PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30706508-0 2019 Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Metronidazole 11-24 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 42-48 30706508-3 2019 In vitro, CYP2A6 selectively forms 2-hydroxymetronidazole (2HM) from metronidazole (MTZ). Metronidazole 44-57 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 10-16 30706508-3 2019 In vitro, CYP2A6 selectively forms 2-hydroxymetronidazole (2HM) from metronidazole (MTZ). Metronidazole 84-87 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 10-16 30706508-4 2019 The purpose of this study was to evaluate MTZ as a CYP2A6 phenotyping probe drug in healthy adults against the well-established method of measuring trans-3-hydroxycotinine (3HC)/cotinine (COT). Metronidazole 42-45 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 51-57 30706508-10 2019 CYP2A6 genotype had significant impacts on both MTZ and NIC phenotyping ratios with decreased activity predicted phenotypes demonstrating 2HM/MTZ ratios <=58% and 3HC/COT ratios <=56% compared with extensive activity predicted phenotypes at all time points examined in the study (P < 0.05). Metronidazole 48-51 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 30706508-10 2019 CYP2A6 genotype had significant impacts on both MTZ and NIC phenotyping ratios with decreased activity predicted phenotypes demonstrating 2HM/MTZ ratios <=58% and 3HC/COT ratios <=56% compared with extensive activity predicted phenotypes at all time points examined in the study (P < 0.05). Metronidazole 142-145 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 30706508-12 2019 CONCLUSIONS: Metronidazole via 2HM/MTZ performed well as a novel, safe phenotyping probe for CYP2A6 in healthy adults. Metronidazole 13-26 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 93-99 23813797-7 2013 Selective chemical inhibitors of CYP2A6 inhibited metronidazole 2-hydroxylation in a concentration-dependent manner and inhibitory antibodies against CYP2A6 virtually eliminated metronidazole 2-hydroxylation (>99%). Metronidazole 50-63 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 33-39 23813797-7 2013 Selective chemical inhibitors of CYP2A6 inhibited metronidazole 2-hydroxylation in a concentration-dependent manner and inhibitory antibodies against CYP2A6 virtually eliminated metronidazole 2-hydroxylation (>99%). Metronidazole 178-191 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 150-156 23813797-9 2013 These results suggest that CYP2A6 is the primary catalyst responsible for the 2-hydroxylation of metronidazole, a reaction that may function as a marker of CYP2A6 activity both in vitro and in vivo. Metronidazole 97-110 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 27-33 23813797-9 2013 These results suggest that CYP2A6 is the primary catalyst responsible for the 2-hydroxylation of metronidazole, a reaction that may function as a marker of CYP2A6 activity both in vitro and in vivo. Metronidazole 97-110 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 156-162