PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6491976-7 1984 Metronidazole treatment increased the elimination rate constant for endogenous prothrombin complex activity and decreased the plasma concentration of free R-(+)-warfarin required to decrease prothrombin complex activity synthesis rate to one-half of normal (there were insufficient data to determine the effect of metronidazole on the activity of the other enantiomer). Metronidazole 0-13 coagulation factor II Rattus norvegicus 79-90 6491976-7 1984 Metronidazole treatment increased the elimination rate constant for endogenous prothrombin complex activity and decreased the plasma concentration of free R-(+)-warfarin required to decrease prothrombin complex activity synthesis rate to one-half of normal (there were insufficient data to determine the effect of metronidazole on the activity of the other enantiomer). Metronidazole 0-13 coagulation factor II Rattus norvegicus 191-202