PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31649848-4	2019	Our results indicated that imipenem and cilastatin were substrates of hOAT1 and hOAT3.	Imipenem	27-35	solute carrier family 22 member 6	Homo sapiens	70-75	
32373203-3	2020	At the same time, imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1 (hOAT1)-HEK293 and human OAT3 (hOAT3)-HEK293 cells.	Imipenem	18-26	solute carrier family 22 member 6	Homo sapiens	110-114	
32373203-3	2020	At the same time, imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1 (hOAT1)-HEK293 and human OAT3 (hOAT3)-HEK293 cells.	Imipenem	18-26	solute carrier family 22 member 6	Homo sapiens	116-121	
32373203-5	2020	The uptakes of imipenem and cilastatin in hOAT1- and hOAT3-HEK 293 cells were significantly higher than that in mock-HEK-293 cells.	Imipenem	15-23	solute carrier family 22 member 6	Homo sapiens	42-47	
31649848-5	2019	Cilastatin inhibited hOAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug-drug interaction (DDI).	Imipenem	51-59	solute carrier family 22 member 6	Homo sapiens	21-26	
31649848-6	2019	Moreover, imipenem exhibited hOAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid.	Imipenem	10-18	solute carrier family 22 member 6	Homo sapiens	29-34