PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19478146-5 2009 RESEARCH DESIGN AND METHODS: Palmitate-induced gene expression was studied in primary human myotubes of 39 metabolically characterized individuals, as well as in an SCD1-overexpressing cell culture model. Palmitates 29-38 stearoyl-CoA desaturase Homo sapiens 165-169 25943877-8 2015 Supplementation with the SCD1 enzymatic product, oleate, rescued AML and e-BL cells from BaP cell killing and decreased levels of BaP-induced reactive oxygen species, whereas supplementation with the SCD1 substrate (and FASN product), palmitate, did not rescue cells. Palmitates 235-244 stearoyl-CoA desaturase Homo sapiens 25-29 19478146-4 2009 Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate. Palmitates 99-108 stearoyl-CoA desaturase Homo sapiens 80-84 19478146-4 2009 Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate. Palmitates 178-187 stearoyl-CoA desaturase Homo sapiens 80-84 29597210-6 2018 Palmitate induced lipid accumulation and mRNA expression of lipogenic genes such as SREBP1c and SCD1. Palmitates 0-9 stearoyl-CoA desaturase Homo sapiens 96-100 26481476-5 2016 Given this, we hypothesized that the influence of PA, SA, PMA and OA on inflammation and cellular stress, as well as FA metabolism, would be exacerbated with reduced SCD1 activity. Palmitates 50-52 stearoyl-CoA desaturase Homo sapiens 166-170 26481476-9 2016 The proinflammatory effects observed with SA are particularly notable given that SCD1-inhibited adipocytes increased elongation of PA to SA, as determined using U-(13)C-PA. Palmitates 131-133 stearoyl-CoA desaturase Homo sapiens 81-85 26481476-10 2016 The effects of PA, PMA and OA were not as substantial as those of SA, although PA did significantly increase Ccl5 (2.7-fold) and Mcp-1 (1.2-fold) expression in SCD1-inhibited adipocytes. Palmitates 79-81 stearoyl-CoA desaturase Homo sapiens 160-164 25660172-2 2015 The effects of cod liver oil supplementation on SCD activity, as estimated by the palmitoleate/palmitate ratio, depended on the docosahexaenoic acid (DHA) contents at baseline. Palmitates 95-104 stearoyl-CoA desaturase Homo sapiens 48-51 24055053-5 2013 Treatment of cells with SCD inhibitors blocked incorporation of palmitate analogs into Wnt3a and Wnt5a and reduced Wnt secretion as well as autocrine and paracrine Wnt signaling. Palmitates 64-73 stearoyl-CoA desaturase Homo sapiens 24-27 23376425-7 2013 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated with aberrant palmitate signaling in aggressive HCC samples. Palmitates 90-99 stearoyl-CoA desaturase Homo sapiens 21-44 23376425-7 2013 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated with aberrant palmitate signaling in aggressive HCC samples. Palmitates 90-99 stearoyl-CoA desaturase Homo sapiens 46-49 20032470-0 2010 De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. Palmitates 118-127 stearoyl-CoA desaturase Homo sapiens 24-47 19478146-6 2009 RESULTS: SCD1 mRNA expression and inducibility by palmitate in cultured myotubes showed a broad interindividual variation, presumably due to inheritable characteristics of the donors. Palmitates 50-59 stearoyl-CoA desaturase Homo sapiens 9-13 19478146-8 2009 In primary human myotubes, high SCD1 inducibility was associated with a low inflammatory (interleukin [IL]-6, IL-8, and chemokine [CXC motif] ligand 3 [CXCL3]) and ER stress (CCAAT/enhancer binding protein [C/EBP] homologous protein, activating transcription factor 3 [ATF3], and X-box binding protein 1 [XBP1]) response to palmitate exposure. Palmitates 324-333 stearoyl-CoA desaturase Homo sapiens 32-36 19478146-9 2009 Finally, palmitate-stimulated SCD1 mRNA expression, positively correlated with intramyocellular lipid (IMCL) content of the donors, was measured by (1)H-magnetic resonance spectroscopy. Palmitates 9-18 stearoyl-CoA desaturase Homo sapiens 30-34 19478146-11 2009 CONCLUSIONS: We hypothesize that myocellular SCD1 inducibility by palmitate is an individual characteristic that modulates lipid storage, palmitate-induced inflammation, ER stress, and insulin resistance. Palmitates 66-75 stearoyl-CoA desaturase Homo sapiens 45-49 19478146-11 2009 CONCLUSIONS: We hypothesize that myocellular SCD1 inducibility by palmitate is an individual characteristic that modulates lipid storage, palmitate-induced inflammation, ER stress, and insulin resistance. Palmitates 138-147 stearoyl-CoA desaturase Homo sapiens 45-49 14967823-7 2004 This was associated with increased palmitate and stearate desaturation by stearoyl-CoA desaturase (SCD), another gene product induced by LXR/RXR ligands. Palmitates 35-44 stearoyl-CoA desaturase Homo sapiens 99-102 18523127-6 2008 Following that, we could show that upregulation of hSCD-1 using the LXR activator TO-901317 in HAECs protects the cells against palmitate-induced lipotoxicity, cell apoptosis, and expression of inflammatory cytokines IL-6 and IL-8. Palmitates 128-137 stearoyl-CoA desaturase Homo sapiens 51-57 18523127-7 2008 Increased hSCD-1 activity was determined as increased C16:1/16:0 ratio and enhanced triglyceride storage in palmitate treated cells. Palmitates 108-117 stearoyl-CoA desaturase Homo sapiens 10-16 18523127-9 2008 Overexpression of hSCD-1 blocked palmitate-induced cytotoxicity, and knockdown of hSCD-1 using siRNA abolished the protective effect of TO-901317 in HEK-293 cells. Palmitates 33-42 stearoyl-CoA desaturase Homo sapiens 18-24 18523127-10 2008 Additionally, inhibition of hSCD-1 with 10/12 CLA blocked the effect of TO-901317 on palmitate-induced lipotoxicity, cell apoptosis, and inflammatory cytokine induction in HAECs. Palmitates 85-94 stearoyl-CoA desaturase Homo sapiens 28-34 14967823-8 2004 The SCD inhibitors conjugated linoleic acid and troglitazone nearly abolished ABCA1 destabilization by palmitate and stearate but not by linoleate. Palmitates 103-112 stearoyl-CoA desaturase Homo sapiens 4-7 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Palmitates 111-120 stearoyl-CoA desaturase Homo sapiens 0-32 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Palmitates 111-120 stearoyl-CoA desaturase Homo sapiens 34-38 31796987-11 2020 Upon SCD knockdown, palmitate induced expression of dedifferentiation markers such as SOX9, MYC and HES1. Palmitates 20-29 stearoyl-CoA desaturase Homo sapiens 5-8 32245619-6 2020 We found that HN-treatment ameliorated palmitate-induced lipid accumulation, expression of lipogenesis-associated genes (processed SREBP1, FAS, and SCD1), cell death, and caspase 3 activity in hepatocytes in a dose-dependent manner. Palmitates 39-48 stearoyl-CoA desaturase Homo sapiens 148-152 33010452-7 2021 The stearoyl-CoA desaturase 1 (SCD1) index 1 (palmitoleate/palmitate) and index 2 (oleate/stearate) were reduced in T1DM (p<0.0001 for all). Palmitates 59-68 stearoyl-CoA desaturase Homo sapiens 31-35 31557308-3 2020 A SCD1-related oxidoreductase protects cells against palmitate toxicity, so we aimed to test whether desaturase activity is limited by SCD1 itself or by the associated electron supply. Palmitates 53-62 stearoyl-CoA desaturase Homo sapiens 2-6 31708874-6 2019 Therefore, in the present study, we have investigated the potential protective role of the enzyme stearoyl-CoA 9-desaturase 1 (SCD1) against the deleterious effects of Palm. Palmitates 168-172 stearoyl-CoA desaturase Homo sapiens 98-125 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Palmitates 204-213 stearoyl-CoA desaturase Homo sapiens 17-42 31936134-1 2020 In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS),(i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. Palmitates 204-213 stearoyl-CoA desaturase Homo sapiens 44-48 31708874-6 2019 Therefore, in the present study, we have investigated the potential protective role of the enzyme stearoyl-CoA 9-desaturase 1 (SCD1) against the deleterious effects of Palm. Palmitates 168-172 stearoyl-CoA desaturase Homo sapiens 127-131