PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22794275-1 2012 Tetrahydroquinolines (THQs), a new class of nonsteroidal selective androgen receptor (AR) modulators, have two indispensable functional groups, that is, a hydroxyl group for AR binding and a nitro group for agonistic activity. nitro 191-196 androgen receptor Homo sapiens 86-88 31267866-3 2019 Pharmacophore-based studies revealed that the nitro- or cyano-substituted anilide groups have influenced the activity profiles of non-steroidal AR antagonists, followed by the molecular docking studies with five AR receptors. nitro 46-51 androgen receptor Homo sapiens 144-146 24900588-3 2013 Structure-activity relationship studies confirmed that the pharmacophore of these novel AR antagonists is distinct from the nitro- or cyano-substituted anilide substructure of other nonsteroidal AR antagonists. nitro 124-129 androgen receptor Homo sapiens 88-90 19022677-5 2009 The results suggest that this heterocyclic functionality is potential bioisoster of the nitro and cyano groups forming the polar pharmacophores of known non-steroidal AR ligands. nitro 88-93 androgen receptor Homo sapiens 167-169