PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30863363-10 2019 Both palmitate and brefeldin induced PERK, CHOP and BiP gene expression, which was partially, but significantly prevented by rapamycin. Palmitates 5-14 DNA damage inducible transcript 3 Homo sapiens 43-47 32639626-10 2020 Palmitate-induced ER stress led to PPARgamma expression through interactions between CHOP and FoxO6 corresponding to findings in vivo study. Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 85-89 31730796-6 2020 Furthermore, palmitate induced mRNA levels of endoplasmic reticulum (ER) stress markers, including Chop, Grp78 and Bax/Bcl2, as well as C/ebp-beta, whereas SNP induced Bax/Bcl2 and C/ebp-beta. Palmitates 13-22 DNA damage inducible transcript 3 Homo sapiens 99-103 31520549-5 2020 Palmitate led to cytotoxicity, TG accumulation, and apoptosis in HepG2 cells and also strongly induced ER stress indicated by increased GRP78, phosphorylation of eIF2alpha, ATF6, and CHOP. Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 183-187 28545881-9 2017 Treatment of human chondrocytes with palmitate induced expression of CHOP, activated JNK and inhibited IGF-1 function. Palmitates 37-46 DNA damage inducible transcript 3 Homo sapiens 69-73 30026676-7 2018 Results: BME significantly decreased expression levels of ER-stress markers (including phospho-eIF2alpha, CHOP, and phospho-JNK [Jun N-terminal kinases]) in PA-treated HepG2 cells. Palmitates 157-159 DNA damage inducible transcript 3 Homo sapiens 106-110 30674641-3 2019 In the present study, we found that palmitate treatment of human primary articular chondrocytes increased the expression of ER stress markers [activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP)] and apoptosis markers [cytochrome c and cleaved caspase-3 (CC3)]. Palmitates 36-45 DNA damage inducible transcript 3 Homo sapiens 185-209 30674641-3 2019 In the present study, we found that palmitate treatment of human primary articular chondrocytes increased the expression of ER stress markers [activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP)] and apoptosis markers [cytochrome c and cleaved caspase-3 (CC3)]. Palmitates 36-45 DNA damage inducible transcript 3 Homo sapiens 211-215 30307162-5 2018 After 2-day exposure to palmitate, OCR and the marker of the adaptive arm of ER stress response (sorcin) were significantly raised, whereas AMPK phosphorylation, markers of pro-apoptotic arm of ER stress response (p-EIF2alpha and CHOP) and apoptosis (cleaved caspase 3) were not affected. Palmitates 24-33 DNA damage inducible transcript 3 Homo sapiens 230-234 30307162-7 2018 After 7-day exposure to palmitate, OCR and sorcin were not significantly different from control level, p-AMPK was reduced and p-EIF2alpha, CHOP and cleaved caspase 3 were strongly upregulated. Palmitates 24-33 DNA damage inducible transcript 3 Homo sapiens 139-143 30307162-8 2018 Presence of metformin during 7-day culture with palmitate normalized the level of p-AMPK, p-EIF2alpha, CHOP and cleaved caspase 3 but significantly increased the level of sorcin. Palmitates 48-57 DNA damage inducible transcript 3 Homo sapiens 103-107 28931802-9 2017 Although basal expression of CHOP mRNA was enhanced in OR6 cells compared to cured cells, it was similarly upregulated in both cell lines following palmitate treatment. Palmitates 148-157 DNA damage inducible transcript 3 Homo sapiens 29-33 28397039-8 2017 Moreover, silencing CHOP by shRNA enhanced the release of EDA+ FN from hepatocytes following palmitate treatment, which was involved in ER stress-related cell damage. Palmitates 93-102 DNA damage inducible transcript 3 Homo sapiens 20-24 27555288-13 2016 Our study implicates for the first time ER stress-induced CHOP activation in the brain as a mechanistic link in the palmitate-induced negative regulation of leptin and IGF1, two neurotrophic cytokines that play an indispensable role in the mammalian brain. Palmitates 116-125 DNA damage inducible transcript 3 Homo sapiens 58-62 28159805-5 2017 We further found that palmitate, but not oleate or oleate with palmitate, increases endoplasmic reticulum (ER) stress, signaling through the unfolded protein response, and yielding CHOP-mediated induction of apoptosis. Palmitates 22-31 DNA damage inducible transcript 3 Homo sapiens 181-185 28159805-7 2017 The data show palmitate is toxic to human syncytiotrophoblasts, through the induction of ER stress and apoptosis mediated by CHOP, whereas oleate is not toxic, abrogates palmitate toxicity and induces fat accumulation. Palmitates 14-23 DNA damage inducible transcript 3 Homo sapiens 125-129 28304295-0 2017 Palmitate Increases beta-site AbetaPP-Cleavage Enzyme 1 Activity and Amyloid-beta Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation. Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 145-169 28304295-8 2017 We further show that CHOP is an indispensable molecular mediator of palmitate-induced upregulation in BACE1 activity and Abeta genesis. Palmitates 68-77 DNA damage inducible transcript 3 Homo sapiens 21-25 27464732-13 2016 In the lipogenic HER2/neu-positive SKBR3 cell line, palmitate induces a G2 phase cell cycle delay and CHOP-dependent apoptosis as well as a partial activation of the ER stress response network via XBP1 and ATF6. Palmitates 52-61 DNA damage inducible transcript 3 Homo sapiens 102-106 25653476-6 2015 Rapamycin attenuated PA-induced PERK and IRE1-associated UPR pathways, evidenced by decreased protein levels of eIF2alpha phosphorylation, ATF4, CHOP, and JNK phosphorylation. Palmitates 21-23 DNA damage inducible transcript 3 Homo sapiens 145-149 26419929-6 2015 Furthermore, CTRP9 decreased palmitate- or tunicamycin-induced ER stress markers, such as eIF2alpha, CHOP and IRE-1, in HepG2 cells. Palmitates 29-38 DNA damage inducible transcript 3 Homo sapiens 101-105 25647410-5 2015 Using TEM and western blot analysis, we observed increased ER stress in response to PA, as indicated by the increased levels of the ER stress markers, BiP, activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP), and the phosphoralytion of eukaryotic translation initiation factor 2alpha and c-Jun N-terminal kinase (JNK). Palmitates 84-86 DNA damage inducible transcript 3 Homo sapiens 201-225 25647410-5 2015 Using TEM and western blot analysis, we observed increased ER stress in response to PA, as indicated by the increased levels of the ER stress markers, BiP, activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP), and the phosphoralytion of eukaryotic translation initiation factor 2alpha and c-Jun N-terminal kinase (JNK). Palmitates 84-86 DNA damage inducible transcript 3 Homo sapiens 227-231 25314137-2 2014 Palmitate loading of cells activates the endoplasmic reticulum stress response, including induction of the proapoptotic transcription factor C/EBP homologous protein (CHOP). Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 141-165 25251292-2 2014 Compared to oleate, palmitate treatment resulted in less intracellular accumulation of lipid droplets and more ER stress, as measured by upregulation of CHOP, ATF6 and GRP78 gene expression and phosphorylation of eukaryotic initiation factor 2a (EIF2a). Palmitates 20-29 DNA damage inducible transcript 3 Homo sapiens 153-157 25314137-2 2014 Palmitate loading of cells activates the endoplasmic reticulum stress response, including induction of the proapoptotic transcription factor C/EBP homologous protein (CHOP). Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 167-171 25314137-10 2014 Our results suggest that palmitate-induced apoptosis requires maximal expression of CHOP which is achieved via the downregulation of its repressive microRNA, miR-615-3p. Palmitates 25-34 DNA damage inducible transcript 3 Homo sapiens 84-88 25610877-2 2014 The diabetogenic effect of palmitate is achieved by increasing beta cell death through induction of the endoplasmic reticulum (ER) stress markers including activating transcription factor 3 (Atf3) and CAAT/enhancer-binding protein homologous protein-10 (Chop). Palmitates 27-36 DNA damage inducible transcript 3 Homo sapiens 201-252 25610877-2 2014 The diabetogenic effect of palmitate is achieved by increasing beta cell death through induction of the endoplasmic reticulum (ER) stress markers including activating transcription factor 3 (Atf3) and CAAT/enhancer-binding protein homologous protein-10 (Chop). Palmitates 27-36 DNA damage inducible transcript 3 Homo sapiens 254-258 18544642-8 2008 In vitro, palmitate, thapsigargin, and tunicamycin but not oleate induced endoplasmic reticulum stress in HepG2 cells, including increased transcripts CHOP, ERN1, GADD34, and PERK, and increased XBP1 splicing along with phosphorylation of eukaryotic initiation factor eIF2alpha, JNK1, and c-jun. Palmitates 10-19 DNA damage inducible transcript 3 Homo sapiens 151-155 20970436-6 2010 KEY FINDINGS: Pa led to cytotoxicity and apoptosis in HepG2 cells in a dose-dependent pattern and also induced ER stress indicated by increased phosphorylation of eIF2alpha, upregulation of IRE1alpha and CHOP. Palmitates 14-16 DNA damage inducible transcript 3 Homo sapiens 204-208 20430872-5 2010 Our results demonstrate that short-hairpin RNA-targeted knockdown of CHOP attenuates palmitate-induced apoptosis in Huh-7 cells. Palmitates 85-94 DNA damage inducible transcript 3 Homo sapiens 69-73 18559892-9 2008 Blocking the transcription factor CHOP delayed palmitate-induced beta-cell apoptosis. Palmitates 47-56 DNA damage inducible transcript 3 Homo sapiens 34-38 32038787-6 2008 Palmitate led to increased expressions of the spliced form of X-box-protein (Xbp)-1 mRNA and C/EBP homologous transcription factor (CHOP) protein, suggesting activation of the unfolded-protein response. Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 93-130 32038787-6 2008 Palmitate led to increased expressions of the spliced form of X-box-protein (Xbp)-1 mRNA and C/EBP homologous transcription factor (CHOP) protein, suggesting activation of the unfolded-protein response. Palmitates 0-9 DNA damage inducible transcript 3 Homo sapiens 132-136