PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33299744-10 2020 bla KPC was detected in 12 (54.55%) of the strains, and 4 of them which had an MIC> 16 mug/mL to imipenem showed bla OXA-48 positivity as well. Imipenem 97-105 OXA-48 Klebsiella pneumoniae 117-123 34202402-5 2021 Importantly, the most potent representative of the latter series (ID2, AC50 = 0.99 muM) inhibited OXA-48 via a reversible and competitive mechanism of action, as demonstrated by biochemical and X-ray studies; furthermore, it slightly improved imipenem"s activity in Escherichia coli ATCC BAA-2523 beta-lactam resistant strain. Imipenem 243-251 OXA-48 Klebsiella pneumoniae 98-104 33945553-12 2021 Two of the CTX-M-15 producing isolates carried a carbapenemase gene (blaKPC2/3 and blaOXA-48) and showed imipenem resistance. Imipenem 105-113 OXA-48 Klebsiella pneumoniae 83-92 34422689-9 2021 The majority of OXA-48 producing isolates were resistant to ertapenem but susceptible to imipenem and meropenem. Imipenem 89-97 OXA-48 Klebsiella pneumoniae 16-22 35066144-8 2022 Amongst the 93 P. aeruginosa isolates under evaluation, relebactam (4 mg/L) addition resulted in a 4-to-16-fold reduction in the MICs of IPM in all 15 IPM-NS-P. aeruginosa isolates (including 10 porin-deficient ones) not harbouring blaMBL/blaOXA-48-like genes. Imipenem 137-140 OXA-48 Klebsiella pneumoniae 239-248 23034714-7 2013 RESULTS: All 21 isolates had ertapenem MICs >= 1 mg/L, but 47.6% remained susceptible to imipenem and meropenem; bla(OXA-48) was identified in 19 isolates (90.5%) and the novel bla(OXA-244) and bla(OXA-245) genes were detected in 1 isolate each. Imipenem 92-100 OXA-48 Klebsiella pneumoniae 120-126 22041508-5 2012 Klebsiella pneumoniae isolates with OXA-48 beta-lactamase were resistant to imipenem [MIC for 90% of the organisms (MIC(90)) >=4 mg/L]. Imipenem 76-84 OXA-48 Klebsiella pneumoniae 36-42 22041508-8 2012 In conclusion, combinations of imipenem, cefepime and ceftazidime with avibactam may present a promising therapeutic strategy to treat infections due to K. pneumoniae with OXA-48 enzyme as well as K. pneumoniae and E. coli with CTX-M-15 enzyme. Imipenem 31-39 OXA-48 Klebsiella pneumoniae 172-178 25653401-2 2015 In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loaded with the tested strain and impregnated with EDTA and EDTA plus phenyl boronic acid (PBA), respectively. Imipenem 94-102 OXA-48 Klebsiella pneumoniae 55-61 25653401-2 2015 In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loaded with the tested strain and impregnated with EDTA and EDTA plus phenyl boronic acid (PBA), respectively. Imipenem 144-152 OXA-48 Klebsiella pneumoniae 55-61 24626209-10 2014 Minimum inhibitory concentrations (MICs) of KP(OXA-48) and E. coli(OXA-48) for imipenem and meropenem ranged from <=1 to >=16 mg/L, and 153/157 (97%) had MIC >0.25 mg/L for ertapenem. Imipenem 79-87 OXA-48 Klebsiella pneumoniae 44-53 24626209-10 2014 Minimum inhibitory concentrations (MICs) of KP(OXA-48) and E. coli(OXA-48) for imipenem and meropenem ranged from <=1 to >=16 mg/L, and 153/157 (97%) had MIC >0.25 mg/L for ertapenem. Imipenem 79-87 OXA-48 Klebsiella pneumoniae 47-53 14693513-3 2004 The beta-lactamase OXA-48 hydrolyzed imipenem at a high level and was remotely related (less than 46% amino acid identity) to the other oxacillinases. Imipenem 37-45 OXA-48 Klebsiella pneumoniae 19-25