PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32196336-2 2020 The combinations imipenem/3 and imipenem/4 restored almost completely the antibiotic efficacy in OXA-23 and OXA-24/40 carbapenemase-producing A. baumannii strains (1 microg mL-1), and also provided good results for OXA-48 carbapenemase-producing K. pneumoniae strains (4 microg mL-1). Imipenem 17-25 class D beta-lactamase OXA-23 Acinetobacter baumannii 97-103 33227138-1 2021 OBJECTIVES: To evaluate the in vivo efficacy of a dual carbapenem combination containing imipenem plus meropenem against carbapenem-resistant Acinetobacter baumannii producing carbapenemases OXA-23 or OXA-58. Imipenem 89-97 class D beta-lactamase OXA-23 Acinetobacter baumannii 191-197 33227138-7 2021 In blood, the carbapenem combination significantly decreased the bacterial load of the OXA-23 producers compared with imipenem or meropenem used in monotherapy. Imipenem 118-126 class D beta-lactamase OXA-23 Acinetobacter baumannii 87-93 33057603-2 2021 OBJECTIVES: In the present study, the in vitro and in vivo activities of imipenem combined with BLI-489 against CRAb producing carbapenem-hydrolysing class D beta-lactamases (CHDLs), namely OXA-23, OXA-24, OXA-51 and OXA-58, were determined. Imipenem 73-81 class D beta-lactamase OXA-23 Acinetobacter baumannii 190-196 33057603-7 2021 RESULTS: Chequerboard analysis showed that imipenem and BLI-489 had a synergistic effect on 14.3, 92.9, 100, 16.7 and 100% of MBL-, OXA-23-, OXA-24-like-, OXA-51-like- and OXA-58-producing CRAb isolates, respectively. Imipenem 43-51 class D beta-lactamase OXA-23 Acinetobacter baumannii 132-138 32196336-2 2020 The combinations imipenem/3 and imipenem/4 restored almost completely the antibiotic efficacy in OXA-23 and OXA-24/40 carbapenemase-producing A. baumannii strains (1 microg mL-1), and also provided good results for OXA-48 carbapenemase-producing K. pneumoniae strains (4 microg mL-1). Imipenem 32-40 class D beta-lactamase OXA-23 Acinetobacter baumannii 97-103 30530607-2 2019 We investigated the role of the conserved hydrophobic bridge in the carbapenemase activity of OXA-23, the major carbapenemase of the important pathogen Acinetobacter baumannii We show that substitution of the bridge residue Phe110 affects resistance to meropenem and doripenem and has little effect on MICs of imipenem. Imipenem 310-318 class D beta-lactamase OXA-23 Acinetobacter baumannii 94-100 28855926-0 2016 Role of Aders and OXA23 Genes among Imipenem Resistant Acinetobacter baumannii Isolates from Two Hospitals of Tehran, Iran. Imipenem 36-44 class D beta-lactamase OXA-23 Acinetobacter baumannii 18-23 28855926-1 2016 BACKGROUND: This study aimed to evaluate the role of efflux pump regulator and OXA-23 genes in imipenem resistance Acinetobacter baumannii strains isolated from hospitalized patients in Tehran, Iran. Imipenem 95-103 class D beta-lactamase OXA-23 Acinetobacter baumannii 79-85 26004171-0 2015 Spread of imipenem-resistant Acinetobacter baumannii co-expressing OXA-23 and GES-11 carbapenemases in Lebanon. Imipenem 10-18 class D beta-lactamase OXA-23 Acinetobacter baumannii 67-73 25648393-14 2015 Imipenem/meropenem/rifampicin in combination with polymyxin B demonstrated consistent bactericidal effect against 49 bla OXA-23-harbouring XDR A. baumannii clinical isolates, suggesting a role of combination therapy in the treatment of these infections. Imipenem 0-8 class D beta-lactamase OXA-23 Acinetobacter baumannii 121-127 24675065-5 2015 RESULTS: Fifteen out of 59 isolates expressing imipenem-resistant A. baumannii clinical isolates acquired either a bla(OxA-23) beta-lactamase gene. Imipenem 47-55 class D beta-lactamase OXA-23 Acinetobacter baumannii 119-125 22581767-8 2013 We also found four imipenem resistant isolates carrying OXA-23 gene without showing carbapenemase phenotype. Imipenem 19-27 class D beta-lactamase OXA-23 Acinetobacter baumannii 56-62 22352411-7 2012 Among imipenem resistant isolates, 88.7% carried bla(OXA-23)-like, 1.6% carried bla(OXA-40)-like, and 3.2% had bla(OXA-58)-like resistance genes. Imipenem 6-14 class D beta-lactamase OXA-23 Acinetobacter baumannii 53-59 24031953-0 2012 Imipenem-resistant Acinetobacter baumannii carrying the ISAba1-bla OXA-23,51 and ISAba1-bla ADC-7 genes in Monteria, Colombia. Imipenem 0-8 class D beta-lactamase OXA-23 Acinetobacter baumannii 67-73 22352411-8 2012 Ninety percent of isolates contained ISAba1 element and in 74.2% of imipenem resistant isolates, ISAba1 was located in upstream of bla(OXA-23)-like. Imipenem 68-76 class D beta-lactamase OXA-23 Acinetobacter baumannii 135-141 21586593-10 2011 CONCLUSIONS: Imipenem-resistant global clone 2 A. baumannii isolates containing bla(OXA-23) have been present in Australian hospitals for at least 10 years. Imipenem 13-21 class D beta-lactamase OXA-23 Acinetobacter baumannii 84-90 21871784-7 2011 In multivariate logistic regression, the presence of bla(OXA-23) and bla(TEM-1) had a statistically significant association with imipenem resistance [bla(OXA-23), P=0.004, odds ratio (OR)=10.52, 95% confidence interval (CI) 2.12-52.17; bla(TEM-1), P=0.005, OR=6.14, 95% CI 1.74-21.62]. Imipenem 129-137 class D beta-lactamase OXA-23 Acinetobacter baumannii 57-63 21871784-7 2011 In multivariate logistic regression, the presence of bla(OXA-23) and bla(TEM-1) had a statistically significant association with imipenem resistance [bla(OXA-23), P=0.004, odds ratio (OR)=10.52, 95% confidence interval (CI) 2.12-52.17; bla(TEM-1), P=0.005, OR=6.14, 95% CI 1.74-21.62]. Imipenem 129-137 class D beta-lactamase OXA-23 Acinetobacter baumannii 154-160 21871784-8 2011 These results suggest that detecting bla(OXA-23) and bla(TEM-1) genes could be used to predict imipenem resistance in MDR-AB isolates. Imipenem 95-103 class D beta-lactamase OXA-23 Acinetobacter baumannii 41-47 21656808-19 2011 This study also shows a high distribution of bla(OXA-23) -like and intI1 genes in imipenem-resistant A. baumannii isolates. Imipenem 82-90 class D beta-lactamase OXA-23 Acinetobacter baumannii 49-55 20351457-5 2010 RESULTS: The mechanism responsible for the resistance to imipenem was the production of OXA-23 and OXA-58 carbapenemases. Imipenem 57-65 class D beta-lactamase OXA-23 Acinetobacter baumannii 88-94 18216212-3 2008 Analysis of carbapenemases by PCR revealed that imipenem resistance but not meropenem resistance was associated with the presence of bla(OXA-23) and bla(OXA-40) genes. Imipenem 48-56 class D beta-lactamase OXA-23 Acinetobacter baumannii 137-143 19589905-3 2009 The outbreak strain was resistant to penicillins, cephalosporins, ciprofloxacin, gentamicin, tobramycin, imipenem and meropenem, and carried the bla(OXA-23)-like gene. Imipenem 105-113 class D beta-lactamase OXA-23 Acinetobacter baumannii 149-155 18725452-6 2008 The presence of the carbapenemase gene bla(OXA-23) and the 16S rRNA methylase gene armA predicted high-level resistance to imipenem and amikacin, respectively. Imipenem 123-131 class D beta-lactamase OXA-23 Acinetobacter baumannii 43-49 19531268-7 2009 The presence of bla(OXA-23) in 13% (11/83) and IS(Aba1) linked bla(OXA-66) in 79.5% (66/83) of clinical isolates was associated with high level imipenem resistance. Imipenem 144-152 class D beta-lactamase OXA-23 Acinetobacter baumannii 20-26 19531268-9 2009 CONCLUSION: This study underscores the major role of carbapenem-hydrolyzing class D beta-lactamases, and in particular the acquired OXA-23, in the dissemination of imipenem-resistant A. baumannii. Imipenem 164-172 class D beta-lactamase OXA-23 Acinetobacter baumannii 132-138 17339277-8 2007 Imipenem-resistant Acinetobacter genomic species 13TU isolates produced VIM-2 metallo-beta-lactamase, while imipenem-resistant A. baumannii isolates produced OXA-23 and/or OXA-51 beta-lactamase. Imipenem 0-8 class D beta-lactamase OXA-23 Acinetobacter baumannii 158-164 17644715-0 2007 Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital. Imipenem 17-25 class D beta-lactamase OXA-23 Acinetobacter baumannii 81-97 17339277-8 2007 Imipenem-resistant Acinetobacter genomic species 13TU isolates produced VIM-2 metallo-beta-lactamase, while imipenem-resistant A. baumannii isolates produced OXA-23 and/or OXA-51 beta-lactamase. Imipenem 108-116 class D beta-lactamase OXA-23 Acinetobacter baumannii 158-164 35420470-6 2022 The antimicrobial susceptibility studies presented here demonstrated that this compound is more potent than meropenem and imipenem against A. baumannii producing OXA-23, the most prevalent CHDL of this pathogen, and also against strains producing the CHDL OXA-24/40 and the class B metallo-beta-lactamase VIM-2. Imipenem 122-130 class D beta-lactamase OXA-23 Acinetobacter baumannii 162-168