PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31591383-8 2019 In vitro treatment of primary macrophages and Raw 264.7 cells with conditioned media from hepatocytes pre-treated with PGRN prior to stimulation with tumor necrosis factor (TNF)-alpha or palmitate decreased their expression of pro-inflammatory genes. Palmitates 187-196 granulin Mus musculus 119-123 26039714-6 2015 Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2alpha axis of the ER stress response in action of PGRN. Palmitates 74-83 granulin Mus musculus 8-12