introduction of nitro and sulfonyl electron-withdrawing groups covalently bound to the P2" guanidine moiety rendered the inhibitors electronically neutral at cellular pH and led to potent inhibition of TNF-alpha release from stimulated macrophages. nitro 16-21 tumor necrosis factor Rattus norvegicus 202-211