PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14693513-3	2004	The beta-lactamase OXA-48 hydrolyzed imipenem at a high level and was remotely related (less than 46% amino acid identity) to the other oxacillinases.	Imipenem	37-45	OXA-48	Klebsiella pneumoniae	19-25	
25653401-2	2015	In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loaded with the tested strain and impregnated with EDTA and EDTA plus phenyl boronic acid (PBA), respectively.	Imipenem	94-102	OXA-48	Klebsiella pneumoniae	55-61	
25653401-2	2015	In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loaded with the tested strain and impregnated with EDTA and EDTA plus phenyl boronic acid (PBA), respectively.	Imipenem	144-152	OXA-48	Klebsiella pneumoniae	55-61	
24626209-10	2014	Minimum inhibitory concentrations (MICs) of KP(OXA-48) and E. coli(OXA-48) for imipenem and meropenem ranged from <=1 to >=16 mg/L, and 153/157 (97%) had MIC >0.25 mg/L for ertapenem.	Imipenem	79-87	OXA-48	Klebsiella pneumoniae	44-53	
24626209-10	2014	Minimum inhibitory concentrations (MICs) of KP(OXA-48) and E. coli(OXA-48) for imipenem and meropenem ranged from <=1 to >=16 mg/L, and 153/157 (97%) had MIC >0.25 mg/L for ertapenem.	Imipenem	79-87	OXA-48	Klebsiella pneumoniae	47-53	
22041508-5	2012	Klebsiella pneumoniae isolates with OXA-48 beta-lactamase were resistant to imipenem [MIC for 90% of the organisms (MIC(90)) >=4 mg/L].	Imipenem	76-84	OXA-48	Klebsiella pneumoniae	36-42	
22041508-8	2012	In conclusion, combinations of imipenem, cefepime and ceftazidime with avibactam may present a promising therapeutic strategy to treat infections due to K. pneumoniae with OXA-48 enzyme as well as K. pneumoniae and E. coli with CTX-M-15 enzyme.	Imipenem	31-39	OXA-48	Klebsiella pneumoniae	172-178	
23034714-7	2013	RESULTS: All 21 isolates had ertapenem MICs >= 1 mg/L, but 47.6% remained susceptible to imipenem and meropenem; bla(OXA-48) was identified in 19 isolates (90.5%) and the novel bla(OXA-244) and bla(OXA-245) genes were detected in 1 isolate each.	Imipenem	92-100	OXA-48	Klebsiella pneumoniae	120-126	
34202402-5	2021	Importantly, the most potent representative of the latter series (ID2, AC50 = 0.99 muM) inhibited OXA-48 via a reversible and competitive mechanism of action, as demonstrated by biochemical and X-ray studies; furthermore, it slightly improved imipenem"s activity in Escherichia coli ATCC BAA-2523 beta-lactam resistant strain.	Imipenem	243-251	OXA-48	Klebsiella pneumoniae	98-104	
34422689-9	2021	The majority of OXA-48 producing isolates were resistant to ertapenem but susceptible to imipenem and meropenem.	Imipenem	89-97	OXA-48	Klebsiella pneumoniae	16-22	
35066144-8	2022	Amongst the 93 P. aeruginosa isolates under evaluation, relebactam (4 mg/L) addition resulted in a 4-to-16-fold reduction in the MICs of IPM in all 15 IPM-NS-P. aeruginosa isolates (including 10 porin-deficient ones) not harbouring blaMBL/blaOXA-48-like genes.	Imipenem	137-140	OXA-48	Klebsiella pneumoniae	239-248	
33945553-12	2021	Two of the CTX-M-15 producing isolates carried a carbapenemase gene (blaKPC2/3 and blaOXA-48) and showed imipenem resistance.	Imipenem	105-113	OXA-48	Klebsiella pneumoniae	83-92	
33299744-10	2020	bla KPC was detected in 12 (54.55%) of the strains, and 4 of them which had an MIC> 16 mug/mL to imipenem showed bla OXA-48 positivity as well.	Imipenem	97-105	OXA-48	Klebsiella pneumoniae	117-123