PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3884565-3 1985 When an E. coli strain producing high levels of TEM-1 beta-lactamase constituted 6% or more of the population, the whole colony was resistant to cefamandole, but still sensitive to cefotaxime, cefoxitin or imipenem. Imipenem 206-214 TEM-1 beta-lactamase Escherichia coli 48-68 10223937-9 1999 However, measurement of beta-lactamase activities (including measurements under conditions where TEM-1 beta-lactamase was inhibited) indicated that the imipenem-intermediate isolate expressed six- to eightfold less beta-lactamase than did the other isolates. Imipenem 152-160 TEM-1 beta-lactamase Escherichia coli 97-117