PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27653210-5 2016 The results showed that in homogenate-mitochondrial method, the protein level and activity of CYP2E1 were increased by ethanol and pyrazole; reduced by diallyldisulfide and kaempferol, and this homogenate-mitochondrial method is convenient with good repeatability and reproducibility in screening chemicals targeting CYP2E1, especially for the inducers. pyrazole 131-139 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 94-100 27653210-5 2016 The results showed that in homogenate-mitochondrial method, the protein level and activity of CYP2E1 were increased by ethanol and pyrazole; reduced by diallyldisulfide and kaempferol, and this homogenate-mitochondrial method is convenient with good repeatability and reproducibility in screening chemicals targeting CYP2E1, especially for the inducers. pyrazole 131-139 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 317-323 23400918-10 2013 Increases in Nrf2 protein and mRNA were observed in livers of chronic alcohol-fed mice or rats and of pyrazole-treated rats or mice, conditions known to elevate CYP2E1. pyrazole 102-110 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 161-167 22490042-3 2012 Pyrazole also induced the expression of CYP2E1, a primary reactive oxygen species (ROS) source for ethanol-induced liver injury, in ER and mitochondria. pyrazole 0-8 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 40-46 22490042-6 2012 In addition, pyrazole up-regulated CYP2E1 to a greater extent in mitochondria than in ER. pyrazole 13-21 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 35-41 22490042-11 2012 CONCLUSION: The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. pyrazole 87-95 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 162-168 21748763-0 2011 Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice. pyrazole 27-35 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 37-56 21748763-2 2011 Increased oxidative stress from CYP2E1 induction by pyrazole in vivo sensitizes the liver to TNF-alpha-induced hepatotoxicity by a mechanism involving the activation of c-jun N-terminal kinase (JNK) and mitochondrial damage. pyrazole 52-60 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 32-38 21748763-6 2011 Pyrazole elevated the activity and protein level of CYP2E1 in all mice. pyrazole 0-8 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 52-58 19671018-18 2009 However, it is not clear whether Nrf2 is protective against CYP2E1 toxicity in vivo as pyrazole which elevates CYP2E1 in wild-type mice did not elevate CYP2E1 in Nrf2 knockout mice, although pyrazole produced toxicity in the Nrf2 knockout mice. pyrazole 87-95 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 111-117 19671018-18 2009 However, it is not clear whether Nrf2 is protective against CYP2E1 toxicity in vivo as pyrazole which elevates CYP2E1 in wild-type mice did not elevate CYP2E1 in Nrf2 knockout mice, although pyrazole produced toxicity in the Nrf2 knockout mice. pyrazole 87-95 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 111-117 19477265-1 2009 We have previously shown that treatment of mice with pyrazole or acute ethanol potentiated Fas agonistic Jo2 antibody-induced liver injury by a mechanism involving induction of CYP2E1 and elevated oxidative stress. pyrazole 53-61 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 177-183 19063961-1 2009 Induction of CYP2E1 by pyrazole (PY) potentiated the hepatotoxicity induced by TNFalpha in mice. pyrazole 23-31 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 13-19 19063961-1 2009 Induction of CYP2E1 by pyrazole (PY) potentiated the hepatotoxicity induced by TNFalpha in mice. pyrazole 33-35 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 13-19 18721845-1 2008 Pyrazole can induce CYP2E1 and 2A5, which produce reactive oxygen species (ROS). pyrazole 0-8 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 20-34 18721845-5 2008 Activities and levels of CYP2E1 and 2A5 were elevated by pyrazole in the wild type mice but not in the Nrf2 knockout mice. pyrazole 57-65 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 25-39 17446309-1 2007 Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice. pyrazole 0-8 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 29-49 17446309-1 2007 Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice. pyrazole 0-8 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 51-57 17538970-3 2007 The aim of the present study was to evaluate whether acetone- or pyrazole-mediated induction of CYP2E1 can potentiate liver injury in obesity. pyrazole 65-73 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 96-102 17538970-4 2007 CYP2E1 protein and activity were elevated in acetone- or pyrazole-treated obese and lean mice. pyrazole 57-65 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 16958665-10 2006 Increases in nuclear factor erythroid 2-related factor 2 (Nrf2) protein and mRNA were observed in livers of hepatocytes of chronic alcohol-fed and of pyrazole-treated rats or mice, conditions known to elevate CYP2E1. pyrazole 150-158 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 209-215 16799984-3 2006 In the present study, the possible synergistic action of CYP2E1 and LPS in liver injury was investigated by evaluating the effects of pyrazole (inducer of CYP2E1), Chlormethiazole (CMZ), an inhibitor of CYP2E1, and CYP2E1-knockout mice. pyrazole 134-142 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 57-63 16799984-3 2006 In the present study, the possible synergistic action of CYP2E1 and LPS in liver injury was investigated by evaluating the effects of pyrazole (inducer of CYP2E1), Chlormethiazole (CMZ), an inhibitor of CYP2E1, and CYP2E1-knockout mice. pyrazole 134-142 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 155-161 16799984-3 2006 In the present study, the possible synergistic action of CYP2E1 and LPS in liver injury was investigated by evaluating the effects of pyrazole (inducer of CYP2E1), Chlormethiazole (CMZ), an inhibitor of CYP2E1, and CYP2E1-knockout mice. pyrazole 134-142 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 155-161 16799984-3 2006 In the present study, the possible synergistic action of CYP2E1 and LPS in liver injury was investigated by evaluating the effects of pyrazole (inducer of CYP2E1), Chlormethiazole (CMZ), an inhibitor of CYP2E1, and CYP2E1-knockout mice. pyrazole 134-142 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 155-161 16799984-9 2006 CYP2E1 but also CYP2A5 were increased by the pyrazole/LPS treatment. pyrazole 45-53 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 16799984-11 2006 CYP2E1-knockout mice exhibited only minor liver injury after treatment with pyrazole/LPS, but wild-type mice exhibited severe liver injury. pyrazole 76-84 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 16799984-13 2006 In conclusion, induction of CYP2E1 plays an important role in the enhancement of LPS liver injury by pyrazole, but some contribution by CYP2A5 cannot be excluded. pyrazole 101-109 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 28-34 16373529-3 2006 We recently reported that treatment of mice with pyrazole to induce CYP2E1 increased hepatotoxicity produced by Fas agonistic Jo2 antibody. pyrazole 49-57 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 68-74 16374848-4 2006 Increases in Nrf2 protein and mRNA were observed in livers or hepatocytes of chronic alcohol-fed mice or rats and of pyrazole-treated rats or mice, conditions known to elevate CYP2E1. pyrazole 117-125 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 176-182 16025513-3 2005 C57BL/6 mice were injected intraperitoneally with pyrazole (Pyr) to induce CYP2E1. pyrazole 50-58 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 75-81 16025513-3 2005 C57BL/6 mice were injected intraperitoneally with pyrazole (Pyr) to induce CYP2E1. pyrazole 60-63 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 75-81 11803702-57 1999 Induction of cytochrome P(450)2E1 by pyrazole increased the concentrations of lipid peroxidation products; inhibition of cytochrome P(450)2E1 by 2,4-dinitrophenylhydrazine reduced these concentrations. pyrazole 37-45 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 13-33 9698299-5 1998 On the other hand, pyrazole treatment induced CYP2E1 in the olfactory mucosa as well as in liver and kidney, indicating that the olfactory mucosa was exposed to pyrazole. pyrazole 19-27 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 46-52 9698299-5 1998 On the other hand, pyrazole treatment induced CYP2E1 in the olfactory mucosa as well as in liver and kidney, indicating that the olfactory mucosa was exposed to pyrazole. pyrazole 161-169 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 46-52