PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31165701-0	2019	Nanoparticulate TiO2 Induced Suppression of Spermatogenesis is Involved in Regulatory Dysfunction of the cAMP-CREB/CREM Signaling Pathway in Mice.	titanium dioxide	16-20	cAMP responsive element binding protein 1	Mus musculus	110-114	
31165701-5	2019	Furthermore, nano-TiO2 also induced significant reductions in protein expression including cyclic adenosine monophosphate content, protein kinase A, cAMP-responsive element modulator, p-cAMP-response element binding protein, lactate dehydrogenase-C, testis-specific protein kinase 1, and testicular specific CREM activator, and upregulation of protein expression including protein phosphatase, and transducer of regulated CREB 1, which may be associated with reductions of follicle stimulating hormone and luteinizing hormone levels.	titanium dioxide	18-22	cAMP responsive element binding protein 1	Mus musculus	422-428	
31165701-6	2019	Together, the present study indicates that the reductions of FSH and LH concentrations and suppression of spermatogenesis in mice caused by nano-TiO2 may be associated with the dysfunctions of the cAMP-CREB/CREM signaling pathway.	titanium dioxide	145-149	cAMP responsive element binding protein 1	Mus musculus	202-206	
24295774-5	2014	We observed that subchronic peroral exposure to TiO2 NPs caused severe pathological changes, spatial recognition impairment, and resulted in significant LTP reduction and down-regulation of N-methyl-D-aspartate (NMDA) receptor subunits (NR2A and NR2B) expression associated with the simultaneous inhibition of CaMKIV, cyclic-AMP responsive element binding proteins (CREB-1, CREB-2), and FosB/DFosB in mouse hippocampal tissues.	titanium dioxide	48-52	cAMP responsive element binding protein 1	Mus musculus	366-372