PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28171821-3 2017 In this study, the effects of ER stress inducer thapsigargin (TG) on the toxicity of ZnO NPs to THP-1 macrophages were investigated. Zinc Oxide 85-88 GLI family zinc finger 2 Homo sapiens 96-101 28710015-10 2017 Based on previous research, ZnO NPs had strong anti-tubercular impact against H37RvMTB to in-vitro condition, but it was toxic in concentration of ~ 0.468 ppm to both of THP-1 and normal lung (MRC-5) cell lines. Zinc Oxide 28-31 GLI family zinc finger 2 Homo sapiens 170-175 28171821-6 2017 In the co-culture, exposure of THP-1 macrophages in the upper chamber to ZnO NPs and TG significantly reduced the viability of human umbilical vein endothelial cells (HUVECs) in the lower chamber, but the release of tumor necrosis factor alpha (TNFalpha) was not induced. Zinc Oxide 73-76 GLI family zinc finger 2 Homo sapiens 31-36 28171821-7 2017 In summary, our data showed that stressing THP-1 macrophages with TG enhanced the cytotoxicity of ZnO NPs to macrophages and macrophage-endothelial co-cultures. Zinc Oxide 98-101 GLI family zinc finger 2 Homo sapiens 43-48 27770658-0 2016 Combined effects of low levels of palmitate on toxicity of ZnO nanoparticles to THP-1 macrophages. Zinc Oxide 59-62 GLI family zinc finger 2 Homo sapiens 80-85 27770658-6 2016 In addition, ZnO NPs dose-dependently increased intracellular Zn ions in THP-1 macrophages, which was not significantly affected by PA. Zinc Oxide 13-16 GLI family zinc finger 2 Homo sapiens 73-78 27770658-7 2016 Taken together, the results of the present study showed a combined toxicity of low levels of PA and ZnO NPs especially to lysosomes in THP-1 macrophages. Zinc Oxide 100-103 GLI family zinc finger 2 Homo sapiens 135-140 32319286-2 2020 The present study was designed to determine the effects of silica dioxide (SiO2), titanium dioxide (TiO2), and zinc oxide (ZnO) NPs on cultured THP-1 monocyte-derived macrophages and human epithelial colorectal adenocarcinoma (Caco-2) cells. Zinc Oxide 111-121 GLI family zinc finger 2 Homo sapiens 144-149 24746987-5 2014 The 16-hour exposure to ZnO particles increased the level of monocyte chemotactic protein-1 (MCP-1) and induced the migration of THP-1 monocyte mediated by increased MCP-1. Zinc Oxide 24-27 GLI family zinc finger 2 Homo sapiens 129-134 24746987-6 2014 Exposure to ZnO particles also induced adhesion of THP-1 cells to HUVECs. Zinc Oxide 12-15 GLI family zinc finger 2 Homo sapiens 51-56 24746987-7 2014 Moreover, exposure to ZnO particles, but not TiO2 particles, upregulated the expression of membrane scavenger receptors of modified LDL and increased cholesterol uptake in THP-1 monocytes/macrophages. Zinc Oxide 22-25 GLI family zinc finger 2 Homo sapiens 172-177 24187959-3 2013 In this study, rapid scanning X-ray fluorescence microscopy was used to assay the number ZnO nanoparticles associated with ~1000 individual THP-1 monocyte-derived human macrophages. Zinc Oxide 89-92 GLI family zinc finger 2 Homo sapiens 140-145 23142470-1 2013 Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. Zinc Oxide 0-10 GLI family zinc finger 2 Homo sapiens 197-201 23142470-1 2013 Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. Zinc Oxide 12-15 GLI family zinc finger 2 Homo sapiens 197-201 23142470-5 2013 This association with protein may influence interaction of the ZnO particles and NP with THP1 cells. Zinc Oxide 63-66 GLI family zinc finger 2 Homo sapiens 89-93 26146191-4 2015 Therefore, the present study was aimed to investigate the immunotoxic potential of ZnO NPs using human monocytic cell line (THP-1) as model to understand the underlying molecular mechanism. Zinc Oxide 83-86 GLI family zinc finger 2 Homo sapiens 124-129 32319286-2 2020 The present study was designed to determine the effects of silica dioxide (SiO2), titanium dioxide (TiO2), and zinc oxide (ZnO) NPs on cultured THP-1 monocyte-derived macrophages and human epithelial colorectal adenocarcinoma (Caco-2) cells. Zinc Oxide 123-126 GLI family zinc finger 2 Homo sapiens 144-149 32319286-3 2020 Exposure to ZnO NPs for 24 hours increased the production of redox response species (ROS) and reduced cell viability in a dose-dependent manner in THP-1 macrophages and Caco-2 cells. Zinc Oxide 12-15 GLI family zinc finger 2 Homo sapiens 147-152 30423365-0 2019 Cytotoxicity and global transcriptional responses induced by zinc oxide nanoparticles NM 110 in PMA-differentiated THP-1 cells. Zinc Oxide 61-71 GLI family zinc finger 2 Homo sapiens 115-120 30423365-2 2019 Thus, we have used, as a model, zinc oxide nanoparticle NM110 (ZnO110NP) exposure to PMA-differentiated THP-1 macrophages. Zinc Oxide 32-42 GLI family zinc finger 2 Homo sapiens 104-109 30620997-3 2019 In this study, we investigated the combined toxicity of ZnO NRs/Mini-NRs and palmitate (PA) to THP-1 macrophages. Zinc Oxide 56-59 GLI family zinc finger 2 Homo sapiens 95-100 29691881-4 2018 Surprisingly, H3 markedly decreased the initial concentration of ZnO NPs required to induce cytotoxicity to Caco-2, HepG2, THP-1 and human umbilical vein endothelial cells, which suggested that H3 could promote the toxicity of ZnO NPs to both cancerous and normal cells. Zinc Oxide 65-68 GLI family zinc finger 2 Homo sapiens 123-128 30461332-0 2019 Toxicity of ZnO nanoparticles (NPs) to THP-1 macrophages: interactions with saturated or unsaturated free fatty acids. Zinc Oxide 12-15 GLI family zinc finger 2 Homo sapiens 39-44 29783874-0 2018 Influence of bovine serum albumin pre-incubation on toxicity and ER stress-apoptosis gene expression in THP-1 macrophages exposed to ZnO nanoparticles. Zinc Oxide 133-136 GLI family zinc finger 2 Homo sapiens 104-109 29783874-7 2018 However, ZnO NPs with or without pre-incubation of BSA resulted in comparable intracellular Zn ions, glutathione and reactive oxygen species in THP-1 macrophages. Zinc Oxide 9-12 GLI family zinc finger 2 Homo sapiens 144-149 29697006-0 2018 Toxicity of ZnO nanoparticles (NPs) with or without hydrophobic surface coating to THP-1 macrophages: interactions with BSA or oleate-BSA. Zinc Oxide 12-15 GLI family zinc finger 2 Homo sapiens 83-88 29697006-6 2018 Exposure to both types of ZnO NPs was associated with cytotoxicity to THP-1 macrophages, which was equally mitigated by BSA or OA-BSA associated with decreased cellular Zn elements. Zinc Oxide 26-29 GLI family zinc finger 2 Homo sapiens 70-75