PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18048573-1 2007 Recent case reports suggest that addition of high-dose metronidazole might be associated with elevated plasma concentrations of substrates of cytochrome P450 (CYP) 3A. Metronidazole 55-68 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 142-166 25470432-8 2015 In both cells, the expressions of CYP2C8, CYP2C9, CYP3A4 and constitutive androstane receptor (CAR) were decreased by MTZ treatment. Metronidazole 118-121 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 50-56 11601665-0 2001 Effects of metronidazole on hepatic CYP3A4 activity. Metronidazole 11-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 36-42 17374625-0 2007 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Metronidazole 5-18 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 33-38 17374625-2 2007 OBJECTIVE: To explore whether CYP3A inhibition by metronidazole is the primary mechanism by which metronidazole interacts with coadministered CYP3A substrates. Metronidazole 50-63 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 30-35 17374625-2 2007 OBJECTIVE: To explore whether CYP3A inhibition by metronidazole is the primary mechanism by which metronidazole interacts with coadministered CYP3A substrates. Metronidazole 50-63 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 142-147 17374625-2 2007 OBJECTIVE: To explore whether CYP3A inhibition by metronidazole is the primary mechanism by which metronidazole interacts with coadministered CYP3A substrates. Metronidazole 98-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 30-35 17374625-2 2007 OBJECTIVE: To explore whether CYP3A inhibition by metronidazole is the primary mechanism by which metronidazole interacts with coadministered CYP3A substrates. Metronidazole 98-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 142-147 17374625-8 2007 DATA SYNTHESIS: Elevated plasma concentrations and toxicities have been reported for a number of CYP3A substrates including amiodarone, carbamazepine, quinidine, tacrolimus, and cyclosporine when administered with metronidazole. Metronidazole 214-227 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 97-102 17374625-9 2007 This has led to the widespread belief that metronidazole is a significant inhibitor of CYP3A4. Metronidazole 43-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-93 17374625-11 2007 CONCLUSIONS: Drug interactions between metronidazole and certain CYP3A substrates do not appear to result from CYP3A4/5 inhibition by metronidazole. Metronidazole 39-52 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 65-70 17374625-12 2007 Until any mechanism is identified by which metronidazole alters the disposition of certain CYP3A substrates, drug interactions with this agent should be assessed on a case-by-case basis, taking into account the safety index of the coadministered drug and the availability of equally effective substitutes for either metronidazole or the drug with which it putatively interacts. Metronidazole 43-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 91-96 15855244-8 2005 The possible mechanism may be related to metronidazole"s weak inhibition of CYP3A4 and, possibly, P-glycoprotein. Metronidazole 41-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 76-82 11601665-1 2001 STUDY OBJECTIVE: To evaluate the effect of a short course of oral metronidazole, commonly used for bowel-preparation regimens, on hepatic cytochrome P450 (CYP) 3A4 activity, as measured by the [14C N-methyl]-erythromycin breath test (ERMBT) in healthy volunteers. Metronidazole 66-79 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 138-163 11151744-1 2000 OBJECTIVE: Case reports have described elevated concentrations of CYP3A4 substrates (e.g. cyclosporin) during metronidazole treatment. Metronidazole 110-123 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-72 11151744-2 2000 Therefore, we wanted to study whether metronidazole affects CYP3A4 activity, using midazolam as a model substrate in vitro and in vivo. Metronidazole 38-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 60-66 10917381-8 2000 A contributing factor in this case may have been the concomitant administration of metronidazole, which inhibits the cytochrome P450 enzyme (CYP3A4) also responsible for the metabolism of quetiapine. Metronidazole 83-96 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 141-147