PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32482757-4	2020	All other CYP isoforms tested did not show evidence for TDI, but potent inhibition of CYP2B6 (IC50 = 1.5 microM) was observed following a 30-minute pre-incubation both in the absence and presence of NADPH, an unexpected observation given the fact that no CYP2B6 inhibition was observed in the direct reversible inhibition assay up to 10 microM of PBD.	1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)	347-350	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	86-92	
32482757-5	2020	No other CYP isoforms were susceptible to this apparent non-NADPH dependent inhibition, suggesting that PBD may selectively inactivate CYP2B6 without metabolic activation.	1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)	104-107	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	135-141	
32482757-6	2020	The washing of the HLM pellet after 45 min incubation with PBD did not fully recover the CYP2B6 activity, indicating that PBD is covalently binding to CYP2B6 leading to inactivation of the enzyme.	1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)	122-125	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	151-157