PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23813797-7	2013	Selective chemical inhibitors of CYP2A6 inhibited metronidazole 2-hydroxylation in a concentration-dependent manner and inhibitory antibodies against CYP2A6 virtually eliminated metronidazole 2-hydroxylation (>99%).	Metronidazole	50-63	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	33-39	
23813797-7	2013	Selective chemical inhibitors of CYP2A6 inhibited metronidazole 2-hydroxylation in a concentration-dependent manner and inhibitory antibodies against CYP2A6 virtually eliminated metronidazole 2-hydroxylation (>99%).	Metronidazole	178-191	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	150-156	
23813797-9	2013	These results suggest that CYP2A6 is the primary catalyst responsible for the 2-hydroxylation of metronidazole, a reaction that may function as a marker of CYP2A6 activity both in vitro and in vivo.	Metronidazole	97-110	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	27-33	
23813797-9	2013	These results suggest that CYP2A6 is the primary catalyst responsible for the 2-hydroxylation of metronidazole, a reaction that may function as a marker of CYP2A6 activity both in vitro and in vivo.	Metronidazole	97-110	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	156-162	
30706508-0	2019	Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.	Metronidazole	11-24	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	42-48	
30706508-3	2019	In vitro, CYP2A6 selectively forms 2-hydroxymetronidazole (2HM) from metronidazole (MTZ).	Metronidazole	44-57	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	10-16	
30706508-3	2019	In vitro, CYP2A6 selectively forms 2-hydroxymetronidazole (2HM) from metronidazole (MTZ).	Metronidazole	84-87	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	10-16	
30706508-4	2019	The purpose of this study was to evaluate MTZ as a CYP2A6 phenotyping probe drug in healthy adults against the well-established method of measuring trans-3-hydroxycotinine (3HC)/cotinine (COT).	Metronidazole	42-45	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	51-57	
30706508-10	2019	CYP2A6 genotype had significant impacts on both MTZ and NIC phenotyping ratios with decreased activity predicted phenotypes demonstrating 2HM/MTZ ratios <=58% and 3HC/COT ratios <=56% compared with extensive activity predicted phenotypes at all time points examined in the study (P < 0.05).	Metronidazole	48-51	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6	
30706508-10	2019	CYP2A6 genotype had significant impacts on both MTZ and NIC phenotyping ratios with decreased activity predicted phenotypes demonstrating 2HM/MTZ ratios <=58% and 3HC/COT ratios <=56% compared with extensive activity predicted phenotypes at all time points examined in the study (P < 0.05).	Metronidazole	142-145	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6	
30706508-12	2019	CONCLUSIONS: Metronidazole via 2HM/MTZ performed well as a novel, safe phenotyping probe for CYP2A6 in healthy adults.	Metronidazole	13-26	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	93-99