PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1967149-1 1990 We have previously shown that 131I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1+) AKR/J SL2 T cell lymphoma nodules in AKR/Cum (Thy1.2+) mice. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 77-83 1967149-1 1990 We have previously shown that 131I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1+) AKR/J SL2 T cell lymphoma nodules in AKR/Cum (Thy1.2+) mice. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 137-143 1967149-1 1990 We have previously shown that 131I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1+) AKR/J SL2 T cell lymphoma nodules in AKR/Cum (Thy1.2+) mice. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 137-143 1967149-1 1990 We have previously shown that 131I-labeled monoclonal antibodies against the Thy1.1 differentiation antigen can induce the regression of Thy1.1 antigen-positive (Thy1.1+) AKR/J SL2 T cell lymphoma nodules in AKR/Cum (Thy1.2+) mice. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 217-223 1967149-2 1990 In this study, we examined the ability of 131I-labeled anti-Thy1.1 antibodies to eliminate tumor nodules containing variant lymphoma cells that do not express the Thy1.1 antigen (Thy1.1-). Iodine-131 42-46 thymus cell antigen 1, theta Mus musculus 60-66 1967149-4 1990 One week later, when an established tumor nodule was present, mice were treated with 1,500-1,700 microCi of 131I-labeled anti-Thy1.1 antibody. Iodine-131 108-112 thymus cell antigen 1, theta Mus musculus 126-132 1967149-6 1990 In contrast, no complete regressions were observed in mice with only antigen-negative tumor cells treated with 131I-labeled anti-Thy1.1 antibody or in mice inoculated with antigen-positive tumor and treated with an 131I-labeled control antibody. Iodine-131 111-115 thymus cell antigen 1, theta Mus musculus 129-135 3779642-1 1986 We have shown previously that 131I-labeled antibodies against the Thy-1.1 differentiation antigen can cure AKR/Cum (Thy-1.2+) mice bearing AKR/J (Thy-1.1+) SL2 T-cell lymphoma. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 66-73 3501420-2 1987 In our studies of the 131I-labeled anti-Thy 1.1 antibody treatment of murine lymphoma we have used cell binding assays with a combination of Lineweaver-Burk analysis to determine immunoreactivity and Scatchard analysis to determine antibody avidity. Iodine-131 22-26 thymus cell antigen 1, theta Mus musculus 40-47 3501420-4 1987 For 131I-labeled anti-Thy 1.1 antibody, avidity was a much more sensitive indicator of iodination damage and predictor of in vivo behavior than was immunoreactivity, while for other antibodies immunoreactivity has been a better indicator of labeling damage. Iodine-131 4-8 thymus cell antigen 1, theta Mus musculus 22-29 3779642-1 1986 We have shown previously that 131I-labeled antibodies against the Thy-1.1 differentiation antigen can cure AKR/Cum (Thy-1.2+) mice bearing AKR/J (Thy-1.1+) SL2 T-cell lymphoma. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 116-123 3779642-1 1986 We have shown previously that 131I-labeled antibodies against the Thy-1.1 differentiation antigen can cure AKR/Cum (Thy-1.2+) mice bearing AKR/J (Thy-1.1+) SL2 T-cell lymphoma. Iodine-131 30-34 thymus cell antigen 1, theta Mus musculus 146-153 3779642-2 1986 In the present study we have extended these studies to the therapy of SL2 lymphoma in AKR/J mice, where 131I-anti-labeled Thy-1.1 antibodies react with both tumor and normal T-lymphocytes. Iodine-131 104-108 thymus cell antigen 1, theta Mus musculus 122-129 3779642-3 1986 A single 25-micrograms bolus of 131I-labeled anti-Thy-1.1 antibody was rapidly cleared from serum by binding to spleen cells (t1/2 less than 3 h) and only low concentrations (less than 2% injected dose/g) were present in tumor 24 h after infusion. Iodine-131 32-36 thymus cell antigen 1, theta Mus musculus 50-57 3779642-7 1986 Therapy of AKR/J mice bearing established s.c. lymphoma nodules with 1,500 mu Ci of 131I-anti-Thy-1.1 antibody given in this latter regimen resulted in complete regression of the nodule in 70% of animals and had a greater antitumor effect (27% complete regression, P less than 0.001) than 750 mu Ci of 131I-labeled irrelevant antibody, a dose that would deliver equivalent radiation to normal organs (liver, kidney, and lung). Iodine-131 84-88 thymus cell antigen 1, theta Mus musculus 94-101 3779642-7 1986 Therapy of AKR/J mice bearing established s.c. lymphoma nodules with 1,500 mu Ci of 131I-anti-Thy-1.1 antibody given in this latter regimen resulted in complete regression of the nodule in 70% of animals and had a greater antitumor effect (27% complete regression, P less than 0.001) than 750 mu Ci of 131I-labeled irrelevant antibody, a dose that would deliver equivalent radiation to normal organs (liver, kidney, and lung). Iodine-131 302-306 thymus cell antigen 1, theta Mus musculus 94-101 3978621-0 1985 Experimental radiotherapy of murine lymphoma with 131I-labeled anti-Thy 1.1 monoclonal antibody. Iodine-131 50-54 thymus cell antigen 1, theta Mus musculus 68-75 3978621-2 1985 To overcome this limitation, we have evaluated the use of 131I-labeled anti-Thy 1.1 antibodies for the therapy of established AKR/J SL2 lymphoma (Thy 1.1+) nodules growing in congeneic AKR/Cu mice (Thy 1.2+). Iodine-131 58-62 thymus cell antigen 1, theta Mus musculus 76-83 3978621-2 1985 To overcome this limitation, we have evaluated the use of 131I-labeled anti-Thy 1.1 antibodies for the therapy of established AKR/J SL2 lymphoma (Thy 1.1+) nodules growing in congeneic AKR/Cu mice (Thy 1.2+). Iodine-131 58-62 thymus cell antigen 1, theta Mus musculus 146-153 3978621-3 1985 In these experiments, 131I-anti-Thy 1.1 antibody specifically localized to a s.c. tumor with a mean of 6.5% of the infused dose per g of tumor at 24 h after infusion. Iodine-131 22-26 thymus cell antigen 1, theta Mus musculus 32-39 3978621-6 1985 The concentrations of 131I-anti-Thy 1.1 in tumor would result in delivery of a mean of 1600 cGy to tumor following infusion of 500 muCi of 131I-labeled anti-Thy 1.1 antibody. Iodine-131 22-26 thymus cell antigen 1, theta Mus musculus 32-39 3978621-6 1985 The concentrations of 131I-anti-Thy 1.1 in tumor would result in delivery of a mean of 1600 cGy to tumor following infusion of 500 muCi of 131I-labeled anti-Thy 1.1 antibody. Iodine-131 22-26 thymus cell antigen 1, theta Mus musculus 157-164 3978621-6 1985 The concentrations of 131I-anti-Thy 1.1 in tumor would result in delivery of a mean of 1600 cGy to tumor following infusion of 500 muCi of 131I-labeled anti-Thy 1.1 antibody. Iodine-131 139-143 thymus cell antigen 1, theta Mus musculus 32-39 3978621-6 1985 The concentrations of 131I-anti-Thy 1.1 in tumor would result in delivery of a mean of 1600 cGy to tumor following infusion of 500 muCi of 131I-labeled anti-Thy 1.1 antibody. Iodine-131 139-143 thymus cell antigen 1, theta Mus musculus 157-164