PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27469416-8	2017	A total of 121 isolates were resistant to imipenem, of which 104 (86%) produced carbapenemases: 74 OXA-48, 14 VIM, 9 KPC (6 KPC-2 and 3 KPC-3), 6 IMP, and 1 GES.	Imipenem	42-50	KPC-3	Klebsiella pneumoniae	136-141	
35311523-4	2022	Using timed mass spectrometry, the D179Y variant formed prolonged acyl-enzyme complexes with imipenem (IMI) and meropenem (MEM) in KPC-2 and KPC-3, which could be detected up to 24 h, suggesting that IMI and MEM act as covalent beta-lactamase inhibitors more than as substrates for D179Y KPC-2 and -3.	Imipenem	93-101	KPC-3	Klebsiella pneumoniae	141-146	
35311523-4	2022	Using timed mass spectrometry, the D179Y variant formed prolonged acyl-enzyme complexes with imipenem (IMI) and meropenem (MEM) in KPC-2 and KPC-3, which could be detected up to 24 h, suggesting that IMI and MEM act as covalent beta-lactamase inhibitors more than as substrates for D179Y KPC-2 and -3.	Imipenem	103-106	KPC-3	Klebsiella pneumoniae	141-146	
30632921-5	2019	Secretion of KPC-2 and its variant KPC-3 by the K. pneumoniae strains causes resistance to both the substrate imipenem and the beta-lactamase inhibitors.	Imipenem	110-118	KPC-3	Klebsiella pneumoniae	35-40	
26571390-7	2016	The clinical (biochemical test) and molecular (multiplex-PCR and rpoB gene) characterization identified imipenem resistance in the first six K. pneumoniae ST258 isolates, which encode the SHV-12 cephalosporinase and KPC-3 carbapenemase genes.	Imipenem	104-112	KPC-3	Klebsiella pneumoniae	216-221